Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   P8R99_RS06490 Genome accession   NZ_CP121160
Coordinates   1238721..1239200 (-) Length   159 a.a.
NCBI ID   WP_001204194.1    Uniprot ID   A0AAV3JNR5
Organism   Streptococcus agalactiae strain S5     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1196652..1238542 1238721..1239200 flank 179


Gene organization within MGE regions


Location: 1196652..1239200
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8R99_RS06180 - 1196652..1197227 (-) 576 WP_001231504.1 glucosaminidase domain-containing protein -
  P8R99_RS06185 - 1197224..1197976 (-) 753 WP_000739808.1 M15 family metallopeptidase -
  P8R99_RS06190 - 1197973..1198665 (-) 693 WP_000049274.1 histidine phosphatase family protein -
  P8R99_RS06195 prx 1198878..1199060 (-) 183 WP_222335082.1 Paratox Regulator
  P8R99_RS06200 - 1199172..1199372 (-) 201 WP_000076712.1 CsbD family protein -
  P8R99_RS06205 - 1199482..1199781 (-) 300 WP_000258211.1 STAS-like domain-containing protein -
  P8R99_RS06210 - 1199775..1200671 (-) 897 WP_001061853.1 sensor histidine kinase -
  P8R99_RS06215 - 1200807..1202137 (-) 1331 Protein_1200 GH25 family lysozyme -
  P8R99_RS06220 - 1202267..1202518 (-) 252 WP_222334957.1 phage holin -
  P8R99_RS06225 - 1202520..1202807 (-) 288 WP_025196063.1 hypothetical protein -
  P8R99_RS06230 - 1202826..1202984 (-) 159 WP_223297809.1 hypothetical protein -
  P8R99_RS06235 - 1203013..1203339 (-) 327 WP_222335085.1 DUF1366 domain-containing protein -
  P8R99_RS06240 - 1203353..1205344 (-) 1992 WP_065733340.1 DUF859 family phage minor structural protein -
  P8R99_RS06245 - 1205357..1209175 (-) 3819 WP_278043251.1 glucosaminidase domain-containing protein -
  P8R99_RS06250 - 1209166..1210686 (-) 1521 WP_222335090.1 distal tail protein Dit -
  P8R99_RS06255 - 1210697..1212895 (-) 2199 WP_053515049.1 hypothetical protein -
  P8R99_RS06260 - 1212888..1213346 (-) 459 WP_053515048.1 hypothetical protein -
  P8R99_RS06265 - 1213319..1213636 (-) 318 WP_053515047.1 hypothetical protein -
  P8R99_RS06270 - 1213649..1214155 (-) 507 WP_053515046.1 phage major tail protein, TP901-1 family -
  P8R99_RS06275 - 1214167..1214577 (-) 411 WP_278043252.1 DUF5072 family protein -
  P8R99_RS06280 - 1214579..1214974 (-) 396 WP_053515044.1 hypothetical protein -
  P8R99_RS06285 - 1214971..1215282 (-) 312 WP_053515043.1 hypothetical protein -
  P8R99_RS06290 - 1215279..1215623 (-) 345 WP_053515042.1 hypothetical protein -
  P8R99_RS06295 - 1215637..1215930 (-) 294 WP_222334961.1 HeH/LEM domain-containing protein -
  P8R99_RS06300 - 1215943..1216833 (-) 891 WP_053515040.1 hypothetical protein -
  P8R99_RS06305 - 1216852..1217421 (-) 570 WP_053515039.1 DUF4355 domain-containing protein -
  P8R99_RS06310 - 1217535..1217861 (-) 327 WP_053515038.1 hypothetical protein -
  P8R99_RS06315 - 1217995..1218921 (-) 927 WP_061811549.1 minor capsid protein -
  P8R99_RS06320 - 1218890..1220215 (-) 1326 WP_065367292.1 phage portal protein -
  P8R99_RS06325 - 1220215..1221489 (-) 1275 WP_000634503.1 PBSX family phage terminase large subunit -
  P8R99_RS06330 - 1221479..1221859 (-) 381 WP_000090087.1 hypothetical protein -
  P8R99_RS06340 - 1223195..1223632 (-) 438 WP_017648353.1 DUF1492 domain-containing protein -
  P8R99_RS06345 - 1224092..1224310 (-) 219 WP_202618508.1 hypothetical protein -
  P8R99_RS06350 - 1224328..1224645 (-) 318 WP_053515035.1 hypothetical protein -
  P8R99_RS06355 - 1224632..1225162 (-) 531 WP_129316756.1 DUF1642 domain-containing protein -
  P8R99_RS06360 - 1225364..1225558 (-) 195 WP_223875820.1 hypothetical protein -
  P8R99_RS06365 - 1225619..1225831 (-) 213 WP_003047486.1 hypothetical protein -
  P8R99_RS06370 - 1225828..1226232 (-) 405 WP_222335087.1 YopX family protein -
  P8R99_RS06375 - 1226229..1226387 (-) 159 WP_017647865.1 hypothetical protein -
  P8R99_RS06380 - 1226371..1226667 (-) 297 WP_222334966.1 nucleotide modification associated domain-containing protein -
  P8R99_RS06385 - 1226664..1226912 (-) 249 WP_222334967.1 hypothetical protein -
  P8R99_RS06390 - 1226909..1227265 (-) 357 WP_222334968.1 hypothetical protein -
  P8R99_RS06395 - 1227249..1227536 (-) 288 WP_230243757.1 VRR-NUC domain-containing protein -
  P8R99_RS06400 - 1227556..1228428 (-) 873 WP_222335088.1 bifunctional DNA primase/polymerase -
  P8R99_RS06405 - 1228697..1230250 (-) 1554 WP_222335089.1 phage resistance protein -
  P8R99_RS06410 - 1230267..1230749 (-) 483 WP_222334972.1 DUF669 domain-containing protein -
  P8R99_RS06415 - 1230754..1232136 (-) 1383 WP_230249748.1 DEAD/DEAH box helicase family protein -
  P8R99_RS06420 - 1232193..1232876 (-) 684 WP_000704951.1 AAA family ATPase -
  P8R99_RS06425 - 1232863..1233153 (-) 291 WP_000650504.1 hypothetical protein -
  P8R99_RS06430 - 1233150..1233350 (-) 201 WP_001058282.1 hypothetical protein -
  P8R99_RS06435 - 1233426..1233569 (-) 144 WP_017647875.1 hypothetical protein -
  P8R99_RS06440 - 1233599..1233856 (-) 258 WP_001191791.1 hypothetical protein -
  P8R99_RS06445 - 1233934..1234119 (-) 186 WP_017285241.1 helix-turn-helix transcriptional regulator -
  P8R99_RS06450 - 1234263..1234439 (+) 177 WP_164971201.1 hypothetical protein -
  P8R99_RS06455 - 1234467..1234655 (-) 189 WP_000724352.1 hypothetical protein -
  P8R99_RS06460 - 1234688..1235416 (-) 729 WP_017647877.1 phage antirepressor KilAC domain-containing protein -
  P8R99_RS06465 - 1235464..1235664 (-) 201 WP_001875236.1 helix-turn-helix transcriptional regulator -
  P8R99_RS06470 - 1235853..1236215 (+) 363 WP_061811548.1 helix-turn-helix transcriptional regulator -
  P8R99_RS06475 - 1236199..1236576 (+) 378 WP_053515022.1 ImmA/IrrE family metallo-endopeptidase -
  P8R99_RS06480 - 1236585..1237271 (+) 687 WP_053515021.1 hypothetical protein -
  P8R99_RS06485 - 1237445..1238542 (+) 1098 WP_000570848.1 site-specific integrase -
  P8R99_RS06490 comX/sigX 1238721..1239200 (-) 480 WP_001204194.1 sigma-70 family RNA polymerase sigma factor Regulator

Sequence

Protein


Download         Length: 159 a.a.        Molecular weight: 19447.28 Da        Isoelectric Point: 6.2639

>NTDB_id=810673 P8R99_RS06490 WP_001204194.1 1238721..1239200(-) (comX/sigX) [Streptococcus agalactiae strain S5]
MRDFEELFDKVKPIVMKLRRNYFVQLWEYDDWIQEGRIVLFRLLEEHPYLLDNESKLFIYFKTKFSNYLNDVLRHQDCQK
RQFNKMPYEEISEVSHYVKSKGLVLDDYIAYRDTLTKVEETLSDIDKEKFEKLISGERFAGKKQFIRDIQPFFNAFKAD

Nucleotide


Download         Length: 480 bp        

>NTDB_id=810673 P8R99_RS06490 WP_001204194.1 1238721..1239200(-) (comX/sigX) [Streptococcus agalactiae strain S5]
TTGAGAGATTTTGAGGAGTTGTTTGATAAAGTAAAGCCAATCGTAATGAAGCTGAGAAGAAATTATTTTGTTCAACTTTG
GGAATATGATGATTGGATTCAAGAAGGACGTATTGTACTTTTTAGGTTGCTTGAAGAGCATCCGTATTTATTGGATAATG
AAAGCAAACTATTCATTTACTTTAAAACAAAATTTTCAAATTATTTAAACGATGTATTAAGACACCAAGATTGTCAAAAG
CGACAATTTAATAAAATGCCTTATGAAGAAATCAGTGAAGTTAGTCACTATGTTAAGAGTAAAGGACTAGTTTTAGATGA
CTATATTGCTTATCGTGATACTTTAACAAAAGTGGAAGAAACTTTGTCAGATATTGATAAAGAAAAATTTGAAAAACTGA
TTAGTGGTGAACGTTTTGCGGGGAAGAAACAATTCATACGAGATATTCAACCTTTTTTCAATGCTTTTAAAGCGGATTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

56.688

98.742

0.56
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

52.349

93.711

0.491
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

52.349

93.711

0.491
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

52

94.34

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

52

94.34

0.491
  comX/sigX Streptococcus mutans UA159

49.677

97.484

0.484
  comX Streptococcus sobrinus strain NIDR 6715-7

43.59

98.113

0.428
  comX/sigX Streptococcus suis D9

43.226

97.484

0.421
  comX/sigX Streptococcus suis isolate S10

43.226

97.484

0.421
  comX/sigX Streptococcus suis P1/7

43.226

97.484

0.421
  comX Streptococcus thermophilus LMD-9

42.177

92.453

0.39
  comX Streptococcus thermophilus LMG 18311

42.177

92.453

0.39
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

39.869

96.226

0.384
  comX/comX2 Streptococcus pneumoniae Rx1

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae Rx1

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae D39

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae D39

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae R6

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae R6

40.397

94.969

0.384
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

39.216

96.226

0.377
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

39.216

96.226

0.377
  comX Streptococcus salivarius SK126

40.816

92.453

0.377
  comX/sigX Streptococcus salivarius strain HSISS4

40.816

92.453

0.377
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

38.562

96.226

0.371