Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   P8R99_RS06195 Genome accession   NZ_CP121160
Coordinates   1198878..1199060 (-) Length   60 a.a.
NCBI ID   WP_222335082.1    Uniprot ID   -
Organism   Streptococcus agalactiae strain S5     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1196652..1238542 1198878..1199060 within 0


Gene organization within MGE regions


Location: 1196652..1238542
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8R99_RS06180 - 1196652..1197227 (-) 576 WP_001231504.1 glucosaminidase domain-containing protein -
  P8R99_RS06185 - 1197224..1197976 (-) 753 WP_000739808.1 M15 family metallopeptidase -
  P8R99_RS06190 - 1197973..1198665 (-) 693 WP_000049274.1 histidine phosphatase family protein -
  P8R99_RS06195 prx 1198878..1199060 (-) 183 WP_222335082.1 Paratox Regulator
  P8R99_RS06200 - 1199172..1199372 (-) 201 WP_000076712.1 CsbD family protein -
  P8R99_RS06205 - 1199482..1199781 (-) 300 WP_000258211.1 STAS-like domain-containing protein -
  P8R99_RS06210 - 1199775..1200671 (-) 897 WP_001061853.1 sensor histidine kinase -
  P8R99_RS06215 - 1200807..1202137 (-) 1331 Protein_1200 GH25 family lysozyme -
  P8R99_RS06220 - 1202267..1202518 (-) 252 WP_222334957.1 phage holin -
  P8R99_RS06225 - 1202520..1202807 (-) 288 WP_025196063.1 hypothetical protein -
  P8R99_RS06230 - 1202826..1202984 (-) 159 WP_223297809.1 hypothetical protein -
  P8R99_RS06235 - 1203013..1203339 (-) 327 WP_222335085.1 DUF1366 domain-containing protein -
  P8R99_RS06240 - 1203353..1205344 (-) 1992 WP_065733340.1 DUF859 family phage minor structural protein -
  P8R99_RS06245 - 1205357..1209175 (-) 3819 WP_278043251.1 glucosaminidase domain-containing protein -
  P8R99_RS06250 - 1209166..1210686 (-) 1521 WP_222335090.1 distal tail protein Dit -
  P8R99_RS06255 - 1210697..1212895 (-) 2199 WP_053515049.1 hypothetical protein -
  P8R99_RS06260 - 1212888..1213346 (-) 459 WP_053515048.1 hypothetical protein -
  P8R99_RS06265 - 1213319..1213636 (-) 318 WP_053515047.1 hypothetical protein -
  P8R99_RS06270 - 1213649..1214155 (-) 507 WP_053515046.1 phage major tail protein, TP901-1 family -
  P8R99_RS06275 - 1214167..1214577 (-) 411 WP_278043252.1 DUF5072 family protein -
  P8R99_RS06280 - 1214579..1214974 (-) 396 WP_053515044.1 hypothetical protein -
  P8R99_RS06285 - 1214971..1215282 (-) 312 WP_053515043.1 hypothetical protein -
  P8R99_RS06290 - 1215279..1215623 (-) 345 WP_053515042.1 hypothetical protein -
  P8R99_RS06295 - 1215637..1215930 (-) 294 WP_222334961.1 HeH/LEM domain-containing protein -
  P8R99_RS06300 - 1215943..1216833 (-) 891 WP_053515040.1 hypothetical protein -
  P8R99_RS06305 - 1216852..1217421 (-) 570 WP_053515039.1 DUF4355 domain-containing protein -
  P8R99_RS06310 - 1217535..1217861 (-) 327 WP_053515038.1 hypothetical protein -
  P8R99_RS06315 - 1217995..1218921 (-) 927 WP_061811549.1 minor capsid protein -
  P8R99_RS06320 - 1218890..1220215 (-) 1326 WP_065367292.1 phage portal protein -
  P8R99_RS06325 - 1220215..1221489 (-) 1275 WP_000634503.1 PBSX family phage terminase large subunit -
  P8R99_RS06330 - 1221479..1221859 (-) 381 WP_000090087.1 hypothetical protein -
  P8R99_RS06340 - 1223195..1223632 (-) 438 WP_017648353.1 DUF1492 domain-containing protein -
  P8R99_RS06345 - 1224092..1224310 (-) 219 WP_202618508.1 hypothetical protein -
  P8R99_RS06350 - 1224328..1224645 (-) 318 WP_053515035.1 hypothetical protein -
  P8R99_RS06355 - 1224632..1225162 (-) 531 WP_129316756.1 DUF1642 domain-containing protein -
  P8R99_RS06360 - 1225364..1225558 (-) 195 WP_223875820.1 hypothetical protein -
  P8R99_RS06365 - 1225619..1225831 (-) 213 WP_003047486.1 hypothetical protein -
  P8R99_RS06370 - 1225828..1226232 (-) 405 WP_222335087.1 YopX family protein -
  P8R99_RS06375 - 1226229..1226387 (-) 159 WP_017647865.1 hypothetical protein -
  P8R99_RS06380 - 1226371..1226667 (-) 297 WP_222334966.1 nucleotide modification associated domain-containing protein -
  P8R99_RS06385 - 1226664..1226912 (-) 249 WP_222334967.1 hypothetical protein -
  P8R99_RS06390 - 1226909..1227265 (-) 357 WP_222334968.1 hypothetical protein -
  P8R99_RS06395 - 1227249..1227536 (-) 288 WP_230243757.1 VRR-NUC domain-containing protein -
  P8R99_RS06400 - 1227556..1228428 (-) 873 WP_222335088.1 bifunctional DNA primase/polymerase -
  P8R99_RS06405 - 1228697..1230250 (-) 1554 WP_222335089.1 phage resistance protein -
  P8R99_RS06410 - 1230267..1230749 (-) 483 WP_222334972.1 DUF669 domain-containing protein -
  P8R99_RS06415 - 1230754..1232136 (-) 1383 WP_230249748.1 DEAD/DEAH box helicase family protein -
  P8R99_RS06420 - 1232193..1232876 (-) 684 WP_000704951.1 AAA family ATPase -
  P8R99_RS06425 - 1232863..1233153 (-) 291 WP_000650504.1 hypothetical protein -
  P8R99_RS06430 - 1233150..1233350 (-) 201 WP_001058282.1 hypothetical protein -
  P8R99_RS06435 - 1233426..1233569 (-) 144 WP_017647875.1 hypothetical protein -
  P8R99_RS06440 - 1233599..1233856 (-) 258 WP_001191791.1 hypothetical protein -
  P8R99_RS06445 - 1233934..1234119 (-) 186 WP_017285241.1 helix-turn-helix transcriptional regulator -
  P8R99_RS06450 - 1234263..1234439 (+) 177 WP_164971201.1 hypothetical protein -
  P8R99_RS06455 - 1234467..1234655 (-) 189 WP_000724352.1 hypothetical protein -
  P8R99_RS06460 - 1234688..1235416 (-) 729 WP_017647877.1 phage antirepressor KilAC domain-containing protein -
  P8R99_RS06465 - 1235464..1235664 (-) 201 WP_001875236.1 helix-turn-helix transcriptional regulator -
  P8R99_RS06470 - 1235853..1236215 (+) 363 WP_061811548.1 helix-turn-helix transcriptional regulator -
  P8R99_RS06475 - 1236199..1236576 (+) 378 WP_053515022.1 ImmA/IrrE family metallo-endopeptidase -
  P8R99_RS06480 - 1236585..1237271 (+) 687 WP_053515021.1 hypothetical protein -
  P8R99_RS06485 - 1237445..1238542 (+) 1098 WP_000570848.1 site-specific integrase -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6898.94 Da        Isoelectric Point: 4.1370

>NTDB_id=810672 P8R99_RS06195 WP_222335082.1 1198878..1199060(-) (prx) [Streptococcus agalactiae strain S5]
MLYIDELQEAIDKGYISGNTVAIVRKNGKIFDYVLPGEPVRLWEVATEEKVEEVLMELDK

Nucleotide


Download         Length: 183 bp        

>NTDB_id=810672 P8R99_RS06195 WP_222335082.1 1198878..1199060(-) (prx) [Streptococcus agalactiae strain S5]
ATGTTATATATAGATGAGCTACAAGAAGCGATTGATAAAGGCTATATTTCAGGGAACACAGTAGCGATAGTGCGTAAAAA
CGGAAAGATATTTGATTATGTGTTACCTGGTGAGCCTGTAAGATTGTGGGAAGTTGCGACAGAGGAAAAAGTGGAAGAAG
TGTTGATGGAATTAGATAAATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

70

100

0.7
  prx Streptococcus pyogenes MGAS8232

66.667

100

0.667
  prx Streptococcus pyogenes MGAS315

65

100

0.65
  prx Streptococcus pyogenes MGAS315

61.667

100

0.617
  prx Streptococcus pyogenes MGAS315

85.366

68.333

0.583
  prx Streptococcus pyogenes MGAS315

75.61

68.333

0.517
  prx Streptococcus pyogenes MGAS315

68.293

68.333

0.467