Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   EGX72_RS00430 Genome accession   NZ_CP033809
Coordinates   71598..72077 (-) Length   159 a.a.
NCBI ID   WP_001204194.1    Uniprot ID   A0AAV3JNR5
Organism   Streptococcus sp. FDAARGOS_521     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 25264..71419 71598..72077 flank 179


Gene organization within MGE regions


Location: 25264..72077
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EGX72_RS00130 (EGX72_00130) - 25264..25839 (-) 576 WP_001231504.1 glycoside hydrolase family 73 protein -
  EGX72_RS00135 (EGX72_00135) - 25836..26588 (-) 753 WP_000739660.1 M15 family metallopeptidase -
  EGX72_RS00140 (EGX72_00140) - 26585..27277 (-) 693 WP_000049272.1 histidine phosphatase family protein -
  EGX72_RS00145 (EGX72_00145) prx 27490..27672 (-) 183 WP_000965649.1 hypothetical protein Regulator
  EGX72_RS00150 (EGX72_00150) - 27901..28413 (-) 513 WP_000634505.1 PBECR4 domain-containing protein -
  EGX72_RS00155 (EGX72_00155) - 28779..30113 (-) 1335 WP_000257233.1 GH25 family lysozyme -
  EGX72_RS00160 (EGX72_00160) - 30239..30493 (-) 255 WP_000611524.1 phage holin -
  EGX72_RS00165 (EGX72_00165) - 30495..30797 (-) 303 WP_000215499.1 hypothetical protein -
  EGX72_RS00170 (EGX72_00170) - 30810..31022 (-) 213 WP_000698337.1 hypothetical protein -
  EGX72_RS00175 (EGX72_00175) - 30997..31326 (-) 330 WP_000494205.1 DUF1366 domain-containing protein -
  EGX72_RS00180 (EGX72_00180) - 31352..33357 (-) 2006 Protein_34 DUF859 family phage minor structural protein -
  EGX72_RS00185 (EGX72_00185) - 33368..37502 (-) 4135 Protein_35 glucosaminidase domain-containing protein -
  EGX72_RS00190 (EGX72_00190) - 37493..39016 (-) 1524 WP_060794297.1 distal tail protein Dit -
  EGX72_RS00195 (EGX72_00195) - 39013..42954 (-) 3942 WP_000526768.1 phage tail tape measure protein -
  EGX72_RS11535 - 42967..43140 (-) 174 WP_000928086.1 hypothetical protein -
  EGX72_RS00200 (EGX72_00200) - 43164..43484 (-) 321 WP_000273026.1 hypothetical protein -
  EGX72_RS00205 (EGX72_00205) - 43592..44149 (-) 558 WP_000521115.1 major tail protein -
  EGX72_RS00210 (EGX72_00210) - 44165..44590 (-) 426 WP_000559945.1 hypothetical protein -
  EGX72_RS00215 (EGX72_00215) - 44587..44964 (-) 378 WP_000160229.1 HK97-gp10 family putative phage morphogenesis protein -
  EGX72_RS00220 (EGX72_00220) - 44961..45308 (-) 348 WP_000632972.1 phage head closure protein -
  EGX72_RS00225 (EGX72_00225) - 45305..45607 (-) 303 WP_000301152.1 head-tail connector protein -
  EGX72_RS00230 (EGX72_00230) - 45743..46924 (-) 1182 WP_000461336.1 phage major capsid protein -
  EGX72_RS00235 (EGX72_00235) - 46949..47614 (-) 666 WP_001126088.1 head maturation protease, ClpP-related -
  EGX72_RS00240 (EGX72_00240) - 47592..48812 (-) 1221 WP_000007730.1 phage portal protein -
  EGX72_RS00245 (EGX72_00245) - 48842..49045 (-) 204 WP_001042282.1 hypothetical protein -
  EGX72_RS11540 - 49042..49209 (-) 168 WP_000578946.1 hypothetical protein -
  EGX72_RS00250 (EGX72_00250) - 49206..50960 (-) 1755 WP_025194528.1 terminase large subunit -
  EGX72_RS00255 (EGX72_00255) - 50964..51194 (-) 231 WP_000805624.1 hypothetical protein -
  EGX72_RS00260 (EGX72_00260) - 51197..51664 (-) 468 WP_000532792.1 phage terminase small subunit P27 family -
  EGX72_RS00265 (EGX72_00265) - 51828..52172 (-) 345 WP_001247767.1 HNH endonuclease -
  EGX72_RS00270 (EGX72_00270) - 52273..52458 (+) 186 WP_001132272.1 type II toxin-antitoxin system HicA family toxin -
  EGX72_RS00275 (EGX72_00275) - 52511..52888 (+) 378 WP_000964195.1 type II toxin-antitoxin system HicB family antitoxin -
  EGX72_RS00285 (EGX72_00285) - 54094..54528 (-) 435 WP_000142570.1 ArpU family phage packaging/lysis transcriptional regulator -
  EGX72_RS00290 (EGX72_00290) - 54920..55186 (-) 267 WP_000660740.1 hypothetical protein -
  EGX72_RS00295 (EGX72_00295) - 55183..55716 (-) 534 WP_060794278.1 DUF1642 domain-containing protein -
  EGX72_RS11545 - 55713..55856 (-) 144 WP_000564610.1 hypothetical protein -
  EGX72_RS11550 - 55860..56024 (-) 165 WP_162489522.1 hypothetical protein -
  EGX72_RS11555 - 56076..56234 (-) 159 WP_017646174.1 hypothetical protein -
  EGX72_RS00300 (EGX72_00300) - 56218..56514 (-) 297 WP_038405996.1 nucleotide modification associated domain-containing protein -
  EGX72_RS00305 (EGX72_00305) - 56526..56871 (-) 346 Protein_63 hypothetical protein -
  EGX72_RS00310 (EGX72_00310) - 56852..57178 (-) 327 WP_000206193.1 VRR-NUC domain-containing protein -
  EGX72_RS00315 (EGX72_00315) - 57422..58936 (-) 1515 WP_029665793.1 DNA primase family protein -
  EGX72_RS00320 (EGX72_00320) - 58932..59735 (-) 804 WP_123957697.1 bifunctional DNA primase/polymerase -
  EGX72_RS00325 (EGX72_00325) - 59739..60200 (-) 462 WP_000494143.1 DUF669 domain-containing protein -
  EGX72_RS00330 (EGX72_00330) - 60216..61559 (-) 1344 WP_060794304.1 DEAD/DEAH box helicase -
  EGX72_RS00335 (EGX72_00335) - 61546..62238 (-) 693 WP_000704953.1 AAA family ATPase -
  EGX72_RS00340 (EGX72_00340) - 62225..62539 (-) 315 WP_000135595.1 hypothetical protein -
  EGX72_RS00345 (EGX72_00345) - 62622..62930 (-) 309 WP_047198762.1 hypothetical protein -
  EGX72_RS11630 - 63060..63845 (-) 786 WP_253257042.1 polymer-forming cytoskeletal protein -
  EGX72_RS00360 (EGX72_00355) - 63879..64103 (-) 225 WP_000431164.1 hypothetical protein -
  EGX72_RS00365 (EGX72_00360) - 64132..64389 (-) 258 WP_016480517.1 hypothetical protein -
  EGX72_RS00370 (EGX72_00365) - 64468..64644 (-) 177 WP_000728090.1 helix-turn-helix domain-containing protein -
  EGX72_RS11560 - 64759..64935 (+) 177 WP_017645150.1 hypothetical protein -
  EGX72_RS00375 (EGX72_00370) - 64963..65154 (-) 192 WP_001003168.1 hypothetical protein -
  EGX72_RS00380 (EGX72_00375) - 65173..65694 (-) 522 WP_000032137.1 hypothetical protein -
  EGX72_RS00385 (EGX72_00380) - 65687..66646 (-) 960 WP_001156317.1 hypothetical protein -
  EGX72_RS00390 (EGX72_00385) - 66700..66906 (-) 207 WP_000164462.1 helix-turn-helix transcriptional regulator -
  EGX72_RS00395 (EGX72_00390) - 66957..67598 (+) 642 WP_123957698.1 hypothetical protein -
  EGX72_RS00400 (EGX72_00395) - 67696..67854 (-) 159 WP_001104146.1 hypothetical protein -
  EGX72_RS00405 (EGX72_00400) - 67913..68125 (+) 213 WP_047208985.1 hypothetical protein -
  EGX72_RS11565 - 68114..68263 (-) 150 WP_017645151.1 hypothetical protein -
  EGX72_RS00410 (EGX72_00405) - 68624..69403 (+) 780 WP_000095652.1 S24 family peptidase -
  EGX72_RS00420 (EGX72_00415) - 69535..70149 (+) 615 WP_000742866.1 hypothetical protein -
  EGX72_RS00425 (EGX72_00420) - 70322..71419 (+) 1098 WP_000570847.1 site-specific integrase -
  EGX72_RS00430 (EGX72_00425) comX/sigX 71598..72077 (-) 480 WP_001204194.1 sigma-70 family RNA polymerase sigma factor Regulator

Sequence

Protein


Download         Length: 159 a.a.        Molecular weight: 19447.28 Da        Isoelectric Point: 6.2639

>NTDB_id=325860 EGX72_RS00430 WP_001204194.1 71598..72077(-) (comX/sigX) [Streptococcus sp. FDAARGOS_521]
MRDFEELFDKVKPIVMKLRRNYFVQLWEYDDWIQEGRIVLFRLLEEHPYLLDNESKLFIYFKTKFSNYLNDVLRHQDCQK
RQFNKMPYEEISEVSHYVKSKGLVLDDYIAYRDTLTKVEETLSDIDKEKFEKLISGERFAGKKQFIRDIQPFFNAFKAD

Nucleotide


Download         Length: 480 bp        

>NTDB_id=325860 EGX72_RS00430 WP_001204194.1 71598..72077(-) (comX/sigX) [Streptococcus sp. FDAARGOS_521]
TTGAGAGATTTTGAGGAGTTGTTTGATAAAGTAAAGCCAATCGTAATGAAGCTGAGAAGAAATTATTTTGTTCAACTTTG
GGAATATGATGATTGGATTCAAGAAGGACGTATTGTACTTTTTAGGTTGCTTGAAGAGCATCCGTATTTATTGGATAATG
AAAGCAAACTATTCATTTACTTTAAAACAAAATTTTCAAATTATTTAAACGATGTATTAAGACACCAAGATTGTCAAAAG
CGACAATTTAATAAAATGCCTTATGAAGAAATAAGTGAAGTTAGTCACTATGTTAAGAGTAAAGGACTAGTTTTAGATGA
CTATATTGCTTATCGTGATACTTTAACAAAAGTGGAAGAAACTTTGTCAGATATTGATAAAGAAAAATTTGAAAAACTGA
TTAGTGGTGAACGTTTTGCGGGGAAGAAACAATTCATACGAGATATTCAACCCTTTTTCAATGCTTTTAAAGCGGATTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

56.688

98.742

0.56
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

52.349

93.711

0.491
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

52.349

93.711

0.491
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

52

94.34

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

52

94.34

0.491
  comX/sigX Streptococcus mutans UA159

49.677

97.484

0.484
  comX Streptococcus sobrinus strain NIDR 6715-7

43.59

98.113

0.428
  comX/sigX Streptococcus suis D9

43.226

97.484

0.421
  comX/sigX Streptococcus suis isolate S10

43.226

97.484

0.421
  comX/sigX Streptococcus suis P1/7

43.226

97.484

0.421
  comX Streptococcus thermophilus LMD-9

42.177

92.453

0.39
  comX Streptococcus thermophilus LMG 18311

42.177

92.453

0.39
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

39.869

96.226

0.384
  comX/comX2 Streptococcus pneumoniae Rx1

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae Rx1

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae D39

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae D39

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae R6

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae R6

40.397

94.969

0.384
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

39.216

96.226

0.377
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

39.216

96.226

0.377
  comX Streptococcus salivarius SK126

40.816

92.453

0.377
  comX/sigX Streptococcus salivarius strain HSISS4

40.816

92.453

0.377
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

38.562

96.226

0.371

Multiple sequence alignment