Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   CVO91_RS00085 Genome accession   NZ_CP024974
Coordinates   17407..17877 (+) Length   156 a.a.
NCBI ID   WP_002936602.1    Uniprot ID   A0A075SE61
Organism   Streptococcus suis strain CZ130302     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 15082..49563 17407..17877 within 0


Gene organization within MGE regions


Location: 15082..49563
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CVO91_RS00080 (CVO91_00080) ftsH 15082..17055 (+) 1974 WP_004195369.1 ATP-dependent zinc metalloprotease FtsH -
  CVO91_RS00085 (CVO91_00085) comX/sigX 17407..17877 (+) 471 WP_002936602.1 sigma-70 family RNA polymerase sigma factor Regulator
  CVO91_RS00190 (CVO91_00190) mreC 25163..25999 (+) 837 WP_004195372.1 rod shape-determining protein MreC -
  CVO91_RS00195 (CVO91_00195) mreD 25989..26504 (+) 516 WP_004195373.1 rod shape-determining protein MreD -
  CVO91_RS00200 (CVO91_00200) - 26589..27821 (+) 1233 WP_004195374.1 CHAP domain-containing protein -
  CVO91_RS00205 (CVO91_00205) - 27952..28920 (+) 969 WP_004195376.1 ribose-phosphate diphosphokinase -
  CVO91_RS00210 (CVO91_00210) - 29007..30185 (+) 1179 WP_004195378.1 pyridoxal phosphate-dependent aminotransferase -
  CVO91_RS00215 (CVO91_00215) recO 30172..30936 (+) 765 WP_100664705.1 DNA repair protein RecO -
  CVO91_RS00220 (CVO91_00220) - 30948..31289 (-) 342 WP_004195383.1 hypothetical protein -
  CVO91_RS00225 (CVO91_00225) comE/blpR 31396..32130 (+) 735 WP_004195385.1 response regulator transcription factor Regulator
  CVO91_RS00230 (CVO91_00230) - 32127..33491 (+) 1365 WP_004195387.1 GHKL domain-containing protein -
  CVO91_RS00235 (CVO91_00235) - 33814..34551 (+) 738 WP_004195389.1 hypothetical protein -
  CVO91_RS00240 (CVO91_00240) - 34579..35454 (+) 876 WP_004195391.1 ABC transporter ATP-binding protein -
  CVO91_RS00245 (CVO91_00245) - 35456..36229 (+) 774 WP_004195393.1 hypothetical protein -
  CVO91_RS00250 (CVO91_00250) plsX 36352..37359 (+) 1008 WP_004195395.1 phosphate acyltransferase PlsX -
  CVO91_RS00255 (CVO91_00255) - 37352..37600 (+) 249 WP_004195397.1 phosphopantetheine-binding protein -
  CVO91_RS00260 (CVO91_00260) purC 37718..38425 (+) 708 WP_004195398.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  CVO91_RS00265 (CVO91_00265) - 38438..42157 (+) 3720 WP_024378576.1 phosphoribosylformylglycinamidine synthase -
  CVO91_RS00270 (CVO91_00270) purF 42160..43614 (+) 1455 WP_004195403.1 amidophosphoribosyltransferase -
  CVO91_RS00275 (CVO91_00275) purM 43670..44692 (+) 1023 WP_004195405.1 phosphoribosylformylglycinamidine cyclo-ligase -
  CVO91_RS00280 (CVO91_00280) purN 44689..45258 (+) 570 WP_004195407.1 phosphoribosylglycinamide formyltransferase -
  CVO91_RS00285 (CVO91_00285) - 45240..46313 (+) 1074 WP_004195409.1 hypothetical protein -
  CVO91_RS00290 (CVO91_00290) purH 46316..47863 (+) 1548 WP_004195412.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  CVO91_RS00295 (CVO91_00295) - 47928..48758 (+) 831 WP_004195413.1 DNA adenine methylase -
  CVO91_RS00300 (CVO91_00300) - 48748..49563 (+) 816 WP_032499218.1 site-specific DNA-methyltransferase -

Sequence

Protein


Download         Length: 156 a.a.        Molecular weight: 19072.97 Da        Isoelectric Point: 8.9339

>NTDB_id=256899 CVO91_RS00085 WP_002936602.1 17407..17877(+) (comX/sigX) [Streptococcus suis strain CZ130302]
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKR
KFDRMPHEDIHELSHAIQSPGLINDELLMLRGALRDYRKNLSNDQLDKYEKLISGQCFNGRREMIRDLQIHLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=256899 CVO91_RS00085 WP_002936602.1 17407..17877(+) (comX/sigX) [Streptococcus suis strain CZ130302]
ATGGAATTCGAAAAAGTGTACGCAAGCGTCAAAGGTATTGTAAACAAGGCTCGAAAAGAGTTTTACATTAAATTATGGGA
TCGAGATGATTGGGAACAAGAAGGAATGATGACCTTGTTTGAATTATTGGAAGCTCAACCGTGGCTAGTTGATGAACAAG
TTCAATTATATTGTTACTTTAAAGTCAAGTTCAGAAATCGCATCAAAGATCGTATCCGCAAACAGGAAAGTCAAAAACGC
AAGTTTGACCGAATGCCACATGAAGATATTCACGAATTATCTCATGCAATACAATCACCGGGATTGATAAACGATGAACT
ATTAATGTTGAGAGGTGCCTTGAGAGATTATCGAAAAAATCTGAGTAATGATCAACTTGATAAATACGAAAAATTAATTA
GCGGACAATGTTTTAATGGTCGTCGTGAAATGATACGTGATTTACAAATTCATTTGAAAGACTTTCGCTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A075SE61

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

100

100

1
  comX/sigX Streptococcus suis isolate S10

99.359

100

0.994
  comX/sigX Streptococcus suis P1/7

99.359

100

0.994
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487
  comX/comX1 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449
  comX/comX2 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

45.752

98.077

0.449
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/comX1 Streptococcus pneumoniae Rx1

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae D39

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae D39

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae R6

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae R6

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae Rx1

45.695

96.795

0.442
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

44.444

98.077

0.436
  comX/sigX Streptococcus mutans UA159

43.226

99.359

0.429
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX Streptococcus sobrinus strain NIDR 6715-7

40.523

98.077

0.397
  comX Streptococcus thermophilus LMG 18311

40.523

98.077

0.397
  comX Streptococcus thermophilus LMD-9

40.523

98.077

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.854

100

0.391
  comX Streptococcus salivarius SK126

39.869

98.077

0.391
  comX/sigX Streptococcus salivarius strain HSISS4

39.869

98.077

0.391

Multiple sequence alignment