Detailed information NTG0256900

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: CVO91_RS00225
• Genome accession: NZ_CP024974
• Coordinates: 31396..32130 (+)
• Length: 244 a.a.
• NCBI ID: WP_004195385.1
• Uniprot ID: A0AA87K3P9
• Organism: Streptococcus suis strain CZ130302
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	15082..49563	31396..32130	within	0

Gene organization within MGE regions

Location: 15082..49563

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CVO91_RS00080 (CVO91_00080)	ftsH	15082..17055 (+)	1974	WP_004195369.1	ATP-dependent zinc metalloprotease FtsH	-
CVO91_RS00085 (CVO91_00085)	comX/sigX	17407..17877 (+)	471	WP_002936602.1	sigma-70 family RNA polymerase sigma factor	Regulator
CVO91_RS00190 (CVO91_00190)	mreC	25163..25999 (+)	837	WP_004195372.1	rod shape-determining protein MreC	-
CVO91_RS00195 (CVO91_00195)	mreD	25989..26504 (+)	516	WP_004195373.1	rod shape-determining protein MreD	-
CVO91_RS00200 (CVO91_00200)	-	26589..27821 (+)	1233	WP_004195374.1	CHAP domain-containing protein	-
CVO91_RS00205 (CVO91_00205)	-	27952..28920 (+)	969	WP_004195376.1	ribose-phosphate diphosphokinase	-
CVO91_RS00210 (CVO91_00210)	-	29007..30185 (+)	1179	WP_004195378.1	pyridoxal phosphate-dependent aminotransferase	-
CVO91_RS00215 (CVO91_00215)	recO	30172..30936 (+)	765	WP_100664705.1	DNA repair protein RecO	-
CVO91_RS00220 (CVO91_00220)	-	30948..31289 (-)	342	WP_004195383.1	hypothetical protein	-
CVO91_RS00225 (CVO91_00225)	comE/blpR	31396..32130 (+)	735	WP_004195385.1	response regulator transcription factor	Regulator
CVO91_RS00230 (CVO91_00230)	-	32127..33491 (+)	1365	WP_004195387.1	GHKL domain-containing protein	-
CVO91_RS00235 (CVO91_00235)	-	33814..34551 (+)	738	WP_004195389.1	hypothetical protein	-
CVO91_RS00240 (CVO91_00240)	-	34579..35454 (+)	876	WP_004195391.1	ABC transporter ATP-binding protein	-
CVO91_RS00245 (CVO91_00245)	-	35456..36229 (+)	774	WP_004195393.1	hypothetical protein	-
CVO91_RS00250 (CVO91_00250)	plsX	36352..37359 (+)	1008	WP_004195395.1	phosphate acyltransferase PlsX	-
CVO91_RS00255 (CVO91_00255)	-	37352..37600 (+)	249	WP_004195397.1	phosphopantetheine-binding protein	-
CVO91_RS00260 (CVO91_00260)	purC	37718..38425 (+)	708	WP_004195398.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CVO91_RS00265 (CVO91_00265)	-	38438..42157 (+)	3720	WP_024378576.1	phosphoribosylformylglycinamidine synthase	-
CVO91_RS00270 (CVO91_00270)	purF	42160..43614 (+)	1455	WP_004195403.1	amidophosphoribosyltransferase	-
CVO91_RS00275 (CVO91_00275)	purM	43670..44692 (+)	1023	WP_004195405.1	phosphoribosylformylglycinamidine cyclo-ligase	-
CVO91_RS00280 (CVO91_00280)	purN	44689..45258 (+)	570	WP_004195407.1	phosphoribosylglycinamide formyltransferase	-
CVO91_RS00285 (CVO91_00285)	-	45240..46313 (+)	1074	WP_004195409.1	hypothetical protein	-
CVO91_RS00290 (CVO91_00290)	purH	46316..47863 (+)	1548	WP_004195412.1	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	-
CVO91_RS00295 (CVO91_00295)	-	47928..48758 (+)	831	WP_004195413.1	DNA adenine methylase	-
CVO91_RS00300 (CVO91_00300)	-	48748..49563 (+)	816	WP_032499218.1	site-specific DNA-methyltransferase	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28078.08 Da
• Isoelectric Point: 5.2193

>NTDB_id=256900 CVO91_RS00225 WP_004195385.1 31396..32130(+) (comE/blpR) [Streptococcus suis strain CZ130302]
MLRIFILEDDFMQQARLEQAIEEVVKTSDVAYKTLEVFGKPQQLLEAVTETGNHQLFFLDIEIRGEEKKGMEIAREIRAR
DPHAVIVFVTTHSEFMPLTYKYRVSALDFIDKGLDEPAFKEAVADVLQHAYSHISQTVSDDAFVFKSEFSQIQVPFSDIL
YFETSSTPHKVVLTTKLGHTEFYGKVSDIAKTDERLYQSHRAYVVNPANILRVDAVERMVYFEQEESCLVSRMKLKGLLE
RVGK

Nucleotide

• Length: 735 bp

>NTDB_id=256900 CVO91_RS00225 WP_004195385.1 31396..32130(+) (comE/blpR) [Streptococcus suis strain CZ130302]
ATGTTACGGATTTTTATCTTGGAAGATGATTTTATGCAACAAGCTAGGTTGGAGCAGGCGATTGAGGAAGTTGTAAAAAC
GAGTGACGTTGCCTATAAGACCTTAGAAGTTTTTGGTAAACCTCAGCAGTTATTAGAGGCTGTGACAGAGACTGGAAATC
ATCAGCTCTTTTTCCTAGATATTGAGATTAGAGGTGAGGAGAAGAAAGGGATGGAGATTGCACGGGAGATAAGAGCGCGT
GATCCGCATGCTGTGATTGTTTTTGTGACGACACATTCGGAGTTTATGCCTTTGACCTATAAATACCGTGTGTCGGCTCT
TGATTTTATTGATAAGGGGTTGGATGAGCCTGCCTTTAAGGAAGCAGTGGCAGATGTTCTCCAACATGCTTATAGTCATA
TCAGTCAGACTGTGAGCGATGATGCTTTTGTTTTCAAGAGTGAGTTTTCTCAGATTCAGGTGCCGTTTTCAGATATTTTG
TATTTTGAAACCTCTTCAACGCCTCATAAGGTCGTCTTGACAACCAAGTTAGGTCATACAGAGTTTTATGGCAAGGTGTC
GGATATTGCTAAAACGGATGAACGATTGTACCAGAGCCATCGGGCTTATGTGGTCAATCCTGCTAATATTCTTCGTGTGG
ATGCTGTGGAGCGGATGGTGTATTTTGAACAGGAGGAATCTTGCTTGGTCTCTCGAATGAAACTGAAAGGTTTGCTAGAG
AGGGTTGGGAAATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-241)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.23	97.951	0.541
comE/comE1	Streptococcus equinus JB1	45.607	97.951	0.447
comE/comE2	Streptococcus equinus JB1	40.336	97.541	0.393
comE	Streptococcus infantis strain Atu-4	36.905	100	0.381
comE/comE2	Streptococcus gordonii strain NCTC7865	37.86	99.59	0.377
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.86	99.59	0.377
comE	Streptococcus mitis NCTC 12261	37.449	99.59	0.373
comE	Streptococcus mitis SK321	37.449	99.59	0.373
comE	Streptococcus pneumoniae Rx1	37.449	99.59	0.373
comE	Streptococcus pneumoniae D39	37.449	99.59	0.373
comE	Streptococcus pneumoniae R6	37.449	99.59	0.373
comE	Streptococcus pneumoniae TIGR4	37.449	99.59	0.373