Detailed information    

insolico Bioinformatically predicted

Overview


Name   comX/sigX   Type   Regulator
Locus tag   ACM3H0_RS00700 Genome accession   NZ_CP180685
Coordinates   100782..101261 (+) Length   159 a.a.
NCBI ID   WP_001204194.1    Uniprot ID   A0AAV3JNR5
Organism   Streptococcus agalactiae strain M14     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 101440..145850 100782..101261 flank 179


Gene organization within MGE regions


Location: 100782..145850
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACM3H0_RS00700 (ACM3H0_00700) comX/sigX 100782..101261 (+) 480 WP_001204194.1 sigma-70 family RNA polymerase sigma factor Regulator
  ACM3H0_RS00705 (ACM3H0_00705) - 101440..102537 (-) 1098 WP_000570847.1 site-specific integrase -
  ACM3H0_RS00710 (ACM3H0_00710) - 102710..103603 (-) 894 WP_000426896.1 P63C domain-containing protein -
  ACM3H0_RS00715 (ACM3H0_00715) - 103775..104332 (-) 558 WP_000891065.1 hypothetical protein -
  ACM3H0_RS00720 (ACM3H0_00720) - 104334..105077 (-) 744 WP_416055431.1 XRE family transcriptional regulator -
  ACM3H0_RS00725 (ACM3H0_00725) - 105437..105586 (+) 150 WP_017645151.1 hypothetical protein -
  ACM3H0_RS00730 (ACM3H0_00730) - 105575..105787 (-) 213 WP_000703681.1 hypothetical protein -
  ACM3H0_RS00735 (ACM3H0_00735) - 105846..106004 (+) 159 WP_001104143.1 hypothetical protein -
  ACM3H0_RS00740 (ACM3H0_00740) - 106102..106743 (-) 642 WP_001008979.1 hypothetical protein -
  ACM3H0_RS00745 (ACM3H0_00745) - 106960..107295 (-) 336 WP_000360289.1 hypothetical protein -
  ACM3H0_RS00750 (ACM3H0_00750) - 107371..107586 (+) 216 WP_000164461.1 helix-turn-helix transcriptional regulator -
  ACM3H0_RS00755 (ACM3H0_00755) - 107604..108527 (+) 924 WP_416055441.1 DUF3102 domain-containing protein -
  ACM3H0_RS00760 (ACM3H0_00760) - 108524..108979 (+) 456 WP_001872799.1 ORF6C domain-containing protein -
  ACM3H0_RS00765 (ACM3H0_00765) - 109011..109169 (+) 159 WP_000392121.1 hypothetical protein -
  ACM3H0_RS00770 (ACM3H0_00770) - 109296..109442 (+) 147 WP_001867241.1 hypothetical protein -
  ACM3H0_RS00775 (ACM3H0_00775) - 109405..109713 (-) 309 WP_001000651.1 hypothetical protein -
  ACM3H0_RS00780 (ACM3H0_00780) - 109823..110080 (+) 258 WP_016480517.1 hypothetical protein -
  ACM3H0_RS00785 (ACM3H0_00785) - 110109..110333 (+) 225 WP_047208982.1 hypothetical protein -
  ACM3H0_RS00790 (ACM3H0_00790) - 110408..111166 (+) 759 WP_000546751.1 DnaD domain protein -
  ACM3H0_RS00795 (ACM3H0_00795) - 111153..111935 (+) 783 WP_000600243.1 ATP-binding protein -
  ACM3H0_RS00800 (ACM3H0_00800) - 111926..112072 (+) 147 WP_165694407.1 hypothetical protein -
  ACM3H0_RS00805 (ACM3H0_00805) - 112062..112337 (+) 276 WP_000431575.1 hypothetical protein -
  ACM3H0_RS00810 (ACM3H0_00810) - 112324..112578 (+) 255 WP_047200442.1 hypothetical protein -
  ACM3H0_RS00815 (ACM3H0_00815) - 112580..112741 (+) 162 WP_079398808.1 hypothetical protein -
  ACM3H0_RS00820 (ACM3H0_00820) - 112743..113072 (+) 330 WP_047200443.1 hypothetical protein -
  ACM3H0_RS00825 (ACM3H0_00825) - 113075..114055 (+) 981 WP_047200444.1 recombinase RecT -
  ACM3H0_RS00830 (ACM3H0_00830) - 114052..114849 (+) 798 WP_047200445.1 PD-(D/E)XK nuclease-like domain-containing protein -
  ACM3H0_RS00835 (ACM3H0_00835) - 115010..115207 (+) 198 WP_000474006.1 hypothetical protein -
  ACM3H0_RS00840 (ACM3H0_00840) - 115197..115672 (+) 476 Protein_117 RusA family crossover junction endodeoxyribonuclease -
  ACM3H0_RS00845 (ACM3H0_00845) - 115662..116009 (+) 348 WP_047200446.1 hypothetical protein -
  ACM3H0_RS00850 (ACM3H0_00850) - 116021..116308 (+) 288 WP_071661630.1 nucleotide modification associated domain-containing protein -
  ACM3H0_RS00855 (ACM3H0_00855) - 116457..116897 (+) 441 WP_000612732.1 YopX family protein -
  ACM3H0_RS00860 (ACM3H0_00860) - 117021..117164 (+) 144 WP_000564605.1 hypothetical protein -
  ACM3H0_RS00865 (ACM3H0_00865) - 117161..117661 (+) 501 WP_416055430.1 DUF1642 domain-containing protein -
  ACM3H0_RS00870 (ACM3H0_00870) - 117682..117981 (+) 300 WP_079218641.1 hypothetical protein -
  ACM3H0_RS00875 (ACM3H0_00875) - 117999..118265 (+) 267 WP_416055429.1 hypothetical protein -
  ACM3H0_RS00880 (ACM3H0_00880) - 118656..119090 (+) 435 WP_000142570.1 ArpU family phage packaging/lysis transcriptional regulator -
  ACM3H0_RS00890 (ACM3H0_00890) - 119646..119774 (+) 129 WP_017647279.1 hypothetical protein -
  ACM3H0_RS00895 (ACM3H0_00895) - 119828..120205 (-) 378 WP_000964195.1 type II toxin-antitoxin system HicB family antitoxin -
  ACM3H0_RS00900 (ACM3H0_00900) - 120258..120443 (-) 186 WP_001132272.1 type II toxin-antitoxin system HicA family toxin -
  ACM3H0_RS00905 (ACM3H0_00905) - 120544..120882 (+) 339 WP_001247768.1 HNH endonuclease -
  ACM3H0_RS00910 (ACM3H0_00910) - 121054..121521 (+) 468 WP_000532791.1 phage terminase small subunit P27 family -
  ACM3H0_RS00915 (ACM3H0_00915) - 121536..123290 (+) 1755 WP_000151569.1 terminase large subunit -
  ACM3H0_RS00920 (ACM3H0_00920) - 123287..123454 (+) 168 WP_000578945.1 hypothetical protein -
  ACM3H0_RS00925 (ACM3H0_00925) - 123451..123681 (+) 231 WP_001042284.1 hypothetical protein -
  ACM3H0_RS00930 (ACM3H0_00930) - 123688..124908 (+) 1221 WP_000007732.1 phage portal protein -
  ACM3H0_RS00935 (ACM3H0_00935) - 124886..125551 (+) 666 WP_071661629.1 head maturation protease, ClpP-related -
  ACM3H0_RS00940 (ACM3H0_00940) - 125575..126756 (+) 1182 WP_416055428.1 phage major capsid protein -
  ACM3H0_RS00945 (ACM3H0_00945) - 126892..127194 (+) 303 WP_416055427.1 head-tail connector protein -
  ACM3H0_RS00950 (ACM3H0_00950) - 127191..127538 (+) 348 WP_000632972.1 phage head closure protein -
  ACM3H0_RS00955 (ACM3H0_00955) - 127535..127912 (+) 378 WP_000160228.1 HK97-gp10 family putative phage morphogenesis protein -
  ACM3H0_RS00960 (ACM3H0_00960) - 127909..128334 (+) 426 WP_000559944.1 hypothetical protein -
  ACM3H0_RS00965 (ACM3H0_00965) - 128350..128970 (+) 621 Protein_141 major tail protein -
  ACM3H0_RS00970 (ACM3H0_00970) gpG 129024..129359 (+) 336 WP_410531500.1 phage tail assembly chaperone G -
  ACM3H0_RS00975 (ACM3H0_00975) - 129373..129540 (+) 168 WP_000264971.1 hypothetical protein -
  ACM3H0_RS00980 (ACM3H0_00980) - 129553..133493 (+) 3941 Protein_144 phage tail tape measure protein -
  ACM3H0_RS00985 (ACM3H0_00985) - 133490..135012 (+) 1523 Protein_145 distal tail protein Dit -
  ACM3H0_RS00990 (ACM3H0_00990) - 135003..138830 (+) 3828 WP_050977836.1 glucosaminidase domain-containing protein -
  ACM3H0_RS00995 (ACM3H0_00995) - 138841..140853 (+) 2013 WP_050977837.1 DUF859 family phage minor structural protein -
  ACM3H0_RS01000 (ACM3H0_01000) - 140867..141193 (+) 327 WP_000404431.1 DUF1366 domain-containing protein -
  ACM3H0_RS01005 (ACM3H0_01005) - 141168..141380 (+) 213 WP_000698337.1 hypothetical protein -
  ACM3H0_RS01010 (ACM3H0_01010) - 141393..141695 (+) 303 WP_000215499.1 hypothetical protein -
  ACM3H0_RS01015 (ACM3H0_01015) - 141697..141951 (+) 255 WP_000611524.1 phage holin -
  ACM3H0_RS01020 (ACM3H0_01020) - 142077..143411 (+) 1335 WP_336317628.1 GH25 family lysozyme -
  ACM3H0_RS01025 (ACM3H0_01025) - 143541..144437 (+) 897 WP_001061853.1 sensor histidine kinase -
  ACM3H0_RS01030 (ACM3H0_01030) - 144431..144730 (+) 300 WP_000258211.1 STAS-like domain-containing protein -
  ACM3H0_RS01035 (ACM3H0_01035) - 144839..145039 (+) 201 WP_000076715.1 CsbD family protein -
  ACM3H0_RS01040 (ACM3H0_01040) - 145080..145250 (-) 171 WP_000356856.1 hypothetical protein -
  ACM3H0_RS01045 (ACM3H0_01045) prx 145668..145850 (+) 183 WP_000965649.1 hypothetical protein Regulator

Sequence


Protein


Download         Length: 159 a.a.        Molecular weight: 19447.28 Da        Isoelectric Point: 6.2639

>NTDB_id=1097389 ACM3H0_RS00700 WP_001204194.1 100782..101261(+) (comX/sigX) [Streptococcus agalactiae strain M14]
MRDFEELFDKVKPIVMKLRRNYFVQLWEYDDWIQEGRIVLFRLLEEHPYLLDNESKLFIYFKTKFSNYLNDVLRHQDCQK
RQFNKMPYEEISEVSHYVKSKGLVLDDYIAYRDTLTKVEETLSDIDKEKFEKLISGERFAGKKQFIRDIQPFFNAFKAD

Nucleotide


Download         Length: 480 bp        

>NTDB_id=1097389 ACM3H0_RS00700 WP_001204194.1 100782..101261(+) (comX/sigX) [Streptococcus agalactiae strain M14]
TTGAGAGATTTTGAGGAGTTGTTTGATAAAGTAAAGCCAATCGTAATGAAGCTGAGAAGAAATTATTTTGTTCAACTTTG
GGAATATGATGATTGGATTCAAGAAGGGCGTATTGTACTTTTTAGGTTGCTTGAAGAACATCCGTATTTATTGGATAATG
AAAGCAAACTATTCATTTACTTTAAAACAAAATTTTCAAATTATTTAAACGATGTATTAAGACATCAAGATTGTCAAAAG
CGACAATTTAATAAAATGCCTTATGAAGAAATCAGTGAAGTTAGTCACTATGTTAAGAGTAAAGGACTAGTTTTAGATGA
CTATATTGCTTATCGTGATACTTTAACAAAAGTGGAAGAAACTTTGTCAGATATTGATAAAGAAAAATTTGAAAAACTGA
TTAGTGGTGAACGTTTCGCGGGGAAGAAACAATTCATACGAGATATTCAACCTTTTTTCAATGCTTTTAAAGCGGATTAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

56.688

98.742

0.56

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

52.349

93.711

0.491

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

52.349

93.711

0.491

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

52

94.34

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

52

94.34

0.491

  comX/sigX Streptococcus mutans UA159

49.677

97.484

0.484

  comX Streptococcus sobrinus strain NIDR 6715-7

43.59

98.113

0.428

  comX/sigX Streptococcus suis D9

43.226

97.484

0.421

  comX/sigX Streptococcus suis isolate S10

43.226

97.484

0.421

  comX/sigX Streptococcus suis P1/7

43.226

97.484

0.421

  comX Streptococcus thermophilus LMD-9

42.177

92.453

0.39

  comX Streptococcus thermophilus LMG 18311

42.177

92.453

0.39

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384

  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

39.869

96.226

0.384

  comX/comX2 Streptococcus pneumoniae Rx1

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae Rx1

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae D39

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae D39

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae R6

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae R6

40.397

94.969

0.384

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

39.216

96.226

0.377

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

39.216

96.226

0.377

  comX Streptococcus salivarius SK126

40.816

92.453

0.377

  comX/sigX Streptococcus salivarius strain HSISS4

40.816

92.453

0.377

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

38.562

96.226

0.371


Multiple sequence alignment