Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   L6411_RS00450 Genome accession   NZ_AP025333
Coordinates   72942..73412 (+) Length   156 a.a.
NCBI ID   WP_024532329.1    Uniprot ID   A0A2Z5TJY2
Organism   Streptococcus ruminantium strain GUT-189     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 67942..78412
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L6411_RS00420 (GUT189_00640) recA 68854..69996 (+) 1143 WP_024532325.1 recombinase RecA Machinery gene
  L6411_RS00425 (GUT189_00650) spx 70525..70923 (+) 399 WP_024532326.1 transcriptional regulator Spx -
  L6411_RS00430 (GUT189_00660) - 71027..71293 (+) 267 WP_002939360.1 IreB family regulatory phosphoprotein -
  L6411_RS00435 (GUT189_00670) ruvX 71293..71712 (+) 420 WP_032537883.1 Holliday junction resolvase RuvX -
  L6411_RS00440 (GUT189_00680) - 71724..72029 (+) 306 WP_024532328.1 DUF1292 domain-containing protein -
  L6411_RS00445 (GUT189_00690) - 72304..72849 (+) 546 WP_237374195.1 nucleotidyltransferase family protein -
  L6411_RS00450 (GUT189_00700) comX/sigX 72942..73412 (+) 471 WP_024532329.1 sigma-70 family RNA polymerase sigma factor Regulator
  L6411_RS00455 (GUT189_00710) rpsJ 73946..74254 (+) 309 WP_002939332.1 30S ribosomal protein S10 -
  L6411_RS00460 (GUT189_00720) rplC 74520..75146 (+) 627 WP_237374196.1 50S ribosomal protein L3 -
  L6411_RS00465 (GUT189_00730) rplD 75171..75794 (+) 624 WP_024532331.1 50S ribosomal protein L4 -
  L6411_RS00470 (GUT189_00740) - 75794..76093 (+) 300 WP_024379978.1 50S ribosomal protein L23 -
  L6411_RS00475 (GUT189_00750) rplB 76111..76944 (+) 834 WP_024532332.1 50S ribosomal protein L2 -
  L6411_RS00480 (GUT189_00760) rpsS 77035..77316 (+) 282 WP_000533766.1 30S ribosomal protein S19 -
  L6411_RS00485 (GUT189_00770) rplV 77334..77678 (+) 345 WP_002936662.1 50S ribosomal protein L22 -
  L6411_RS00490 (GUT189_00780) rpsC 77691..78344 (+) 654 WP_024391478.1 30S ribosomal protein S3 -

Sequence

Protein


Download         Length: 156 a.a.        Molecular weight: 18952.94 Da        Isoelectric Point: 9.4931

>NTDB_id=91215 L6411_RS00450 WP_024532329.1 72942..73412(+) (comX/sigX) [Streptococcus ruminantium strain GUT-189]
MEFEKVYSKVKGIVHKARKDFYVKLWEKGDWEQEGMMVLFELLDAQPNLLEESDRLYCYFKVKFRNHIKDVIRKQESQKR
KFDRMAHEEIHGLSHMIQSPGLINDELLMLRAALREYRKNLSPSQQENYEKLMSGQCFNGRRKMIRDLQEYLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=91215 L6411_RS00450 WP_024532329.1 72942..73412(+) (comX/sigX) [Streptococcus ruminantium strain GUT-189]
ATGGAATTTGAAAAGGTTTATTCAAAAGTGAAAGGGATCGTTCACAAGGCTCGTAAAGATTTTTATGTCAAACTATGGGA
AAAGGGAGACTGGGAGCAAGAAGGGATGATGGTCTTGTTTGAATTATTGGATGCACAACCAAATCTCTTGGAGGAGTCTG
ATAGATTATACTGTTATTTCAAGGTGAAATTTAGAAACCATATCAAAGATGTGATTCGCAAACAAGAAAGTCAGAAGCGA
AAATTTGATCGAATGGCGCACGAAGAAATTCATGGTCTCTCACACATGATTCAATCACCTGGTCTAATCAATGATGAGTT
ATTGATGCTGCGAGCTGCTTTGAGAGAGTACCGGAAAAATCTTTCACCGAGCCAGCAAGAAAATTATGAAAAACTCATGA
GTGGTCAATGTTTCAATGGTCGTCGCAAAATGATTCGTGACCTGCAGGAATACTTGAAAGATTTTCGCTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TJY2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

78.846

100

0.788
  comX/sigX Streptococcus suis isolate S10

78.205

100

0.782
  comX/sigX Streptococcus suis P1/7

78.205

100

0.782
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

52.903

99.359

0.526
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

52.903

99.359

0.526
  comX/sigX Streptococcus mutans UA159

45.161

99.359

0.449
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

44.444

98.077

0.436
  comX/comX2 Streptococcus pneumoniae TIGR4

44.371

96.795

0.429
  comX/comX1 Streptococcus pneumoniae TIGR4

44.371

96.795

0.429
  comX/comX2 Streptococcus pneumoniae R6

43.709

96.795

0.423
  comX/comX2 Streptococcus pneumoniae Rx1

43.709

96.795

0.423
  comX/comX1 Streptococcus pneumoniae Rx1

43.709

96.795

0.423
  comX/comX2 Streptococcus pneumoniae D39

43.709

96.795

0.423
  comX/comX1 Streptococcus pneumoniae D39

43.709

96.795

0.423
  comX/comX1 Streptococcus pneumoniae R6

43.709

96.795

0.423
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

43.137

98.077

0.423
  comX Streptococcus sobrinus strain NIDR 6715-7

41.83

98.077

0.41
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

39.49

100

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

39.355

99.359

0.391
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

39.355

99.359

0.391
  comX Streptococcus thermophilus LMD-9

39.869

98.077

0.391
  comX Streptococcus thermophilus LMG 18311

39.869

98.077

0.391
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

38.71

99.359

0.385
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

38.71

99.359

0.385
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

38.71

99.359

0.385
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

38.71

99.359

0.385
  comX/sigX Streptococcus salivarius strain HSISS4

37.908

98.077

0.372
  comX Streptococcus salivarius SK126

37.908

98.077

0.372

Multiple sequence alignment