Detailed information NTG0895874

Bioinformatically predicted

Overview

• Name: comGC/cglC
• Type: Machinery gene
• Locus tag: R4712_RS06260
• Genome accession: NZ_CP137110
• Coordinates: 1242359..1242685 (+)
• Length: 108 a.a.
• NCBI ID: WP_000738626.1
• Uniprot ID: Q8DN88
• Organism: Streptococcus pneumoniae strain 16H2041
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1237359..1247685

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4712_RS06235	nagA	1237488..1238639 (+)	1152	WP_001134457.1	N-acetylglucosamine-6-phosphate deacetylase	-
R4712_RS06240	-	1238802..1239860 (+)	1059	WP_044812807.1	zinc-dependent alcohol dehydrogenase family protein	-
R4712_RS06245	-	1240011..1240376 (+)	366	WP_000286415.1	DUF1033 family protein	-
R4712_RS06250	comGA/cglA/cilD	1240452..1241393 (+)	942	WP_016398028.1	competence type IV pilus ATPase ComGA	Machinery gene
R4712_RS06255	comGB/cglB	1241341..1242357 (+)	1017	WP_074196785.1	competence type IV pilus assembly protein ComGB	Machinery gene
R4712_RS06260	comGC/cglC	1242359..1242685 (+)	327	WP_000738626.1	comG operon protein ComGC	Machinery gene
R4712_RS06265	comGD/cglD	1242678..1243082 (+)	405	WP_288176807.1	competence type IV pilus minor pilin ComGD	Machinery gene
R4712_RS06270	comGE/cglE	1243045..1243347 (+)	303	WP_000413382.1	competence type IV pilus minor pilin ComGE	Machinery gene
R4712_RS06275	comGF/cglF	1243310..1243771 (+)	462	WP_001864569.1	competence type IV pilus minor pilin ComGF	Machinery gene
R4712_RS06280	comGG/cglG	1243749..1244162 (+)	414	WP_001864570.1	competence type IV pilus minor pilin ComGG	Machinery gene
R4712_RS06285	-	1244299..1244893 (+)	595	Protein_1230	class I SAM-dependent methyltransferase	-
R4712_RS06290	comYH	1244954..1245907 (+)	954	WP_001866278.1	class I SAM-dependent methyltransferase	Machinery gene
R4712_RS06295	-	1245958..1247148 (+)	1191	WP_000167766.1	acetate kinase	-
R4712_RS06300	-	1247149..1247280 (+)	132	WP_000768904.1	hypothetical protein	-
R4712_RS06305	rnpA	1247297..1247668 (+)	372	WP_000739246.1	ribonuclease P protein component	-

Sequence

Protein

• Length: 108 a.a.
• Molecular weight: 12200.38 Da
• Isoelectric Point: 10.1877

>NTDB_id=895874 R4712_RS06260 WP_000738626.1 1242359..1242685(+) (comGC/cglC) [Streptococcus pneumoniae strain 16H2041]
MKKMMTFLKKAKVKAFTLVEMLVVLLIISVLFLLFVPNLTKQKEAVNDKGKAAVVKVVESQAELYSLEKNEDASLRKLQA
DGRITEEQAKAYKEYHDKNGGANRKVND

Nucleotide

• Length: 327 bp

>NTDB_id=895874 R4712_RS06260 WP_000738626.1 1242359..1242685(+) (comGC/cglC) [Streptococcus pneumoniae strain 16H2041]
ATGAAAAAAATGATGACATTCTTGAAAAAAGCTAAGGTTAAAGCTTTTACATTGGTGGAGATGTTGGTGGTCTTGCTGAT
TATCAGCGTGCTTTTCTTGCTCTTTGTACCTAATCTGACCAAGCAAAAAGAAGCAGTCAATGACAAAGGAAAAGCAGCTG
TTGTTAAGGTGGTGGAAAGCCAGGCAGAACTTTATAGCTTAGAAAAGAATGAAGATGCTAGCCTAAGAAAGTTACAAGCA
GATGGACGCATCACGGAAGAACAGGCTAAAGCTTATAAAGAATACCATGATAAAAATGGAGGGGCAAATCGTAAAGTCAA
TGATTAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (11-34)

3D structure

• PDB: 6Y1H

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC/cglC	Streptococcus pneumoniae Rx1	100	100	1
comGC/cglC	Streptococcus pneumoniae D39	100	100	1
comGC/cglC	Streptococcus pneumoniae R6	100	100	1
comGC/cglC	Streptococcus pneumoniae TIGR4	99.074	100	0.991
comGC/cglC	Streptococcus mitis SK321	94.444	100	0.944
comGC/cglC	Streptococcus mitis NCTC 12261	92.157	94.444	0.87
comYC	Streptococcus gordonii str. Challis substr. CH1	67.961	95.37	0.648
comYC	Streptococcus mutans UA140	62.745	94.444	0.593
comYC	Streptococcus mutans UA159	62.745	94.444	0.593
comYC	Streptococcus suis isolate S10	70.37	75	0.528
comGC	Lactococcus lactis subsp. cremoris KW2	53.922	94.444	0.509
comGC	Staphylococcus aureus MW2	50	79.63	0.398
comGC	Staphylococcus aureus N315	50	79.63	0.398
comGC	Latilactobacillus sakei subsp. sakei 23K	45.349	79.63	0.361