Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   QN329_RS01745 Genome accession   NZ_CP135103
Coordinates   312033..312512 (-) Length   159 a.a.
NCBI ID   WP_001204194.1    Uniprot ID   A0AAV3JNR5
Organism   Streptococcus agalactiae strain HU36/21     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 264776..311854 312033..312512 flank 179


Gene organization within MGE regions


Location: 264776..312512
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QN329_RS01395 (QN329_01395) - 264776..265351 (-) 576 WP_001231504.1 glycoside hydrolase family 73 protein -
  QN329_RS01400 (QN329_01400) - 265348..266100 (-) 753 WP_000739808.1 M15 family metallopeptidase -
  QN329_RS01405 (QN329_01405) - 266097..266789 (-) 693 WP_000049274.1 histidine phosphatase family protein -
  QN329_RS01410 (QN329_01410) - 267001..267184 (-) 184 Protein_254 Paratox -
  QN329_RS01415 (QN329_01415) - 267600..267770 (+) 171 WP_000356856.1 hypothetical protein -
  QN329_RS01420 (QN329_01420) - 267810..268010 (-) 201 WP_000076707.1 CsbD family protein -
  QN329_RS01425 (QN329_01425) - 268120..268419 (-) 300 WP_000258211.1 STAS-like domain-containing protein -
  QN329_RS01430 (QN329_01430) - 268492..269058 (-) 567 WP_410531494.1 hypothetical protein -
  QN329_RS01435 (QN329_01435) - 269444..270775 (-) 1332 WP_000257237.1 GH25 family lysozyme -
  QN329_RS01440 (QN329_01440) - 270901..271155 (-) 255 WP_000611524.1 phage holin -
  QN329_RS01445 (QN329_01445) - 271157..271459 (-) 303 WP_000215499.1 hypothetical protein -
  QN329_RS01450 (QN329_01450) - 271472..271684 (-) 213 WP_000698337.1 hypothetical protein -
  QN329_RS01455 (QN329_01455) - 271659..271985 (-) 327 WP_000404431.1 DUF1366 domain-containing protein -
  QN329_RS01460 (QN329_01460) - 271999..273989 (-) 1991 Protein_264 DUF859 family phage minor structural protein -
  QN329_RS01465 (QN329_01465) - 274002..278129 (-) 4128 WP_410531496.1 glucosaminidase domain-containing protein -
  QN329_RS01470 (QN329_01470) - 278120..279643 (-) 1524 WP_410531498.1 distal tail protein Dit -
  QN329_RS01475 (QN329_01475) - 279640..283580 (-) 3941 Protein_267 phage tail tape measure protein -
  QN329_RS01480 (QN329_01480) - 283593..283766 (-) 174 WP_000928086.1 hypothetical protein -
  QN329_RS01485 (QN329_01485) gpG 283774..284109 (-) 336 WP_410531500.1 phage tail assembly chaperone G -
  QN329_RS01490 (QN329_01490) - 284163..284675 (-) 513 WP_410531634.1 major tail protein -
  QN329_RS01495 (QN329_01495) - 284802..285227 (-) 426 WP_000559944.1 hypothetical protein -
  QN329_RS01500 (QN329_01500) - 285224..285601 (-) 378 WP_000160228.1 HK97-gp10 family putative phage morphogenesis protein -
  QN329_RS01505 (QN329_01505) - 285598..285945 (-) 348 WP_000632972.1 phage head closure protein -
  QN329_RS01510 (QN329_01510) - 285942..286244 (-) 303 WP_410531503.1 head-tail connector protein -
  QN329_RS01515 (QN329_01515) - 286247..286408 (-) 162 WP_017285214.1 hypothetical protein -
  QN329_RS01520 (QN329_01520) - 286422..287607 (-) 1186 Protein_276 phage major capsid protein -
  QN329_RS01525 (QN329_01525) - 287631..288296 (-) 666 WP_410531505.1 head maturation protease, ClpP-related -
  QN329_RS01530 (QN329_01530) - 288274..289494 (-) 1221 WP_000007732.1 phage portal protein -
  QN329_RS01535 (QN329_01535) - 289501..289731 (-) 231 WP_001042284.1 hypothetical protein -
  QN329_RS01540 (QN329_01540) - 289728..289895 (-) 168 WP_000578945.1 hypothetical protein -
  QN329_RS01545 (QN329_01545) - 289892..291646 (-) 1755 Protein_281 terminase large subunit -
  QN329_RS01550 (QN329_01550) - 291650..291880 (-) 231 WP_000805624.1 hypothetical protein -
  QN329_RS01555 (QN329_01555) - 291883..292350 (-) 468 WP_000532792.1 phage terminase small subunit P27 family -
  QN329_RS01560 (QN329_01560) - 292523..292858 (-) 336 WP_001247766.1 HNH endonuclease -
  QN329_RS01565 (QN329_01565) - 292956..293141 (+) 186 WP_001132272.1 type II toxin-antitoxin system HicA family toxin -
  QN329_RS01570 (QN329_01570) - 293194..293571 (+) 378 WP_410531507.1 type II toxin-antitoxin system HicB family antitoxin -
  QN329_RS01580 (QN329_01580) - 294338..294774 (-) 437 Protein_287 ArpU family phage packaging/lysis transcriptional regulator -
  QN329_RS01585 (QN329_01585) - 295166..295432 (-) 267 WP_000660741.1 hypothetical protein -
  QN329_RS01590 (QN329_01590) - 295429..295623 (-) 195 WP_000221696.1 hypothetical protein -
  QN329_RS01595 (QN329_01595) - 295811..296110 (-) 300 WP_410531509.1 hypothetical protein -
  QN329_RS01600 (QN329_01600) - 296130..296654 (-) 525 WP_001019155.1 DUF1642 domain-containing protein -
  QN329_RS01605 (QN329_01605) - 296651..296794 (-) 144 WP_410531511.1 hypothetical protein -
  QN329_RS01610 (QN329_01610) - 296918..297325 (-) 408 WP_000612386.1 YopX family protein -
  QN329_RS01615 (QN329_01615) - 297309..297596 (-) 288 WP_050198474.1 nucleotide modification associated domain-containing protein -
  QN329_RS01620 (QN329_01620) - 297608..297952 (-) 345 WP_410531513.1 hypothetical protein -
  QN329_RS01625 (QN329_01625) - 297933..298258 (-) 326 Protein_296 VRR-NUC domain-containing protein -
  QN329_RS01630 (QN329_01630) - 298501..300018 (-) 1518 WP_000564707.1 DNA primase family protein -
  QN329_RS01635 (QN329_01635) - 300011..300804 (-) 794 Protein_298 bifunctional DNA primase/polymerase -
  QN329_RS01640 (QN329_01640) - 300817..301278 (-) 462 WP_000494143.1 DUF669 domain-containing protein -
  QN329_RS01645 (QN329_01645) - 301294..302637 (-) 1344 WP_000776547.1 DEAD/DEAH box helicase -
  QN329_RS01650 (QN329_01650) - 302624..303316 (-) 693 WP_410531515.1 AAA family ATPase -
  QN329_RS01655 (QN329_01655) - 303303..303551 (-) 249 WP_228369508.1 hypothetical protein -
  QN329_RS01660 (QN329_01660) - 303864..304007 (-) 144 WP_000765382.1 hypothetical protein -
  QN329_RS01665 (QN329_01665) - 304037..304294 (-) 258 WP_001191791.1 hypothetical protein -
  QN329_RS01670 (QN329_01670) - 304373..304549 (-) 177 WP_000728090.1 helix-turn-helix domain-containing protein -
  QN329_RS01675 (QN329_01675) - 304664..304840 (+) 177 WP_017645150.1 hypothetical protein -
  QN329_RS01680 (QN329_01680) - 304868..305059 (-) 192 WP_001003168.1 hypothetical protein -
  QN329_RS01685 (QN329_01685) - 305078..305599 (-) 522 WP_410531517.1 hypothetical protein -
  QN329_RS01690 (QN329_01690) - 305592..306551 (-) 960 WP_001156317.1 hypothetical protein -
  QN329_RS01695 (QN329_01695) - 306605..306811 (-) 207 WP_410531518.1 helix-turn-helix transcriptional regulator -
  QN329_RS01700 (QN329_01700) - 306884..307063 (+) 180 WP_410531520.1 hypothetical protein -
  QN329_RS01705 (QN329_01705) - 307080..307340 (-) 261 WP_000356583.1 hypothetical protein -
  QN329_RS01710 (QN329_01710) - 307391..308033 (+) 643 Protein_313 hypothetical protein -
  QN329_RS01715 (QN329_01715) - 308131..308289 (-) 159 WP_001104146.1 hypothetical protein -
  QN329_RS01720 (QN329_01720) - 308348..308560 (+) 213 WP_047208985.1 hypothetical protein -
  QN329_RS01725 (QN329_01725) - 308549..308698 (-) 150 WP_017645151.1 hypothetical protein -
  QN329_RS01730 (QN329_01730) - 309058..309837 (+) 780 WP_000095652.1 S24 family peptidase -
  QN329_RS01735 (QN329_01735) - 309969..310514 (+) 546 WP_410531522.1 hypothetical protein -
  QN329_RS01740 (QN329_01740) - 310757..311854 (+) 1098 WP_161512418.1 site-specific integrase -
  QN329_RS01745 (QN329_01745) comX/sigX 312033..312512 (-) 480 WP_001204194.1 sigma-70 family RNA polymerase sigma factor Regulator

Sequence

Protein


Download         Length: 159 a.a.        Molecular weight: 19447.28 Da        Isoelectric Point: 6.2639

>NTDB_id=885363 QN329_RS01745 WP_001204194.1 312033..312512(-) (comX/sigX) [Streptococcus agalactiae strain HU36/21]
MRDFEELFDKVKPIVMKLRRNYFVQLWEYDDWIQEGRIVLFRLLEEHPYLLDNESKLFIYFKTKFSNYLNDVLRHQDCQK
RQFNKMPYEEISEVSHYVKSKGLVLDDYIAYRDTLTKVEETLSDIDKEKFEKLISGERFAGKKQFIRDIQPFFNAFKAD

Nucleotide


Download         Length: 480 bp        

>NTDB_id=885363 QN329_RS01745 WP_001204194.1 312033..312512(-) (comX/sigX) [Streptococcus agalactiae strain HU36/21]
TTGAGAGATTTTGAGGAGTTGTTTGATAAAGTAAAGCCAATCGTAATGAAGCTGAGAAGAAATTATTTTGTTCAACTTTG
GGAATATGATGATTGGATTCAAGAAGGACGTATTGTACTTTTTAGGTTGCTTGAAGAGCATCCGTATTTATTGGATAATG
AAAGCAAACTATTCATTTACTTTAAAACAAAATTTTCAAATTATTTAAACGATGTATTAAGACACCAAGATTGTCAAAAG
CGACAATTTAATAAAATGCCTTATGAAGAAATCAGTGAAGTTAGTCACTATGTTAAGAGTAAAGGACTAGTTTTAGATGA
CTATATTGCTTATCGTGATACTTTAACAAAAGTGGAAGAAACTTTGTCAGATATTGATAAAGAAAAATTTGAAAAACTGA
TTAGTGGTGAACGTTTTGCGGGGAAGAAACAATTCATACGAGATATTCAACCTTTTTTCAATGCTTTTAAAGCGGATTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

56.688

98.742

0.56
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

52.349

93.711

0.491
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

52.349

93.711

0.491
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

52

94.34

0.491
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

52

94.34

0.491
  comX/sigX Streptococcus mutans UA159

49.677

97.484

0.484
  comX Streptococcus sobrinus strain NIDR 6715-7

43.59

98.113

0.428
  comX/sigX Streptococcus suis D9

43.226

97.484

0.421
  comX/sigX Streptococcus suis isolate S10

43.226

97.484

0.421
  comX/sigX Streptococcus suis P1/7

43.226

97.484

0.421
  comX Streptococcus thermophilus LMD-9

42.177

92.453

0.39
  comX Streptococcus thermophilus LMG 18311

42.177

92.453

0.39
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

39.869

96.226

0.384
  comX/comX2 Streptococcus pneumoniae Rx1

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae Rx1

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae D39

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae D39

40.397

94.969

0.384
  comX/comX2 Streptococcus pneumoniae R6

40.397

94.969

0.384
  comX/comX1 Streptococcus pneumoniae R6

40.397

94.969

0.384
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

39.216

96.226

0.377
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

39.216

96.226

0.377
  comX Streptococcus salivarius SK126

40.816

92.453

0.377
  comX/sigX Streptococcus salivarius strain HSISS4

40.816

92.453

0.377
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

38.562

96.226

0.371