Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   NLY77_RS00080 Genome accession   NZ_CP100431
Coordinates   15966..16436 (+) Length   156 a.a.
NCBI ID   WP_002936602.1    Uniprot ID   A0A075SE61
Organism   Streptococcus suis strain 1521251     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 13658..56146 15966..16436 within 0


Gene organization within MGE regions


Location: 13658..56146
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NLY77_RS00075 (NLY77_00075) ftsH 13658..15628 (+) 1971 WP_024394590.1 ATP-dependent zinc metalloprotease FtsH -
  NLY77_RS00080 (NLY77_00080) comX/sigX 15966..16436 (+) 471 WP_002936602.1 sigma-70 family RNA polymerase sigma factor Regulator
  NLY77_RS00185 (NLY77_00185) mreC 23692..24528 (+) 837 WP_024394836.1 rod shape-determining protein MreC -
  NLY77_RS00190 (NLY77_00190) mreD 24530..25033 (+) 504 WP_228475524.1 rod shape-determining protein MreD -
  NLY77_RS00195 (NLY77_00195) pcsB 25118..26374 (+) 1257 WP_024394838.1 peptidoglycan hydrolase PcsB -
  NLY77_RS00200 (NLY77_00200) - 26477..27445 (+) 969 WP_002935337.1 ribose-phosphate diphosphokinase -
  NLY77_RS00205 (NLY77_00205) - 27532..28710 (+) 1179 WP_024394839.1 pyridoxal phosphate-dependent aminotransferase -
  NLY77_RS00210 (NLY77_00210) recO 28697..29479 (+) 783 WP_024394840.1 DNA repair protein RecO -
  NLY77_RS00215 (NLY77_00215) plsX 29476..30483 (+) 1008 WP_014637253.1 phosphate acyltransferase PlsX -
  NLY77_RS00220 (NLY77_00220) - 30476..30724 (+) 249 WP_014637254.1 phosphopantetheine-binding protein -
  NLY77_RS00225 (NLY77_00225) purC 30842..31549 (+) 708 WP_024394841.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  NLY77_RS00230 (NLY77_00230) - 31562..35281 (+) 3720 WP_044675272.1 phosphoribosylformylglycinamidine synthase -
  NLY77_RS00235 (NLY77_00235) purF 35284..36738 (+) 1455 WP_024394843.1 amidophosphoribosyltransferase -
  NLY77_RS00240 (NLY77_00240) purM 36794..37816 (+) 1023 WP_024394844.1 phosphoribosylformylglycinamidine cyclo-ligase -
  NLY77_RS00245 (NLY77_00245) purN 37813..38364 (+) 552 WP_024386485.1 phosphoribosylglycinamide formyltransferase -
  NLY77_RS00250 (NLY77_00250) purH 38374..39921 (+) 1548 WP_024394845.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  NLY77_RS00255 (NLY77_00255) - 39986..40816 (+) 831 WP_002935322.1 DNA adenine methylase -
  NLY77_RS00260 (NLY77_00260) - 40806..41621 (+) 816 WP_032499218.1 site-specific DNA-methyltransferase -
  NLY77_RS00265 (NLY77_00265) - 41599..42525 (+) 927 WP_002935320.1 type II restriction endonuclease -
  NLY77_RS00270 (NLY77_00270) - 42525..43430 (+) 906 WP_002935319.1 type II restriction endonuclease -
  NLY77_RS00275 (NLY77_00275) purD 43551..44813 (+) 1263 WP_002935318.1 phosphoribosylamine--glycine ligase -
  NLY77_RS00280 (NLY77_00280) purE 44839..45327 (+) 489 WP_002935317.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  NLY77_RS00285 (NLY77_00285) purK 45314..46399 (+) 1086 WP_002935314.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  NLY77_RS00290 (NLY77_00290) - 46386..47309 (+) 924 WP_002935313.1 DUF4268 domain-containing protein -
  NLY77_RS00295 (NLY77_00295) purB 47344..48636 (+) 1293 WP_013730055.1 adenylosuccinate lyase -
  NLY77_RS00300 (NLY77_00300) - 49145..49969 (+) 825 WP_002935311.1 ABC transporter ATP-binding protein -
  NLY77_RS00305 (NLY77_00305) - 49962..50696 (+) 735 WP_002935310.1 ABC transporter permease -
  NLY77_RS00310 (NLY77_00310) - 51031..51759 (+) 729 WP_002935309.1 hypothetical protein -
  NLY77_RS00315 (NLY77_00315) - 51769..52347 (+) 579 WP_002935308.1 CPBP family intramembrane glutamic endopeptidase -
  NLY77_RS00320 (NLY77_00320) - 52362..52790 (+) 429 WP_002935307.1 Msa family membrane protein -
  NLY77_RS00325 (NLY77_00325) - 52783..53655 (+) 873 WP_002935305.1 ABC transporter ATP-binding protein -
  NLY77_RS00330 (NLY77_00330) - 53661..54431 (+) 771 WP_002935304.1 membrane protein -
  NLY77_RS00335 (NLY77_00335) - 54434..56146 (+) 1713 WP_002935303.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 156 a.a.        Molecular weight: 19072.97 Da        Isoelectric Point: 8.9339

>NTDB_id=705232 NLY77_RS00080 WP_002936602.1 15966..16436(+) (comX/sigX) [Streptococcus suis strain 1521251]
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKR
KFDRMPHEDIHELSHAIQSPGLINDELLMLRGALRDYRKNLSNDQLDKYEKLISGQCFNGRREMIRDLQIHLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=705232 NLY77_RS00080 WP_002936602.1 15966..16436(+) (comX/sigX) [Streptococcus suis strain 1521251]
ATGGAATTCGAAAAAGTGTACGCAAGCGTCAAAGGTATTGTAAATAAGGCTCGAAAAGAGTTTTACATTAAACTATGGGA
TCGAGATGATTGGGAACAAGAAGGAATGATGACCTTGTTTGAATTATTAGAAGCTCAACCGTGGCTAGTTGATGAACAAG
TTCAATTATATTGTTATTTTAAAGTTAAGTTCAGAAATCGAATCAAGGATCGTATCCGCAAACAGGAAAGTCAAAAACGC
AAGTTTGACCGTATGCCACATGAAGATATTCACGAATTATCTCACGCAATACAATCACCGGGATTAATAAACGATGAACT
ATTAATGCTAAGAGGTGCCTTGAGAGATTATCGAAAAAATCTGAGTAATGATCAACTTGATAAATACGAAAAATTAATTA
GCGGACAATGTTTTAATGGTCGCCGTGAAATGATACGTGATTTACAAATTCATTTGAAAGACTTTCGCTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A075SE61

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

100

100

1
  comX/sigX Streptococcus suis isolate S10

99.359

100

0.994
  comX/sigX Streptococcus suis P1/7

99.359

100

0.994
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487
  comX/comX1 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449
  comX/comX2 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

45.752

98.077

0.449
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/comX1 Streptococcus pneumoniae Rx1

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae D39

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae D39

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae R6

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae R6

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae Rx1

45.695

96.795

0.442
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

44.444

98.077

0.436
  comX/sigX Streptococcus mutans UA159

43.226

99.359

0.429
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX Streptococcus sobrinus strain NIDR 6715-7

40.523

98.077

0.397
  comX Streptococcus thermophilus LMG 18311

40.523

98.077

0.397
  comX Streptococcus thermophilus LMD-9

40.523

98.077

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.854

100

0.391
  comX Streptococcus salivarius SK126

39.869

98.077

0.391
  comX/sigX Streptococcus salivarius strain HSISS4

39.869

98.077

0.391