Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   NLY76_RS00565 Genome accession   NZ_CP100430
Coordinates   88052..88522 (+) Length   156 a.a.
NCBI ID   WP_044667396.1    Uniprot ID   A0A123SPK4
Organism   Streptococcus suis strain LSS42     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 88052..102315 88052..88522 within 0
IScluster/Tn 86897..87749 88052..88522 flank 303


Gene organization within MGE regions


Location: 86897..102315
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NLY76_RS00560 (NLY76_00560) - 86897..87749 (+) 853 Protein_90 IS982 family transposase -
  NLY76_RS00565 (NLY76_00565) comX/sigX 88052..88522 (+) 471 WP_044667396.1 sigma-70 family RNA polymerase sigma factor Regulator
  NLY76_RS00650 (NLY76_00650) - 95184..95966 (+) 783 WP_044677626.1 DUF2971 domain-containing protein -
  NLY76_RS00655 (NLY76_00655) - 95963..96502 (-) 540 Protein_93 site-specific integrase -
  NLY76_RS00660 (NLY76_00660) - 96711..97154 (+) 444 WP_004195554.1 zinc-dependent MarR family transcriptional regulator -
  NLY76_RS00665 (NLY76_00665) - 97155..97859 (+) 705 WP_002936595.1 metal ABC transporter ATP-binding protein -
  NLY76_RS00670 (NLY76_00670) - 97852..98664 (+) 813 WP_002936593.1 metal ABC transporter permease -
  NLY76_RS00675 (NLY76_00675) - 98674..100185 (+) 1512 WP_014637298.1 zinc ABC transporter substrate-binding protein AdcA -
  NLY76_RS00680 (NLY76_00680) - 100288..100758 (+) 471 WP_044685594.1 CopY/TcrY family copper transport repressor -
  NLY76_RS00685 (NLY76_00685) - 100939..101148 (+) 210 WP_014637302.1 heavy-metal-associated domain-containing protein -
  NLY76_RS00690 (NLY76_00690) - 101385..101752 (-) 368 Protein_100 HIT family protein -
  NLY76_RS00695 (NLY76_00695) - 101764..102315 (-) 552 WP_044770152.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 156 a.a.        Molecular weight: 19087.00 Da        Isoelectric Point: 8.9339

>NTDB_id=705185 NLY76_RS00565 WP_044667396.1 88052..88522(+) (comX/sigX) [Streptococcus suis strain LSS42]
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKR
KFDRMPHEDIHELSHAIQSPGLINDELLMLRGALRDYRKNLTNDQLDKYEKLISGQCFNGRREMIRDLQIHLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=705185 NLY76_RS00565 WP_044667396.1 88052..88522(+) (comX/sigX) [Streptococcus suis strain LSS42]
ATGGAATTCGAAAAAGTGTACGCAAGCGTCAAAGGTATTGTAAACAAGGCTCGAAAAGAGTTTTACATTAAACTATGGGA
TCGAGATGATTGGGAACAAGAAGGAATGATGACCTTGTTTGAATTGTTGGAAGCTCAACCGTGGCTAGTTGATGAACAAG
TTCAATTATATTGTTATTTTAAAGTTAAGTTCAGAAATCGAATCAAGGATCGTATCCGCAAACAGGAAAGTCAAAAACGC
AAGTTTGACCGTATGCCACATGAAGATATTCACGAATTATCTCACGCAATACAATCACCGGGATTAATAAACGATGAACT
ATTAATGCTAAGAGGTGCCTTGAGAGATTATCGAAAAAATCTGACTAATGATCAACTTGATAAATACGAAAAATTAATTA
GCGGACAATGTTTTAATGGTCGCCGTGAAATGATACGTGATTTACAAATTCATTTGAAAGACTTTCGCTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A123SPK4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

99.359

100

0.994
  comX/sigX Streptococcus suis isolate S10

98.718

100

0.987
  comX/sigX Streptococcus suis P1/7

98.718

100

0.987
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

48.387

99.359

0.481
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

48.387

99.359

0.481
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

45.098

98.077

0.442
  comX/comX1 Streptococcus pneumoniae TIGR4

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae TIGR4

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae R6

45.033

96.795

0.436
  comX/comX2 Streptococcus pneumoniae Rx1

45.033

96.795

0.436
  comX/comX1 Streptococcus pneumoniae Rx1

45.033

96.795

0.436
  comX/comX2 Streptococcus pneumoniae D39

45.033

96.795

0.436
  comX/comX1 Streptococcus pneumoniae D39

45.033

96.795

0.436
  comX/comX2 Streptococcus pneumoniae R6

45.033

96.795

0.436
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

44.444

98.077

0.436
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

44.444

98.077

0.436
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

43.791

98.077

0.429
  comX/sigX Streptococcus mutans UA159

42.581

99.359

0.423
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX Streptococcus sobrinus strain NIDR 6715-7

40.523

98.077

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.854

100

0.391
  comX Streptococcus thermophilus LMG 18311

39.869

98.077

0.391
  comX Streptococcus thermophilus LMD-9

39.869

98.077

0.391
  comX Streptococcus salivarius SK126

39.216

98.077

0.385
  comX/sigX Streptococcus salivarius strain HSISS4

39.216

98.077

0.385