Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   MUY23_RS10395 Genome accession   NZ_CP095162
Coordinates   2129932..2130402 (-) Length   156 a.a.
NCBI ID   WP_002936602.1    Uniprot ID   A0A075SE61
Organism   Streptococcus suis strain TJS75     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2104701..2132852 2129932..2130402 within 0
IScluster/Tn 2130609..2132852 2129932..2130402 flank 207


Gene organization within MGE regions


Location: 2104701..2132852
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MUY23_RS10215 - 2104701..2105516 (-) 816 WP_032499218.1 site-specific DNA-methyltransferase -
  MUY23_RS10220 - 2105506..2106336 (-) 831 WP_002935322.1 DNA adenine methylase -
  MUY23_RS10225 purH 2106401..2107948 (-) 1548 WP_002935323.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  MUY23_RS10230 purN 2107958..2108509 (-) 552 WP_002935324.1 phosphoribosylglycinamide formyltransferase -
  MUY23_RS10235 purM 2108506..2109528 (-) 1023 WP_002935325.1 phosphoribosylformylglycinamidine cyclo-ligase -
  MUY23_RS10240 purF 2109584..2111038 (-) 1455 WP_002935326.1 amidophosphoribosyltransferase -
  MUY23_RS10245 - 2111041..2114760 (-) 3720 WP_002935327.1 phosphoribosylformylglycinamidine synthase -
  MUY23_RS10250 purC 2114773..2115480 (-) 708 WP_002935328.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  MUY23_RS10255 - 2115598..2115846 (-) 249 WP_002935333.1 phosphopantetheine-binding protein -
  MUY23_RS10260 plsX 2115839..2116846 (-) 1008 WP_002935334.1 phosphate acyltransferase PlsX -
  MUY23_RS10265 recO 2116843..2117625 (-) 783 WP_002935335.1 DNA repair protein RecO -
  MUY23_RS10270 - 2117612..2118790 (-) 1179 WP_002935336.1 pyridoxal phosphate-dependent aminotransferase -
  MUY23_RS10275 - 2118877..2119845 (-) 969 WP_002935337.1 ribose-phosphate diphosphokinase -
  MUY23_RS10280 - 2119948..2121204 (-) 1257 WP_002935338.1 CHAP domain-containing protein -
  MUY23_RS10285 mreD 2121289..2121804 (-) 516 WP_002935339.1 rod shape-determining protein MreD -
  MUY23_RS10290 mreC 2121794..2122630 (-) 837 WP_002935340.1 rod shape-determining protein MreC -
  MUY23_RS10395 comX/sigX 2129932..2130402 (-) 471 WP_002936602.1 sigma-70 family RNA polymerase sigma factor Regulator
  MUY23_RS10400 - 2130609..2131464 (-) 856 Protein_2029 IS982 family transposase -
  MUY23_RS10405 - 2131596..2132852 (-) 1257 WP_002936184.1 ISL3-like element ISSsu6 family transposase -

Sequence

Protein


Download         Length: 156 a.a.        Molecular weight: 19072.97 Da        Isoelectric Point: 8.9339

>NTDB_id=675856 MUY23_RS10395 WP_002936602.1 2129932..2130402(-) (comX/sigX) [Streptococcus suis strain TJS75]
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKR
KFDRMPHEDIHELSHAIQSPGLINDELLMLRGALRDYRKNLSNDQLDKYEKLISGQCFNGRREMIRDLQIHLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=675856 MUY23_RS10395 WP_002936602.1 2129932..2130402(-) (comX/sigX) [Streptococcus suis strain TJS75]
ATGGAATTCGAAAAAGTGTACGCAAGCGTCAAAGGTATTGTAAATAAGGCTCGAAAAGAGTTTTACATTAAACTATGGGA
TCGAGATGATTGGGAACAAGAAGGAATGATGACCTTGTTTGAATTGTTGGAAGCTCAACCGTGGCTAGTTGATGAACAAG
TTCAATTATATTGTTATTTTAAAGTCAAGTTCAGAAATCGAATCAAGGATCGTATCCGCAAACAGGAAAGTCAAAAACGC
AAGTTTGACCGTATGCCACATGAAGATATTCACGAATTATCTCACGCAATACAATCACCGGGATTAATAAACGATGAACT
ATTAATGCTAAGAGGTGCCTTGAGAGATTATCGAAAAAATCTGAGTAATGATCAACTTGATAAATACGAAAAATTAATTA
GCGGACAATGTTTTAATGGTCGCCGTGAAATGATACGTGATTTACAAATTCATTTGAAAGACTTTCGCTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A075SE61

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

100

100

1
  comX/sigX Streptococcus suis isolate S10

99.359

100

0.994
  comX/sigX Streptococcus suis P1/7

99.359

100

0.994
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487
  comX/comX1 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449
  comX/comX2 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

45.752

98.077

0.449
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/comX1 Streptococcus pneumoniae Rx1

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae D39

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae D39

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae R6

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae R6

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae Rx1

45.695

96.795

0.442
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

44.444

98.077

0.436
  comX/sigX Streptococcus mutans UA159

43.226

99.359

0.429
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX Streptococcus sobrinus strain NIDR 6715-7

40.523

98.077

0.397
  comX Streptococcus thermophilus LMG 18311

40.523

98.077

0.397
  comX Streptococcus thermophilus LMD-9

40.523

98.077

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.854

100

0.391
  comX Streptococcus salivarius SK126

39.869

98.077

0.391
  comX/sigX Streptococcus salivarius strain HSISS4

39.869

98.077

0.391