Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR/comR2   Type   Regulator
Locus tag   SCRE_RS08845 Genome accession   NC_022236
Coordinates   1775412..1775894 (-) Length   160 a.a.
NCBI ID   WP_006267672.1    Uniprot ID   A0A380L5Q1
Organism   Streptococcus constellatus subsp. pharyngis C232     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1762914..1775894 1775412..1775894 within 0


Gene organization within MGE regions


Location: 1762914..1775894
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCRE_RS08725 (SCRE_1711) - 1762914..1763621 (+) 708 WP_020998079.1 hypothetical protein -
  SCRE_RS08730 (SCRE_1712) - 1763632..1764957 (+) 1326 WP_020998080.1 type IV secretory system conjugative DNA transfer family protein -
  SCRE_RS08735 (SCRE_1713) - 1765047..1765361 (+) 315 WP_006268020.1 hypothetical protein -
  SCRE_RS08740 (SCRE_1714) - 1765395..1765784 (+) 390 WP_006268423.1 hypothetical protein -
  SCRE_RS08745 (SCRE_1715) - 1765801..1766532 (+) 732 WP_020998081.1 metallophosphoesterase -
  SCRE_RS08750 (SCRE_1716) - 1766709..1767491 (+) 783 WP_020998082.1 phasyl DNA replicon protein -
  SCRE_RS08755 (SCRE_1717) - 1767505..1767711 (+) 207 WP_006268084.1 DUF3173 domain-containing protein -
  SCRE_RS08760 (SCRE_1718) - 1767701..1768786 (+) 1086 WP_006268469.1 tyrosine-type recombinase/integrase -
  SCRE_RS08845 (SCRE_1735) comR/comR2 1775412..1775894 (-) 483 WP_006267672.1 sigma-70 family RNA polymerase sigma factor Regulator

Sequence

Protein


Download         Length: 160 a.a.        Molecular weight: 19855.70 Da        Isoelectric Point: 7.9710

>NTDB_id=61497 SCRE_RS08845 WP_006267672.1 1775412..1775894(-) (comR/comR2) [Streptococcus constellatus subsp. pharyngis C232]
MDFKELYDKVRGIVLKCRREYYVHLWELSDWDQEGMLVLYELVSRYPQLVESESRLYVYYKTKFRNHIKDILRKQESQKR
KLDRQVYEEVSEIGHKLSLKELYLDELVILRDQLKSYQKQLSPEKQEQYERLLADERFQGRQAMLRELRTYLQDYDERKS

Nucleotide


Download         Length: 483 bp        

>NTDB_id=61497 SCRE_RS08845 WP_006267672.1 1775412..1775894(-) (comR/comR2) [Streptococcus constellatus subsp. pharyngis C232]
ATGGACTTCAAGGAATTGTATGACAAAGTGAGAGGGATCGTACTGAAGTGTCGCCGGGAATATTATGTCCACCTGTGGGA
GTTAAGTGATTGGGACCAAGAAGGGATGCTGGTCTTATATGAGTTGGTGAGTCGCTATCCGCAACTGGTAGAGTCAGAAA
GTCGTCTCTATGTTTACTATAAGACCAAGTTCCGTAATCACATCAAGGACATCCTGCGCAAACAAGAAAGCCAAAAGCGC
AAACTAGACCGTCAAGTCTATGAGGAAGTGAGCGAGATAGGTCACAAGCTCAGCCTGAAAGAACTCTATTTGGATGAATT
GGTGATTCTCCGAGACCAACTAAAGAGCTATCAAAAACAGCTAAGTCCAGAGAAACAAGAACAGTATGAGCGCTTACTAG
CAGATGAACGGTTTCAAGGACGCCAAGCGATGCTTCGGGAGTTACGGACCTACTTACAAGATTACGATGAAAGAAAAAGC
TAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380L5Q1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

61.392

98.75

0.606
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

61.392

98.75

0.606
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

56.41

97.5

0.55
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

55.128

97.5

0.537
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

55.128

97.5

0.537
  comX/comX1 Streptococcus pneumoniae R6

55.556

95.625

0.531
  comX/comX1 Streptococcus pneumoniae D39

55.556

95.625

0.531
  comX/comX2 Streptococcus pneumoniae Rx1

55.556

95.625

0.531
  comX/comX1 Streptococcus pneumoniae Rx1

55.556

95.625

0.531
  comX/comX2 Streptococcus pneumoniae D39

55.556

95.625

0.531
  comX/comX2 Streptococcus pneumoniae R6

55.556

95.625

0.531
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

54.487

97.5

0.531
  comX/comX2 Streptococcus pneumoniae TIGR4

54.902

95.625

0.525
  comX/comX1 Streptococcus pneumoniae TIGR4

54.902

95.625

0.525
  comX/sigX Streptococcus mutans UA159

50.318

98.125

0.494
  comX/sigX Streptococcus suis D9

46.452

96.875

0.45
  comX/sigX Streptococcus suis isolate S10

46.452

96.875

0.45
  comX/sigX Streptococcus suis P1/7

46.452

96.875

0.45
  comX Streptococcus salivarius SK126

43.506

96.25

0.419
  comX/sigX Streptococcus salivarius strain HSISS4

42.857

96.25

0.412
  comX Streptococcus thermophilus LMG 18311

42.857

96.25

0.412
  comX Streptococcus thermophilus LMD-9

42.857

96.25

0.412
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40.764

98.125

0.4
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40.764

98.125

0.4
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.764

98.125

0.4
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.764

98.125

0.4
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40.764

98.125

0.4
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40.764

98.125

0.4
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

39.744

97.5

0.388
  comX Streptococcus sobrinus strain NIDR 6715-7

37.419

96.875

0.362

Multiple sequence alignment