Detailed information    

insolico Bioinformatically predicted

Overview


Name   comX/sigX   Type   Regulator
Locus tag   JZ789_RS00075 Genome accession   NZ_CP071806
Coordinates   15952..16422 (+) Length   156 a.a.
NCBI ID   WP_002936602.1    Uniprot ID   A0A075SE61
Organism   Streptococcus suis strain GX69     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 13656..44175 15952..16422 within 0


Gene organization within MGE regions


Location: 13656..44175
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JZ789_RS00070 (JZ789_00070) ftsH 13656..15626 (+) 1971 WP_004194314.1 ATP-dependent zinc metalloprotease FtsH -
  JZ789_RS00075 (JZ789_00075) comX/sigX 15952..16422 (+) 471 WP_002936602.1 sigma-70 family RNA polymerase sigma factor Regulator
  JZ789_RS00180 (JZ789_00180) mreC 23812..24648 (+) 837 WP_024417842.1 rod shape-determining protein MreC -
  JZ789_RS00185 (JZ789_00185) mreD 24665..25153 (+) 489 WP_009908846.1 rod shape-determining protein MreD -
  JZ789_RS00190 (JZ789_00190) pcsB 25238..26494 (+) 1257 WP_002935338.1 peptidoglycan hydrolase PcsB -
  JZ789_RS00195 (JZ789_00195) - 26597..27565 (+) 969 WP_002935337.1 ribose-phosphate diphosphokinase -
  JZ789_RS00200 (JZ789_00200) - 27652..28830 (+) 1179 WP_002935336.1 pyridoxal phosphate-dependent aminotransferase -
  JZ789_RS00205 (JZ789_00205) recO 28817..29599 (+) 783 WP_002935335.1 DNA repair protein RecO -
  JZ789_RS00210 (JZ789_00210) plsX 29596..30603 (+) 1008 WP_002935334.1 phosphate acyltransferase PlsX -
  JZ789_RS00215 (JZ789_00215) - 30596..30844 (+) 249 WP_002935333.1 phosphopantetheine-binding protein -
  JZ789_RS00220 (JZ789_00220) purC 30962..31669 (+) 708 WP_002935328.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  JZ789_RS00225 (JZ789_00225) - 31682..35401 (+) 3720 WP_002935327.1 phosphoribosylformylglycinamidine synthase -
  JZ789_RS00230 (JZ789_00230) purF 35404..36858 (+) 1455 WP_002935326.1 amidophosphoribosyltransferase -
  JZ789_RS00235 (JZ789_00235) purM 36914..37936 (+) 1023 WP_009908859.1 phosphoribosylformylglycinamidine cyclo-ligase -
  JZ789_RS00240 (JZ789_00240) purN 37933..38484 (+) 552 WP_009908860.1 phosphoribosylglycinamide formyltransferase -
  JZ789_RS00245 (JZ789_00245) purH 38494..40041 (+) 1548 WP_174846764.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  JZ789_RS00250 (JZ789_00250) - 40106..40936 (+) 831 WP_002935322.1 DNA adenine methylase -
  JZ789_RS00255 (JZ789_00255) - 40926..41741 (+) 816 WP_032499218.1 site-specific DNA-methyltransferase -
  JZ789_RS00260 (JZ789_00260) - 41719..42417 (+) 699 WP_226315416.1 type II restriction endonuclease -
  JZ789_RS00265 (JZ789_00265) ltrA 42502..44175 (-) 1674 WP_044680551.1 group II intron reverse transcriptase/maturase -

Sequence


Protein


Download         Length: 156 a.a.        Molecular weight: 19072.97 Da        Isoelectric Point: 8.9339

>NTDB_id=547928 JZ789_RS00075 WP_002936602.1 15952..16422(+) (comX/sigX) [Streptococcus suis strain GX69]
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKR
KFDRMPHEDIHELSHAIQSPGLINDELLMLRGALRDYRKNLSNDQLDKYEKLISGQCFNGRREMIRDLQIHLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=547928 JZ789_RS00075 WP_002936602.1 15952..16422(+) (comX/sigX) [Streptococcus suis strain GX69]
ATGGAATTCGAAAAAGTGTACGCAAGCGTCAAAGGTATTGTAAATAAGGCTCGAAAAGAGTTTTACATTAAACTATGGGA
TCGAGATGATTGGGAACAAGAAGGAATGATGACCTTGTTTGAATTGTTGGAAGCTCAACCGTGGCTAGTTGATGAACAAG
TTCAATTATATTGTTATTTTAAAGTCAAGTTCAGAAATCGAATCAAGGATCGTATCCGCAAACAGGAAAGTCAAAAACGC
AAGTTTGACCGTATGCCACATGAAGATATTCACGAATTATCTCACGCAATACAATCACCGGGATTAATAAACGATGAACT
ATTAATGCTAAGAGGTGCCTTGAGAGATTATCGAAAAAATCTGAGTAATGATCAACTTGATAAATACGAAAAATTAATTA
GCGGACAATGTTTTAATGGTCGCCGTGAAATGATACGTGATTTACAAATTCATTTGAAAGACTTTCGCTAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A075SE61

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

100

100

1

  comX/sigX Streptococcus suis isolate S10

99.359

100

0.994

  comX/sigX Streptococcus suis P1/7

99.359

100

0.994

  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487

  comX/comX1 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449

  comX/comX2 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

45.752

98.077

0.449

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

45.098

98.077

0.442

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

45.098

98.077

0.442

  comX/comX1 Streptococcus pneumoniae Rx1

45.695

96.795

0.442

  comX/comX2 Streptococcus pneumoniae D39

45.695

96.795

0.442

  comX/comX1 Streptococcus pneumoniae D39

45.695

96.795

0.442

  comX/comX2 Streptococcus pneumoniae R6

45.695

96.795

0.442

  comX/comX1 Streptococcus pneumoniae R6

45.695

96.795

0.442

  comX/comX2 Streptococcus pneumoniae Rx1

45.695

96.795

0.442

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

44.444

98.077

0.436

  comX/sigX Streptococcus mutans UA159

43.226

99.359

0.429

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.645

99.359

0.404

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.645

99.359

0.404

  comX Streptococcus sobrinus strain NIDR 6715-7

40.523

98.077

0.397

  comX Streptococcus thermophilus LMG 18311

40.523

98.077

0.397

  comX Streptococcus thermophilus LMD-9

40.523

98.077

0.397

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

99.359

0.397

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

99.359

0.397

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

99.359

0.397

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

99.359

0.397

  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.854

100

0.391

  comX Streptococcus salivarius SK126

39.869

98.077

0.391

  comX/sigX Streptococcus salivarius strain HSISS4

39.869

98.077

0.391