Detailed information    

insolico Bioinformatically predicted

Overview


Name   comR/comR2   Type   Regulator
Locus tag   I6J38_RS07535 Genome accession   NZ_CP069558
Coordinates   1515718..1516200 (+) Length   160 a.a.
NCBI ID   WP_006267672.1    Uniprot ID   A0A380L5Q1
Organism   Streptococcus constellatus strain FDAARGOS_1208     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1495366..1516200 1515718..1516200 within 0


Gene organization within MGE regions


Location: 1495366..1516200
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J38_RS07420 (I6J38_07420) - 1495366..1495965 (+) 600 WP_037592818.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
  I6J38_RS07425 (I6J38_07425) - 1495962..1496816 (+) 855 WP_006268819.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
  I6J38_RS07430 (I6J38_07430) - 1496929..1498260 (-) 1332 WP_022525745.1 relaxase/mobilization nuclease domain-containing protein -
  I6J38_RS07435 (I6J38_07435) - 1498266..1498616 (-) 351 WP_022525744.1 plasmid mobilization protein -
  I6J38_RS07440 (I6J38_07440) - 1498982..1499158 (+) 177 WP_004633836.1 subtilosin A family bacteriocin -
  I6J38_RS07445 (I6J38_07445) - 1499260..1500597 (+) 1338 WP_022525761.1 radical SAM protein -
  I6J38_RS07450 (I6J38_07450) - 1500624..1500776 (+) 153 WP_004633833.1 hypothetical protein -
  I6J38_RS07455 (I6J38_07455) - 1500779..1501483 (+) 705 WP_004633842.1 ATP-binding cassette domain-containing protein -
  I6J38_RS07460 (I6J38_07460) - 1501489..1502604 (+) 1116 WP_204116058.1 hypothetical protein -
  I6J38_RS07465 (I6J38_07465) - 1502723..1502917 (+) 195 WP_004633838.1 helix-turn-helix transcriptional regulator -
  I6J38_RS07470 (I6J38_07470) - 1503146..1503322 (+) 177 WP_004633836.1 subtilosin A family bacteriocin -
  I6J38_RS07475 (I6J38_07475) - 1503424..1504761 (+) 1338 WP_022525761.1 radical SAM protein -
  I6J38_RS07480 (I6J38_07480) - 1504788..1504940 (+) 153 WP_004633833.1 hypothetical protein -
  I6J38_RS07485 (I6J38_07485) - 1504960..1505955 (+) 996 WP_021003055.1 hypothetical protein -
  I6J38_RS07490 (I6J38_07490) - 1505957..1506817 (+) 861 WP_004633827.1 hypothetical protein -
  I6J38_RS07495 (I6J38_07495) - 1506792..1507487 (+) 696 WP_004633825.1 hypothetical protein -
  I6J38_RS07500 (I6J38_07500) - 1507755..1508165 (+) 411 WP_006267676.1 sigma-70 family RNA polymerase sigma factor -
  I6J38_RS07505 (I6J38_07505) - 1508630..1508860 (+) 231 WP_006267671.1 DUF6870 family protein -
  I6J38_RS07510 (I6J38_07510) - 1509002..1510672 (+) 1671 WP_006267670.1 recombinase family protein -
  I6J38_RS07515 (I6J38_07515) - 1510673..1512355 (+) 1683 WP_022525752.1 recombinase family protein -
  I6J38_RS07520 (I6J38_07520) - 1512357..1513901 (+) 1545 WP_006267678.1 recombinase family protein -
  I6J38_RS07525 (I6J38_07525) - 1513894..1514931 (+) 1038 WP_006267669.1 ORF6N domain-containing protein -
  I6J38_RS07530 (I6J38_07530) rplQ 1515119..1515286 (+) 168 Protein_1482 50S ribosomal protein L17 -
  I6J38_RS07535 (I6J38_07535) comR/comR2 1515718..1516200 (+) 483 WP_006267672.1 sigma-70 family RNA polymerase sigma factor Regulator

Sequence


Protein


Download         Length: 160 a.a.        Molecular weight: 19855.70 Da        Isoelectric Point: 7.9710

>NTDB_id=535549 I6J38_RS07535 WP_006267672.1 1515718..1516200(+) (comR/comR2) [Streptococcus constellatus strain FDAARGOS_1208]
MDFKELYDKVRGIVLKCRREYYVHLWELSDWDQEGMLVLYELVSRYPQLVESESRLYVYYKTKFRNHIKDILRKQESQKR
KLDRQVYEEVSEIGHKLSLKELYLDELVILRDQLKSYQKQLSPEKQEQYERLLADERFQGRQAMLRELRTYLQDYDERKS

Nucleotide


Download         Length: 483 bp        

>NTDB_id=535549 I6J38_RS07535 WP_006267672.1 1515718..1516200(+) (comR/comR2) [Streptococcus constellatus strain FDAARGOS_1208]
ATGGACTTCAAGGAATTGTATGACAAAGTGAGAGGGATCGTACTGAAGTGTCGCCGGGAATATTATGTCCACCTGTGGGA
GTTAAGTGATTGGGACCAAGAAGGGATGCTGGTCTTATATGAGTTGGTGAGTCGCTATCCGCAACTGGTAGAGTCAGAAA
GTCGTCTCTATGTTTACTATAAGACCAAGTTCCGTAATCACATCAAGGACATCCTGCGCAAACAAGAAAGCCAAAAGCGC
AAACTAGACCGTCAAGTCTATGAGGAAGTGAGCGAGATAGGTCACAAGCTCAGCCTGAAAGAACTCTATTTGGATGAATT
GGTGATTCTCCGAGACCAACTAAAGAGCTATCAAAAACAGCTAAGTCCAGAGAAACAAGAACAGTATGAGCGCTTACTAG
CAGATGAACGGTTTCAAGGACGCCAAGCGATGCTTCGGGAGTTACGGACCTACTTACAAGATTACGATGAAAGAAAAAGC
TAG

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A380L5Q1

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

61.392

98.75

0.606

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

61.392

98.75

0.606

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

56.41

97.5

0.55

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

55.128

97.5

0.537

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

55.128

97.5

0.537

  comX/comX1 Streptococcus pneumoniae R6

55.556

95.625

0.531

  comX/comX1 Streptococcus pneumoniae D39

55.556

95.625

0.531

  comX/comX2 Streptococcus pneumoniae Rx1

55.556

95.625

0.531

  comX/comX1 Streptococcus pneumoniae Rx1

55.556

95.625

0.531

  comX/comX2 Streptococcus pneumoniae D39

55.556

95.625

0.531

  comX/comX2 Streptococcus pneumoniae R6

55.556

95.625

0.531

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

54.487

97.5

0.531

  comX/comX2 Streptococcus pneumoniae TIGR4

54.902

95.625

0.525

  comX/comX1 Streptococcus pneumoniae TIGR4

54.902

95.625

0.525

  comX/sigX Streptococcus mutans UA159

50.318

98.125

0.494

  comX/sigX Streptococcus suis D9

46.452

96.875

0.45

  comX/sigX Streptococcus suis isolate S10

46.452

96.875

0.45

  comX/sigX Streptococcus suis P1/7

46.452

96.875

0.45

  comX Streptococcus salivarius SK126

43.506

96.25

0.419

  comX/sigX Streptococcus salivarius strain HSISS4

42.857

96.25

0.412

  comX Streptococcus thermophilus LMG 18311

42.857

96.25

0.412

  comX Streptococcus thermophilus LMD-9

42.857

96.25

0.412

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40.764

98.125

0.4

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40.764

98.125

0.4

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.764

98.125

0.4

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.764

98.125

0.4

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40.764

98.125

0.4

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40.764

98.125

0.4

  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

39.744

97.5

0.388

  comX Streptococcus sobrinus strain NIDR 6715-7

37.419

96.875

0.362