Detailed information NTG0443304

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HLB24_RS09620
• Genome accession: NZ_CP053183
• Coordinates: 1967671..1968714 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Guangzhou-SAU071
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1962671..1973714

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HLB24_RS09590 (HLB24_09595)	-	1963092..1964348 (-)	1257	WP_078065149.1	aminopeptidase	-
HLB24_RS09595 (HLB24_09600)	-	1964351..1964551 (-)	201	WP_000180460.1	DUF1128 family protein	-
HLB24_RS09600 (HLB24_09605)	-	1964698..1965162 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HLB24_RS09605 (HLB24_09610)	-	1965169..1965444 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HLB24_RS09610 (HLB24_09615)	-	1965722..1966939 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
HLB24_RS09615 (HLB24_09620)	vraR	1967052..1967681 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
HLB24_RS09620 (HLB24_09625)	vraS	1967671..1968714 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HLB24_RS09625 (HLB24_09630)	liaF	1968711..1969412 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HLB24_RS09630 (HLB24_09635)	-	1969427..1969813 (-)	387	WP_111058724.1	hypothetical protein	-
HLB24_RS09635 (HLB24_09640)	map	1970030..1970788 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HLB24_RS09640 (HLB24_09645)	-	1971317..1972303 (+)	987	WP_000999708.1	aromatic acid exporter family protein	-
HLB24_RS09645 (HLB24_09650)	-	1972736..1973149 (-)	414	WP_025174552.1	hypothetical protein	-
HLB24_RS09650 (HLB24_09655)	-	1973178..1973288 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=443304 HLB24_RS09620 WP_001017131.1 1967671..1968714(-) (vraS) [Staphylococcus aureus strain Guangzhou-SAU071]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=443304 HLB24_RS09620 WP_001017131.1 1967671..1968714(-) (vraS) [Staphylococcus aureus strain Guangzhou-SAU071]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1