Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX/comX2/sigX2   Type   Regulator
Locus tag   EGX78_RS08240 Genome accession   NZ_CP033767
Coordinates   1596283..1596768 (-) Length   161 a.a.
NCBI ID   WP_002988129.1    Uniprot ID   A0A6C2W3T2
Organism   Streptococcus pyogenes strain FDAARGOS_534     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1591283..1601768
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EGX78_RS08215 (EGX78_08220) - 1592650..1593495 (+) 846 WP_002982833.1 mechanosensitive ion channel family protein -
  EGX78_RS08220 (EGX78_08225) - 1593560..1594120 (-) 561 WP_002988142.1 TIGR01440 family protein -
  EGX78_RS08225 (EGX78_08230) - 1594134..1594604 (-) 471 WP_002988139.1 ECF transporter S component -
  EGX78_RS08230 (EGX78_08235) - 1594594..1595358 (-) 765 WP_002988136.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
  EGX78_RS08235 (EGX78_08240) truA 1595348..1596097 (-) 750 WP_002988132.1 tRNA pseudouridine(38-40) synthase TruA -
  EGX78_RS08240 (EGX78_08245) comX/sigX/comX2/sigX2 1596283..1596768 (-) 486 WP_002988129.1 competence protein ComX Regulator

Sequence

Protein


Download         Length: 161 a.a.        Molecular weight: 19669.68 Da        Isoelectric Point: 9.5784

>NTDB_id=325529 EGX78_RS08240 WP_002988129.1 1596283..1596768(-) (comX/sigX/comX2/sigX2) [Streptococcus pyogenes strain FDAARGOS_534]
MSIETRAAFEKVKPIILKLKRHYYIQLWDRDDWLQEGHIILLQLLERYPELIEEEERLYRYFKTKFSSYLKDLLRRQESQ
KRQFHKLAYEEIGEVAHAIPSRGLWLDDYVAYQEVIASLENQLNSQERMQFQALIRGERFKGRRALLRKISPYFKEFAQQ
L

Nucleotide


Download         Length: 486 bp        

>NTDB_id=325529 EGX78_RS08240 WP_002988129.1 1596283..1596768(-) (comX/sigX/comX2/sigX2) [Streptococcus pyogenes strain FDAARGOS_534]
ATGTCGATAGAGACAAGAGCAGCGTTTGAAAAAGTTAAGCCCATTATTTTGAAATTAAAGCGACACTATTATATTCAATT
GTGGGATAGAGATGACTGGTTACAAGAAGGACATATTATCTTATTACAGTTACTAGAAAGGTACCCAGAGTTAATTGAGG
AAGAAGAGCGTTTATATCGCTATTTTAAAACAAAATTTTCATCTTATTTGAAAGATTTATTACGCCGTCAAGAAAGTCAA
AAGCGTCAGTTCCATAAGTTAGCATATGAAGAGATAGGGGAGGTTGCACATGCCATTCCATCGAGAGGGTTATGGCTAGA
CGACTATGTGGCTTATCAAGAGGTAATAGCTAGCTTAGAGAACCAATTAAATTCGCAAGAGCGTATGCAGTTTCAAGCAC
TTATCAGGGGCGAACGTTTCAAGGGAAGACGTGCTCTACTTAGGAAGATCAGTCCCTATTTTAAGGAATTTGCACAGCAG
TTGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6C2W3T2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

100

100

1
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

100

100

1
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

99.379

100

0.994
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

99.379

100

0.994
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

99.379

100

0.994
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

99.379

100

0.994
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

49.333

93.168

0.46
  comX Streptococcus sobrinus strain NIDR 6715-7

46.104

95.652

0.441
  comX/sigX Streptococcus mutans UA159

44.444

95.031

0.422
  comX Streptococcus thermophilus LMD-9

42.667

93.168

0.398
  comX Streptococcus salivarius SK126

42.667

93.168

0.398
  comX Streptococcus thermophilus LMG 18311

42.667

93.168

0.398
  comX/sigX Streptococcus salivarius strain HSISS4

42.667

93.168

0.398
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

42.953

92.547

0.398
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

42.282

92.547

0.391
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

40.26

95.652

0.385
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

40.26

95.652

0.385
  comX/sigX Streptococcus suis isolate S10

40

96.273

0.385
  comX/sigX Streptococcus suis D9

40

96.273

0.385
  comX/sigX Streptococcus suis P1/7

40

96.273

0.385
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

40.94

92.547

0.379
  comX/comX2 Streptococcus pneumoniae Rx1

40

93.168

0.373
  comX/comX2 Streptococcus pneumoniae R6

40

93.168

0.373
  comX/comX1 Streptococcus pneumoniae R6

40

93.168

0.373
  comX/comX2 Streptococcus pneumoniae TIGR4

40

93.168

0.373
  comX/comX1 Streptococcus pneumoniae TIGR4

40

93.168

0.373
  comX/comX2 Streptococcus pneumoniae D39

40

93.168

0.373
  comX/comX1 Streptococcus pneumoniae Rx1

40

93.168

0.373
  comX/comX1 Streptococcus pneumoniae D39

40

93.168

0.373
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

40.268

92.547

0.373

Multiple sequence alignment