Detailed information    

insolico Bioinformatically predicted

Overview


Name   comX/sigX   Type   Regulator
Locus tag   DSN71_RS00575 Genome accession   NZ_CP030845
Coordinates   78415..78894 (+) Length   159 a.a.
NCBI ID   WP_001204194.1    Uniprot ID   A0AAV3JNR5
Organism   Streptococcus agalactiae strain S73     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 79073..120423 78415..78894 flank 179


Gene organization within MGE regions


Location: 78415..120423
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DSN71_RS00575 (DSN71_00575) comX/sigX 78415..78894 (+) 480 WP_001204194.1 sigma-70 family RNA polymerase sigma factor Regulator
  DSN71_RS00580 (DSN71_00580) - 79073..80170 (-) 1098 WP_000570848.1 site-specific integrase -
  DSN71_RS00585 (DSN71_00585) - 80347..80556 (-) 210 WP_000520183.1 TM2 domain-containing protein -
  DSN71_RS00590 (DSN71_00590) - 80609..80989 (-) 381 WP_000686776.1 ImmA/IrrE family metallo-endopeptidase -
  DSN71_RS00595 (DSN71_00595) - 80979..81338 (-) 360 WP_000207087.1 helix-turn-helix domain-containing protein -
  DSN71_RS00600 (DSN71_00600) - 81527..81727 (+) 201 WP_001875236.1 helix-turn-helix transcriptional regulator -
  DSN71_RS00605 (DSN71_00605) - 81775..82503 (+) 729 WP_017647877.1 phage antirepressor KilAC domain-containing protein -
  DSN71_RS10935 - 82536..82694 (+) 159 WP_017647876.1 hypothetical protein -
  DSN71_RS10895 - 82691..82984 (-) 294 WP_001104373.1 hypothetical protein -
  DSN71_RS00610 (DSN71_00610) - 83113..83370 (+) 258 WP_001191791.1 hypothetical protein -
  DSN71_RS10940 - 83400..83543 (+) 144 WP_017647875.1 hypothetical protein -
  DSN71_RS00615 (DSN71_00615) - 83572..84330 (+) 759 WP_000546751.1 DnaD domain protein -
  DSN71_RS00620 (DSN71_00620) - 84317..85099 (+) 783 WP_000600244.1 ATP-binding protein -
  DSN71_RS10945 - 85090..85233 (+) 144 WP_017647874.1 hypothetical protein -
  DSN71_RS00625 (DSN71_00625) - 85226..85501 (+) 276 WP_017647873.1 hypothetical protein -
  DSN71_RS00630 (DSN71_00630) - 85488..85742 (+) 255 WP_017647872.1 hypothetical protein -
  DSN71_RS10950 (DSN71_00635) - 85745..85906 (+) 162 WP_017647871.1 hypothetical protein -
  DSN71_RS00640 (DSN71_00640) - 85907..86860 (+) 954 WP_000064172.1 RecT family recombinase -
  DSN71_RS00645 (DSN71_00645) - 86857..87654 (+) 798 WP_017647870.1 PD-(D/E)XK nuclease-like domain-containing protein -
  DSN71_RS00650 (DSN71_00650) - 87817..88014 (+) 198 WP_017647869.1 hypothetical protein -
  DSN71_RS00655 (DSN71_00655) - 88004..88480 (+) 477 WP_017647868.1 RusA family crossover junction endodeoxyribonuclease -
  DSN71_RS00660 (DSN71_00660) - 88470..88817 (+) 348 WP_017647867.1 hypothetical protein -
  DSN71_RS00665 (DSN71_00665) - 88829..89125 (+) 297 WP_017647866.1 nucleotide modification associated domain-containing protein -
  DSN71_RS10955 - 89109..89267 (+) 159 WP_017647865.1 hypothetical protein -
  DSN71_RS00670 (DSN71_00670) - 89264..89647 (+) 384 WP_017647864.1 YopX family protein -
  DSN71_RS10960 (DSN71_00675) - 89644..89808 (+) 165 WP_017647863.1 hypothetical protein -
  DSN71_RS00680 (DSN71_00680) - 89805..90074 (+) 270 WP_017647862.1 hypothetical protein -
  DSN71_RS00685 (DSN71_00685) - 90077..90562 (+) 486 WP_017647861.1 class I SAM-dependent methyltransferase -
  DSN71_RS00690 (DSN71_00690) - 90552..91058 (+) 507 WP_231450180.1 hypothetical protein -
  DSN71_RS00695 (DSN71_00695) - 91062..91631 (+) 570 WP_017647859.1 DUF1642 domain-containing protein -
  DSN71_RS00700 (DSN71_00700) - 91652..91951 (+) 300 WP_001105090.1 hypothetical protein -
  DSN71_RS00705 (DSN71_00705) - 91969..92235 (+) 267 WP_017647858.1 hypothetical protein -
  DSN71_RS00710 (DSN71_00710) - 92625..93059 (+) 435 WP_000142570.1 ArpU family phage packaging/lysis transcriptional regulator -
  DSN71_RS00720 (DSN71_00720) - 94272..94649 (-) 378 WP_017647857.1 type II toxin-antitoxin system HicB family antitoxin -
  DSN71_RS00725 (DSN71_00725) - 94701..94886 (-) 186 WP_001132272.1 type II toxin-antitoxin system HicA family toxin -
  DSN71_RS00730 (DSN71_00730) - 95042..95491 (+) 450 WP_229295347.1 terminase small subunit -
  DSN71_RS00735 (DSN71_00735) - 95478..96719 (+) 1242 WP_017647856.1 PBSX family phage terminase large subunit -
  DSN71_RS00740 (DSN71_00740) - 96732..98225 (+) 1494 WP_017647855.1 phage portal protein -
  DSN71_RS00745 (DSN71_00745) - 98209..99180 (+) 972 WP_017647854.1 minor capsid protein -
  DSN71_RS00750 (DSN71_00750) - 99397..99975 (+) 579 WP_017647853.1 DUF4355 domain-containing protein -
  DSN71_RS00755 (DSN71_00755) - 99985..100368 (+) 384 WP_001042771.1 head decoration protein -
  DSN71_RS00760 (DSN71_00760) - 100368..101420 (+) 1053 WP_001185213.1 major capsid protein -
  DSN71_RS00765 (DSN71_00765) - 101433..101687 (+) 255 WP_001229661.1 HeH/LEM domain-containing protein -
  DSN71_RS00770 (DSN71_00770) - 101703..102056 (+) 354 WP_017647852.1 phage head-tail connector protein -
  DSN71_RS00775 (DSN71_00775) - 102053..102352 (+) 300 WP_017647851.1 hypothetical protein -
  DSN71_RS00780 (DSN71_00780) - 102345..102728 (+) 384 WP_017647850.1 HK97-gp10 family putative phage morphogenesis protein -
  DSN71_RS00785 (DSN71_00785) - 102725..103111 (+) 387 WP_017647849.1 DUF3168 domain-containing protein -
  DSN71_RS00790 (DSN71_00790) - 103120..103605 (+) 486 WP_017647848.1 phage major tail protein, TP901-1 family -
  DSN71_RS00795 (DSN71_00795) - 103721..104080 (+) 360 WP_017647847.1 tail assembly chaperone -
  DSN71_RS00800 (DSN71_00800) - 104182..104460 (+) 279 WP_025194532.1 hypothetical protein -
  DSN71_RS00805 (DSN71_00805) - 104453..107101 (+) 2649 WP_017647846.1 phage tail tape measure protein -
  DSN71_RS00810 (DSN71_00810) - 107102..108664 (+) 1563 WP_017647845.1 distal tail protein Dit -
  DSN71_RS00815 (DSN71_00815) - 108655..113622 (+) 4968 WP_017647844.1 glucosaminidase domain-containing protein -
  DSN71_RS00820 (DSN71_00820) - 113623..115626 (+) 2004 WP_017647843.1 DUF859 family phage minor structural protein -
  DSN71_RS00825 (DSN71_00825) - 115638..116030 (+) 393 WP_000889196.1 DUF1366 domain-containing protein -
  DSN71_RS11145 - 116053..116181 (+) 129 WP_017647842.1 hypothetical protein -
  DSN71_RS00830 (DSN71_00830) - 116190..116492 (+) 303 WP_017647841.1 hypothetical protein -
  DSN71_RS00835 (DSN71_00835) - 116485..116712 (+) 228 WP_000609111.1 phage holin -
  DSN71_RS00840 (DSN71_00840) - 116838..118172 (+) 1335 WP_017647840.1 GH25 family lysozyme -
  DSN71_RS00845 (DSN71_00845) - 118316..118567 (-) 252 WP_000455662.1 hypothetical protein -
  DSN71_RS10965 - 118708..118854 (-) 147 WP_001030869.1 hypothetical protein -
  DSN71_RS00850 (DSN71_00850) - 119004..119213 (+) 210 WP_000424774.1 helix-turn-helix transcriptional regulator -
  DSN71_RS00855 (DSN71_00855) prx 119336..119518 (+) 183 WP_017647839.1 hypothetical protein Regulator
  DSN71_RS00860 (DSN71_00860) - 119731..120423 (+) 693 WP_000049272.1 histidine phosphatase family protein -

Sequence


Protein


Download         Length: 159 a.a.        Molecular weight: 19447.28 Da        Isoelectric Point: 6.2639

>NTDB_id=301811 DSN71_RS00575 WP_001204194.1 78415..78894(+) (comX/sigX) [Streptococcus agalactiae strain S73]
MRDFEELFDKVKPIVMKLRRNYFVQLWEYDDWIQEGRIVLFRLLEEHPYLLDNESKLFIYFKTKFSNYLNDVLRHQDCQK
RQFNKMPYEEISEVSHYVKSKGLVLDDYIAYRDTLTKVEETLSDIDKEKFEKLISGERFAGKKQFIRDIQPFFNAFKAD

Nucleotide


Download         Length: 480 bp        

>NTDB_id=301811 DSN71_RS00575 WP_001204194.1 78415..78894(+) (comX/sigX) [Streptococcus agalactiae strain S73]
TTGAGAGATTTTGAGGAGTTGTTTGATAAAGTAAAGCCAATCGTAATGAAGCTGAGAAGAAATTATTTTGTTCAACTTTG
GGAATATGATGATTGGATTCAAGAAGGACGTATTGTACTTTTTAGGTTGCTTGAAGAGCATCCGTATTTATTGGATAATG
AAAGCAAACTATTCATTTACTTTAAAACAAAATTTTCAAATTATTTAAACGATGTATTAAGACACCAAGATTGTCAAAAG
CGACAATTTAATAAAATGCCTTATGAAGAAATCAGTGAAGTTAGTCACTATGTTAAGAGTAAAGGACTAGTTTTAGATGA
CTATATTGCTTATCGTGATACTTTAACAAAAGTGGAAGAAACTTTGTCAGATATTGATAAAGAAAAATTTGAAAAACTGA
TTAGTGGTGAACGTTTTGCGGGGAAGAAACAATTCATACGAGATATTCAACCTTTTTTCAATGCTTTTAAAGCGGATTAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

56.688

98.742

0.56

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

52.349

93.711

0.491

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

52.349

93.711

0.491

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

52

94.34

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

52

94.34

0.491

  comX/sigX Streptococcus mutans UA159

49.677

97.484

0.484

  comX Streptococcus sobrinus strain NIDR 6715-7

43.59

98.113

0.428

  comX/sigX Streptococcus suis D9

43.226

97.484

0.421

  comX/sigX Streptococcus suis isolate S10

43.226

97.484

0.421

  comX/sigX Streptococcus suis P1/7

43.226

97.484

0.421

  comX Streptococcus thermophilus LMD-9

42.177

92.453

0.39

  comX Streptococcus thermophilus LMG 18311

42.177

92.453

0.39

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384

  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

39.869

96.226

0.384

  comX/comX2 Streptococcus pneumoniae Rx1

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae Rx1

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae D39

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae D39

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae R6

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae R6

40.397

94.969

0.384

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

39.216

96.226

0.377

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

39.216

96.226

0.377

  comX Streptococcus salivarius SK126

40.816

92.453

0.377

  comX/sigX Streptococcus salivarius strain HSISS4

40.816

92.453

0.377

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

38.562

96.226

0.371


Multiple sequence alignment