Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   CWI26_RS00085 Genome accession   NZ_CP025043
Coordinates   16233..16703 (+) Length   156 a.a.
NCBI ID   WP_002936602.1    Uniprot ID   A0A075SE61
Organism   Streptococcus suis strain AH681     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 13908..42441 16233..16703 within 0


Gene organization within MGE regions


Location: 13908..42441
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CWI26_RS00080 (CWI26_00080) ftsH 13908..15881 (+) 1974 WP_029185671.1 ATP-dependent zinc metalloprotease FtsH -
  CWI26_RS00085 (CWI26_00085) comX/sigX 16233..16703 (+) 471 WP_002936602.1 sigma-70 family RNA polymerase sigma factor Regulator
  CWI26_RS00195 (CWI26_00195) mreC 24148..24984 (+) 837 WP_024419582.1 rod shape-determining protein MreC -
  CWI26_RS00200 (CWI26_00200) mreD 24986..25489 (+) 504 WP_228377880.1 rod shape-determining protein MreD -
  CWI26_RS00205 (CWI26_00205) pcsB 25574..26815 (+) 1242 WP_024419580.1 peptidoglycan hydrolase PcsB -
  CWI26_RS00210 (CWI26_00210) - 26918..27886 (+) 969 WP_002935337.1 ribose-phosphate diphosphokinase -
  CWI26_RS00215 (CWI26_00215) - 27973..29151 (+) 1179 WP_024375938.1 pyridoxal phosphate-dependent aminotransferase -
  CWI26_RS00220 (CWI26_00220) recO 29138..29920 (+) 783 WP_024375937.1 DNA repair protein RecO -
  CWI26_RS00225 (CWI26_00225) plsX 29917..30924 (+) 1008 WP_100881012.1 phosphate acyltransferase PlsX -
  CWI26_RS00230 (CWI26_00230) - 30917..31165 (+) 249 WP_100881013.1 phosphopantetheine-binding protein -
  CWI26_RS00235 (CWI26_00235) purC 31283..31990 (+) 708 WP_100881014.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  CWI26_RS00240 (CWI26_00240) - 32003..35722 (+) 3720 WP_100881015.1 phosphoribosylformylglycinamidine synthase -
  CWI26_RS00245 (CWI26_00245) purF 35725..37179 (+) 1455 WP_100881016.1 amidophosphoribosyltransferase -
  CWI26_RS00250 (CWI26_00250) purM 37235..38258 (+) 1024 Protein_27 phosphoribosylformylglycinamidine cyclo-ligase -
  CWI26_RS00255 (CWI26_00255) purN 38255..38812 (+) 558 WP_024378575.1 phosphoribosylglycinamide formyltransferase -
  CWI26_RS00260 (CWI26_00260) - 38809..38967 (+) 159 WP_099776336.1 phosphoribosylaminoimidazolecarboxamide formyltransferase -
  CWI26_RS00265 (CWI26_00265) purH 38992..40539 (+) 1548 WP_100881017.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  CWI26_RS12300 - 40752..40880 (+) 129 WP_257060737.1 hypothetical protein -
  CWI26_RS00270 (CWI26_00270) - 40877..41653 (+) 777 WP_158293385.1 ABC-2 family transporter protein -
  CWI26_RS00275 (CWI26_00275) - 41656..42441 (+) 786 WP_029177286.1 ABC transporter permease -

Sequence

Protein


Download         Length: 156 a.a.        Molecular weight: 19072.97 Da        Isoelectric Point: 8.9339

>NTDB_id=257581 CWI26_RS00085 WP_002936602.1 16233..16703(+) (comX/sigX) [Streptococcus suis strain AH681]
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKR
KFDRMPHEDIHELSHAIQSPGLINDELLMLRGALRDYRKNLSNDQLDKYEKLISGQCFNGRREMIRDLQIHLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=257581 CWI26_RS00085 WP_002936602.1 16233..16703(+) (comX/sigX) [Streptococcus suis strain AH681]
ATGGAATTCGAAAAAGTGTACGCAAGCGTCAAAGGTATTGTAAACAAGGCTCGAAAAGAGTTTTACATTAAACTATGGGA
TCGAGATGATTGGGAACAAGAAGGAATGATGACCTTGTTTGAATTGTTGGAAGCTCAACCGTGGCTAGTTGATGAACAAG
TTCAATTATATTGTTATTTTAAAGTCAAGTTCAGAAATCGCATCAAAGATCGTATCCGCAAACAGGAAAGTCAAAAACGC
AAGTTTGACCGAATGCCACATGAAGATATTCACGAATTATCTCATGCAATACAATCACCGGGATTGATAAACGATGAACT
ATTAATGTTGAGAGGTGCCTTGAGAGATTATCGAAAAAATCTGAGTAATGATCAACTTGATAAATACGAAAAATTAATTA
GCGGACAATGTTTTAATGGTCGTCGTGAAATGATACGTGATTTACAAATTCATTTGAAAGACTTTCGCTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A075SE61

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

100

100

1
  comX/sigX Streptococcus suis isolate S10

99.359

100

0.994
  comX/sigX Streptococcus suis P1/7

99.359

100

0.994
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487
  comX/comX1 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449
  comX/comX2 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

45.752

98.077

0.449
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

45.098

98.077

0.442
  comX/comX1 Streptococcus pneumoniae Rx1

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae D39

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae D39

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae R6

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae R6

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae Rx1

45.695

96.795

0.442
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

44.444

98.077

0.436
  comX/sigX Streptococcus mutans UA159

43.226

99.359

0.429
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX Streptococcus sobrinus strain NIDR 6715-7

40.523

98.077

0.397
  comX Streptococcus thermophilus LMG 18311

40.523

98.077

0.397
  comX Streptococcus thermophilus LMD-9

40.523

98.077

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.854

100

0.391
  comX Streptococcus salivarius SK126

39.869

98.077

0.391
  comX/sigX Streptococcus salivarius strain HSISS4

39.869

98.077

0.391

Multiple sequence alignment