Detailed information    

insolico Bioinformatically predicted

Overview


Name   comX/sigX   Type   Regulator
Locus tag   BB268_RS00630 Genome accession   NZ_CP021866
Coordinates   81077..81556 (+) Length   159 a.a.
NCBI ID   WP_001204194.1    Uniprot ID   A0AAV3JNR5
Organism   Streptococcus agalactiae strain SG-M29     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 81735..124321 81077..81556 flank 179


Gene organization within MGE regions


Location: 81077..124321
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BB268_RS00630 (BB268_00630) comX/sigX 81077..81556 (+) 480 WP_001204194.1 sigma-70 family RNA polymerase sigma factor Regulator
  BB268_RS00635 (BB268_00635) - 81735..82832 (-) 1098 WP_000570848.1 site-specific integrase -
  BB268_RS11625 - 83453..83692 (-) 240 Protein_75 hypothetical protein -
  BB268_RS00645 (BB268_00645) - 83701..84078 (-) 378 WP_053515022.1 ImmA/IrrE family metallo-endopeptidase -
  BB268_RS00650 (BB268_00650) - 84062..84403 (-) 342 WP_053515023.1 helix-turn-helix domain-containing protein -
  BB268_RS00655 (BB268_00655) - 84599..84811 (+) 213 WP_053515024.1 helix-turn-helix transcriptional regulator -
  BB268_RS00660 (BB268_00660) - 84840..85565 (+) 726 WP_053515025.1 phage antirepressor KilAC domain-containing protein -
  BB268_RS11280 - 85598..85756 (+) 159 WP_017647876.1 hypothetical protein -
  BB268_RS00665 (BB268_00665) - 85753..86046 (-) 294 WP_001104373.1 hypothetical protein -
  BB268_RS00670 (BB268_00670) - 86175..86432 (+) 258 WP_001191791.1 hypothetical protein -
  BB268_RS11285 - 86462..86605 (+) 144 WP_172798516.1 hypothetical protein -
  BB268_RS00675 (BB268_00675) - 86681..86881 (+) 201 WP_001058282.1 hypothetical protein -
  BB268_RS00680 (BB268_00680) - 86878..87168 (+) 291 WP_000650504.1 hypothetical protein -
  BB268_RS00685 (BB268_00685) - 87155..87838 (+) 684 WP_000704951.1 AAA family ATPase -
  BB268_RS00690 (BB268_00690) - 87895..89280 (+) 1386 WP_235462353.1 DEAD/DEAH box helicase -
  BB268_RS00695 (BB268_00695) - 89293..89775 (+) 483 WP_053515027.1 DUF669 domain-containing protein -
  BB268_RS00700 (BB268_00700) - 89793..91346 (+) 1554 WP_053515028.1 hypothetical protein -
  BB268_RS00705 (BB268_00705) - 91591..92457 (+) 867 WP_053515029.1 bifunctional DNA primase/polymerase -
  BB268_RS00710 (BB268_00710) - 92483..92767 (+) 285 WP_053515072.1 VRR-NUC domain-containing protein -
  BB268_RS00715 (BB268_00715) - 92846..93142 (+) 297 WP_000763916.1 nucleotide modification associated domain-containing protein -
  BB268_RS11290 - 93126..93284 (+) 159 WP_017646174.1 hypothetical protein -
  BB268_RS00720 (BB268_00720) - 93281..93661 (+) 381 WP_053515030.1 YopX family protein -
  BB268_RS00725 (BB268_00725) - 93658..93822 (+) 165 WP_000159367.1 hypothetical protein -
  BB268_RS00730 (BB268_00730) - 93819..94088 (+) 270 WP_053515031.1 hypothetical protein -
  BB268_RS00735 (BB268_00735) - 94090..94440 (+) 351 WP_225971866.1 HNH endonuclease -
  BB268_RS00740 (BB268_00740) - 94444..94926 (+) 483 WP_053515033.1 class I SAM-dependent methyltransferase -
  BB268_RS00745 (BB268_00745) - 95129..95692 (+) 564 WP_053515034.1 DUF1642 domain-containing protein -
  BB268_RS00750 (BB268_00750) - 95679..95996 (+) 318 WP_053515035.1 hypothetical protein -
  BB268_RS00755 (BB268_00755) - 96014..96232 (+) 219 WP_053515036.1 hypothetical protein -
  BB268_RS00765 (BB268_00765) - 96922..97356 (+) 435 WP_000142570.1 ArpU family phage packaging/lysis transcriptional regulator -
  BB268_RS11295 - 97533..97670 (-) 138 WP_158472040.1 hypothetical protein -
  BB268_RS00775 (BB268_00775) - 98560..98940 (+) 381 WP_000090087.1 hypothetical protein -
  BB268_RS00780 (BB268_00780) - 98930..100204 (+) 1275 WP_000634503.1 PBSX family phage terminase large subunit -
  BB268_RS00785 (BB268_00785) - 100204..101529 (+) 1326 WP_065367292.1 phage portal protein -
  BB268_RS00790 (BB268_00790) - 101498..102424 (+) 927 Protein_107 minor capsid protein -
  BB268_RS00795 (BB268_00795) - 102558..102884 (+) 327 WP_053515038.1 hypothetical protein -
  BB268_RS00800 (BB268_00800) - 102998..103567 (+) 570 WP_053515039.1 DUF4355 domain-containing protein -
  BB268_RS00805 (BB268_00805) - 103586..104476 (+) 891 WP_053515040.1 hypothetical protein -
  BB268_RS00810 (BB268_00810) - 104489..104782 (+) 294 WP_053515041.1 HeH/LEM domain-containing protein -
  BB268_RS00815 (BB268_00815) - 104796..105140 (+) 345 WP_053515042.1 hypothetical protein -
  BB268_RS00820 (BB268_00820) - 105137..105448 (+) 312 WP_053515043.1 hypothetical protein -
  BB268_RS00825 (BB268_00825) - 105445..105840 (+) 396 WP_053515044.1 hypothetical protein -
  BB268_RS00830 (BB268_00830) - 105842..106252 (+) 411 WP_053515045.1 DUF5072 family protein -
  BB268_RS00835 (BB268_00835) - 106264..106770 (+) 507 WP_053515046.1 phage major tail protein, TP901-1 family -
  BB268_RS00840 (BB268_00840) - 106783..107100 (+) 318 WP_053515047.1 hypothetical protein -
  BB268_RS00845 (BB268_00845) - 107232..107531 (+) 300 WP_235462347.1 hypothetical protein -
  BB268_RS00850 (BB268_00850) - 107524..109722 (+) 2199 WP_053515049.1 phage tail protein -
  BB268_RS00855 (BB268_00855) - 109733..111241 (+) 1509 WP_053515074.1 distal tail protein Dit -
  BB268_RS00860 (BB268_00860) - 111232..116199 (+) 4968 WP_053515050.1 glucosaminidase domain-containing protein -
  BB268_RS00865 (BB268_00865) - 116200..118203 (+) 2004 WP_053515051.1 DUF859 family phage minor structural protein -
  BB268_RS00870 (BB268_00870) - 118215..118607 (+) 393 WP_000889196.1 DUF1366 domain-containing protein -
  BB268_RS11510 - 118630..118758 (+) 129 WP_017647842.1 hypothetical protein -
  BB268_RS00875 (BB268_00875) - 118767..119069 (+) 303 WP_017647841.1 hypothetical protein -
  BB268_RS00880 (BB268_00880) - 119062..119289 (+) 228 WP_000609111.1 phage holin -
  BB268_RS00885 (BB268_00885) - 119415..120749 (+) 1335 WP_017647840.1 GH25 family lysozyme -
  BB268_RS00890 (BB268_00890) - 120893..121144 (-) 252 WP_000455662.1 hypothetical protein -
  BB268_RS11300 - 121285..121431 (-) 147 WP_001030869.1 hypothetical protein -
  BB268_RS00895 (BB268_00895) - 121581..121790 (+) 210 WP_000424774.1 helix-turn-helix domain-containing protein -
  BB268_RS00900 (BB268_00900) prx 121913..122095 (+) 183 WP_017647839.1 hypothetical protein Regulator
  BB268_RS00905 (BB268_00905) - 122308..123000 (+) 693 WP_000049272.1 histidine phosphatase family protein -
  BB268_RS00910 (BB268_00910) - 122997..123749 (+) 753 WP_000739808.1 M15 family metallopeptidase -
  BB268_RS00915 (BB268_00915) - 123746..124321 (+) 576 WP_001231504.1 glycoside hydrolase family 73 protein -

Sequence


Protein


Download         Length: 159 a.a.        Molecular weight: 19447.28 Da        Isoelectric Point: 6.2639

>NTDB_id=234047 BB268_RS00630 WP_001204194.1 81077..81556(+) (comX/sigX) [Streptococcus agalactiae strain SG-M29]
MRDFEELFDKVKPIVMKLRRNYFVQLWEYDDWIQEGRIVLFRLLEEHPYLLDNESKLFIYFKTKFSNYLNDVLRHQDCQK
RQFNKMPYEEISEVSHYVKSKGLVLDDYIAYRDTLTKVEETLSDIDKEKFEKLISGERFAGKKQFIRDIQPFFNAFKAD

Nucleotide


Download         Length: 480 bp        

>NTDB_id=234047 BB268_RS00630 WP_001204194.1 81077..81556(+) (comX/sigX) [Streptococcus agalactiae strain SG-M29]
TTGAGAGATTTTGAGGAGTTGTTTGATAAAGTAAAGCCAATCGTAATGAAGCTGAGAAGAAATTATTTTGTTCAACTTTG
GGAATATGATGATTGGATTCAAGAAGGACGTATTGTACTTTTTAGGTTGCTTGAAGAGCATCCGTATTTATTGGATAATG
AAAGCAAACTATTCATTTACTTTAAAACAAAATTTTCAAATTATTTAAACGATGTATTAAGACACCAAGATTGTCAAAAG
CGACAATTTAATAAAATGCCTTATGAAGAAATCAGTGAAGTTAGTCACTATGTTAAGAGTAAAGGACTAGTTTTAGATGA
CTATATTGCTTATCGTGATACTTTAACAAAAGTGGAAGAAACTTTGTCAGATATTGATAAAGAAAAATTTGAAAAACTGA
TTAGTGGTGAACGTTTTGCGGGGAAGAAACAATTCATACGAGATATTCAACCTTTTTTCAATGCTTTTAAAGCGGATTAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

56.688

98.742

0.56

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

52.349

93.711

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

52.349

93.711

0.491

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

52.349

93.711

0.491

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

52

94.34

0.491

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

52

94.34

0.491

  comX/sigX Streptococcus mutans UA159

49.677

97.484

0.484

  comX Streptococcus sobrinus strain NIDR 6715-7

43.59

98.113

0.428

  comX/sigX Streptococcus suis D9

43.226

97.484

0.421

  comX/sigX Streptococcus suis isolate S10

43.226

97.484

0.421

  comX/sigX Streptococcus suis P1/7

43.226

97.484

0.421

  comX Streptococcus thermophilus LMD-9

42.177

92.453

0.39

  comX Streptococcus thermophilus LMG 18311

42.177

92.453

0.39

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384

  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

39.869

96.226

0.384

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

39.869

96.226

0.384

  comX/comX2 Streptococcus pneumoniae Rx1

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae TIGR4

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae Rx1

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae D39

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae D39

40.397

94.969

0.384

  comX/comX2 Streptococcus pneumoniae R6

40.397

94.969

0.384

  comX/comX1 Streptococcus pneumoniae R6

40.397

94.969

0.384

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

39.216

96.226

0.377

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

39.216

96.226

0.377

  comX Streptococcus salivarius SK126

40.816

92.453

0.377

  comX/sigX Streptococcus salivarius strain HSISS4

40.816

92.453

0.377

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

38.562

96.226

0.371


Multiple sequence alignment