Detailed information NTG0165032

Bioinformatically predicted

Overview

• Name: comX/sigX/comX2/sigX2
• Type: Regulator
• Locus tag: MGAS11027_RS07475
• Genome accession: NZ_CP013838
• Coordinates: 1517251..1517736 (-)
• Length: 161 a.a.
• NCBI ID: WP_002988129.1
• Uniprot ID: A0A6C2W3T2
• Organism: Streptococcus pyogenes strain MGAS11027
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1512251..1522736

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS11027_RS07450 (MGAS11027_1522)	-	1513617..1514462 (+)	846	WP_002982833.1	mechanosensitive ion channel family protein	-
MGAS11027_RS07455 (MGAS11027_1523)	-	1514527..1515087 (-)	561	WP_031488688.1	TIGR01440 family protein	-
MGAS11027_RS07460 (MGAS11027_1524)	-	1515101..1515571 (-)	471	WP_031488687.1	ECF transporter S component	-
MGAS11027_RS07465 (MGAS11027_1525)	-	1515561..1516325 (-)	765	WP_031488686.1	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	-
MGAS11027_RS07470 (MGAS11027_1526)	truA	1516315..1517064 (-)	750	WP_002988132.1	tRNA pseudouridine(38-40) synthase TruA	-
MGAS11027_RS07475 (MGAS11027_1527)	comX/sigX/comX2/sigX2	1517251..1517736 (-)	486	WP_002988129.1	competence protein ComX	Regulator

Sequence

Protein

• Length: 161 a.a.
• Molecular weight: 19669.68 Da
• Isoelectric Point: 9.5784

>NTDB_id=165032 MGAS11027_RS07475 WP_002988129.1 1517251..1517736(-) (comX/sigX/comX2/sigX2) [Streptococcus pyogenes strain MGAS11027]
MSIETRAAFEKVKPIILKLKRHYYIQLWDRDDWLQEGHIILLQLLERYPELIEEEERLYRYFKTKFSSYLKDLLRRQESQ
KRQFHKLAYEEIGEVAHAIPSRGLWLDDYVAYQEVIASLENQLNSQERMQFQALIRGERFKGRRALLRKISPYFKEFAQQ
L

Nucleotide

• Length: 486 bp

>NTDB_id=165032 MGAS11027_RS07475 WP_002988129.1 1517251..1517736(-) (comX/sigX/comX2/sigX2) [Streptococcus pyogenes strain MGAS11027]
ATGTCGATAGAGACAAGAGCAGCGTTTGAAAAAGTTAAGCCCATTATTTTGAAATTAAAGCGACACTATTATATTCAATT
GTGGGATAGAGATGACTGGTTACAAGAAGGACATATTATCTTATTACAGTTACTAGAAAGGTACCCAGAGTTAATTGAGG
AAGAAGAGCGTTTATATCGCTATTTTAAAACAAAATTTTCATCTTATTTGAAAGATTTATTACGCCGTCAAGAAAGTCAA
AAGCGTCAGTTCCATAAGTTAGCATATGAAGAGATAGGGGAGGTTGCACATGCCATTCCATCGAGAGGGTTATGGCTAGA
CGACTATGTGGCTTATCAAGAGGTAATAGCTAGCTTAGAGAACCAATTAAATTCGCAAGAGCGTATGCAGTTTCAAGCAC
TTATCAGGGGCGAACGTTTCAAGGGAAGACGTGCTCTACTTAGGAAGATCAGTCCCTATTTTAAGGAATTTGCACAGCAG
TTGTAA

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A6C2W3T2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	100	100	1
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	100	100	1
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	99.379	100	0.994
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	99.379	100	0.994
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	99.379	100	0.994
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	99.379	100	0.994
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	49.333	93.168	0.46
comX	Streptococcus sobrinus strain NIDR 6715-7	46.104	95.652	0.441
comX/sigX	Streptococcus mutans UA159	44.444	95.031	0.422
comX	Streptococcus thermophilus LMD-9	42.667	93.168	0.398
comX	Streptococcus salivarius SK126	42.667	93.168	0.398
comX	Streptococcus thermophilus LMG 18311	42.667	93.168	0.398
comX/sigX	Streptococcus salivarius strain HSISS4	42.667	93.168	0.398
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	42.953	92.547	0.398
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	42.282	92.547	0.391
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	40.26	95.652	0.385
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	40.26	95.652	0.385
comX/sigX	Streptococcus suis isolate S10	40	96.273	0.385
comX/sigX	Streptococcus suis D9	40	96.273	0.385
comX/sigX	Streptococcus suis P1/7	40	96.273	0.385
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	40.94	92.547	0.379
comX/comX2	Streptococcus pneumoniae Rx1	40	93.168	0.373
comX/comX2	Streptococcus pneumoniae R6	40	93.168	0.373
comX/comX1	Streptococcus pneumoniae R6	40	93.168	0.373
comX/comX2	Streptococcus pneumoniae TIGR4	40	93.168	0.373
comX/comX1	Streptococcus pneumoniae TIGR4	40	93.168	0.373
comX/comX2	Streptococcus pneumoniae D39	40	93.168	0.373
comX/comX1	Streptococcus pneumoniae Rx1	40	93.168	0.373
comX/comX1	Streptococcus pneumoniae D39	40	93.168	0.373
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	40.268	92.547	0.373