Detailed information    

insolico Bioinformatically predicted

Overview


Name   comX/sigX   Type   Regulator
Locus tag   APQ97_RS00530 Genome accession   NZ_CP012911
Coordinates   84474..84944 (+) Length   156 a.a.
NCBI ID   WP_002936602.1    Uniprot ID   A0A075SE61
Organism   Streptococcus suis strain NSUI060     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 82024..151668 84474..84944 within 0
IScluster/Tn 82024..84267 84474..84944 flank 207


Gene organization within MGE regions


Location: 82024..151668
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  APQ97_RS00515 (APQ97_00515) - 82024..83280 (+) 1257 WP_002936184.1 ISL3-like element ISSsu6 family transposase -
  APQ97_RS11595 - 83412..84267 (+) 856 Protein_89 IS982 family transposase -
  APQ97_RS00530 (APQ97_00530) comX/sigX 84474..84944 (+) 471 WP_002936602.1 sigma-70 family RNA polymerase sigma factor Regulator
  APQ97_RS00635 (APQ97_00635) mreC 92246..93082 (+) 837 WP_002935340.1 rod shape-determining protein MreC -
  APQ97_RS00640 (APQ97_00640) mreD 93099..93587 (+) 489 WP_009908846.1 rod shape-determining protein MreD -
  APQ97_RS00645 (APQ97_00645) - 93672..94928 (+) 1257 WP_002935338.1 CHAP domain-containing protein -
  APQ97_RS00650 (APQ97_00650) - 95031..95999 (+) 969 WP_002935337.1 ribose-phosphate diphosphokinase -
  APQ97_RS00655 (APQ97_00655) - 96086..97264 (+) 1179 WP_002935336.1 pyridoxal phosphate-dependent aminotransferase -
  APQ97_RS00660 (APQ97_00660) recO 97251..98033 (+) 783 WP_002935335.1 DNA repair protein RecO -
  APQ97_RS00665 (APQ97_00665) plsX 98030..99037 (+) 1008 WP_002935334.1 phosphate acyltransferase PlsX -
  APQ97_RS00670 (APQ97_00670) - 99030..99278 (+) 249 WP_002935333.1 phosphopantetheine-binding protein -
  APQ97_RS00675 (APQ97_00675) purC 99396..100103 (+) 708 WP_002935328.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  APQ97_RS00680 (APQ97_00680) - 100116..103835 (+) 3720 WP_002935327.1 phosphoribosylformylglycinamidine synthase -
  APQ97_RS00685 (APQ97_00685) purF 103838..105292 (+) 1455 WP_002935326.1 amidophosphoribosyltransferase -
  APQ97_RS00690 (APQ97_00690) purM 105348..106370 (+) 1023 WP_002935325.1 phosphoribosylformylglycinamidine cyclo-ligase -
  APQ97_RS00695 (APQ97_00695) purN 106367..106918 (+) 552 WP_002935324.1 phosphoribosylglycinamide formyltransferase -
  APQ97_RS00700 (APQ97_00700) purH 106928..108475 (+) 1548 WP_002935323.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  APQ97_RS00705 (APQ97_00705) - 108540..109370 (+) 831 WP_002935322.1 DNA adenine methylase -
  APQ97_RS00710 (APQ97_00710) - 109360..110175 (+) 816 WP_032499218.1 site-specific DNA-methyltransferase -
  APQ97_RS00715 (APQ97_00715) - 110153..111079 (+) 927 WP_002935320.1 type II restriction endonuclease -
  APQ97_RS00720 (APQ97_00720) - 111079..111984 (+) 906 WP_002935319.1 type II restriction endonuclease -
  APQ97_RS00725 (APQ97_00725) purD 112105..113367 (+) 1263 WP_002935318.1 phosphoribosylamine--glycine ligase -
  APQ97_RS00730 (APQ97_00730) purE 113393..113881 (+) 489 WP_002935317.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  APQ97_RS00735 (APQ97_00735) purK 113868..114953 (+) 1086 WP_002935314.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  APQ97_RS00740 (APQ97_00740) - 114940..115863 (+) 924 WP_002935313.1 DUF4268 domain-containing protein -
  APQ97_RS00745 (APQ97_00745) purB 115898..117190 (+) 1293 WP_002935312.1 adenylosuccinate lyase -
  APQ97_RS00750 (APQ97_00750) - 117699..118523 (+) 825 WP_002935311.1 ABC transporter ATP-binding protein -
  APQ97_RS00755 (APQ97_00755) - 118516..119250 (+) 735 WP_002935310.1 ABC transporter permease -
  APQ97_RS00760 (APQ97_00760) - 119585..120313 (+) 729 WP_002935309.1 hypothetical protein -
  APQ97_RS00765 (APQ97_00765) - 120323..120901 (+) 579 WP_002935308.1 CPBP family intramembrane glutamic endopeptidase -
  APQ97_RS00770 (APQ97_00770) - 120916..121344 (+) 429 WP_053866406.1 Msa family membrane protein -
  APQ97_RS00775 (APQ97_00775) - 121337..122209 (+) 873 WP_002935305.1 ABC transporter ATP-binding protein -
  APQ97_RS00780 (APQ97_00780) - 122215..122985 (+) 771 WP_002935304.1 membrane protein -
  APQ97_RS00785 (APQ97_00785) - 122988..124700 (+) 1713 WP_002935303.1 ABC transporter ATP-binding protein -
  APQ97_RS12510 - 124802..124975 (+) 174 WP_002935301.1 hypothetical protein -
  APQ97_RS00790 (APQ97_00790) ruvB 125270..126271 (+) 1002 WP_002935300.1 Holliday junction branch migration DNA helicase RuvB -
  APQ97_RS00795 (APQ97_00795) - 126271..127017 (+) 747 WP_002935299.1 GNAT family N-acetyltransferase -
  APQ97_RS00800 (APQ97_00800) - 127019..127657 (+) 639 WP_002935298.1 HAD-IA family hydrolase -
  APQ97_RS00805 (APQ97_00805) comR 127904..128821 (+) 918 WP_002935296.1 helix-turn-helix domain-containing protein Regulator
  APQ97_RS00810 (APQ97_00810) - 129230..130432 (-) 1203 WP_002935295.1 IS110-like element ISSsu7 family transposase -
  APQ97_RS00815 (APQ97_00815) - 130679..131386 (+) 708 Protein_128 amino acid ABC transporter permease -
  APQ97_RS00820 (APQ97_00820) - 131386..132129 (+) 744 WP_013730659.1 amino acid ABC transporter ATP-binding protein -
  APQ97_RS00825 (APQ97_00825) nrdD 132435..134606 (+) 2172 WP_002939131.1 anaerobic ribonucleoside-triphosphate reductase -
  APQ97_RS12770 (APQ97_00830) - 134699..134833 (+) 135 WP_002939130.1 hypothetical protein -
  APQ97_RS00835 (APQ97_00835) - 134835..136181 (+) 1347 WP_009910991.1 5'-nucleotidase C-terminal domain-containing protein -
  APQ97_RS00840 (APQ97_00840) - 136183..136677 (+) 495 WP_002939125.1 GNAT family N-acetyltransferase -
  APQ97_RS00850 (APQ97_00850) nrdG 136864..137421 (+) 558 WP_002939123.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  APQ97_RS00865 (APQ97_00860) - 137902..139188 (-) 1287 WP_002939120.1 replication-associated recombination protein A -
  APQ97_RS00870 (APQ97_00865) - 139262..139732 (+) 471 WP_002939116.1 DUF3013 family protein -
  APQ97_RS00875 (APQ97_00870) - 139734..140087 (+) 354 WP_009910982.1 ASCH domain-containing protein -
  APQ97_RS00880 (APQ97_00875) prmA 140683..141636 (+) 954 WP_002939103.1 50S ribosomal protein L11 methyltransferase -
  APQ97_RS00885 (APQ97_00880) - 141638..142384 (+) 747 WP_002939095.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
  APQ97_RS00890 (APQ97_00885) - 142398..143660 (+) 1263 WP_002939093.1 hypothetical protein -
  APQ97_RS12500 (APQ97_00890) - 143670..144385 (+) 716 Protein_141 DUF554 domain-containing protein -
  APQ97_RS00900 (APQ97_00895) - 144626..145183 (+) 558 WP_002939087.1 hypothetical protein -
  APQ97_RS00905 (APQ97_00900) - 145413..146669 (+) 1257 WP_002936184.1 ISL3-like element ISSsu6 family transposase -
  APQ97_RS00910 (APQ97_00905) - 146727..149203 (-) 2477 Protein_144 bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase -
  APQ97_RS00915 (APQ97_00910) - 149467..151668 (+) 2202 WP_024394201.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -

Sequence


Protein


Download         Length: 156 a.a.        Molecular weight: 19072.97 Da        Isoelectric Point: 8.9339

>NTDB_id=158193 APQ97_RS00530 WP_002936602.1 84474..84944(+) (comX/sigX) [Streptococcus suis strain NSUI060]
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKR
KFDRMPHEDIHELSHAIQSPGLINDELLMLRGALRDYRKNLSNDQLDKYEKLISGQCFNGRREMIRDLQIHLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=158193 APQ97_RS00530 WP_002936602.1 84474..84944(+) (comX/sigX) [Streptococcus suis strain NSUI060]
ATGGAATTCGAAAAAGTGTACGCAAGCGTCAAAGGTATTGTAAATAAGGCTCGAAAAGAGTTTTACATTAAACTATGGGA
TCGAGATGATTGGGAACAAGAAGGAATGATGACCTTGTTTGAATTGTTGGAAGCTCAACCGTGGCTAGTTGATGAACAAG
TTCAATTATATTGTTATTTTAAAGTCAAGTTCAGAAATCGAATCAAGGATCGTATCCGCAAACAGGAAAGTCAAAAACGC
AAGTTTGACCGTATGCCACATGAAGATATTCACGAATTATCTCACGCAATACAATCACCGGGATTAATAAACGATGAACT
ATTAATGCTAAGAGGTGCCTTGAGAGATTATCGAAAAAATCTGAGTAATGATCAACTTGATAAATACGAAAAATTAATTA
GCGGACAATGTTTTAATGGTCGCCGTGAAATGATACGTGATTTACAAATTCATTTGAAAGACTTTCGCTAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A075SE61

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

100

100

1

  comX/sigX Streptococcus suis isolate S10

99.359

100

0.994

  comX/sigX Streptococcus suis P1/7

99.359

100

0.994

  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

49.032

99.359

0.487

  comX/comX1 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449

  comX/comX2 Streptococcus pneumoniae TIGR4

46.358

96.795

0.449

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

45.752

98.077

0.449

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

45.098

98.077

0.442

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

45.098

98.077

0.442

  comX/comX1 Streptococcus pneumoniae Rx1

45.695

96.795

0.442

  comX/comX2 Streptococcus pneumoniae D39

45.695

96.795

0.442

  comX/comX1 Streptococcus pneumoniae D39

45.695

96.795

0.442

  comX/comX2 Streptococcus pneumoniae R6

45.695

96.795

0.442

  comX/comX1 Streptococcus pneumoniae R6

45.695

96.795

0.442

  comX/comX2 Streptococcus pneumoniae Rx1

45.695

96.795

0.442

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

44.444

98.077

0.436

  comX/sigX Streptococcus mutans UA159

43.226

99.359

0.429

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.645

99.359

0.404

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.645

99.359

0.404

  comX Streptococcus sobrinus strain NIDR 6715-7

40.523

98.077

0.397

  comX Streptococcus thermophilus LMG 18311

40.523

98.077

0.397

  comX Streptococcus thermophilus LMD-9

40.523

98.077

0.397

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

99.359

0.397

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

99.359

0.397

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

99.359

0.397

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

99.359

0.397

  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.854

100

0.391

  comX Streptococcus salivarius SK126

39.869

98.077

0.391

  comX/sigX Streptococcus salivarius strain HSISS4

39.869

98.077

0.391


Multiple sequence alignment