Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR/comR2   Type   Regulator
Locus tag   SanJ4206_RS00075 Genome accession   NZ_CP012719
Coordinates   15243..15716 (+) Length   157 a.a.
NCBI ID   WP_022525268.1    Uniprot ID   -
Organism   Streptococcus anginosus strain J4206     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 12936..56047 15243..15716 within 0
IS/Tn 16249..16731 15243..15716 flank 533


Gene organization within MGE regions


Location: 12936..56047
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SanJ4206_RS00070 (SanJ4206_0014) ftsH 12936..14906 (+) 1971 WP_003029496.1 ATP-dependent zinc metalloprotease FtsH -
  SanJ4206_RS00075 (SanJ4206_0015) comR/comR2 15243..15716 (+) 474 WP_022525268.1 sigma-70 family RNA polymerase sigma factor Regulator
  SanJ4206_RS00080 - 15723..16731 (-) 1009 Protein_15 IS30 family transposase -
  SanJ4206_RS00195 (SanJ4206_0017) mreC 24031..24837 (+) 807 WP_003028741.1 rod shape-determining protein MreC -
  SanJ4206_RS00200 (SanJ4206_0018) mreD 24839..25339 (+) 501 WP_003028742.1 rod shape-determining protein MreD -
  SanJ4206_RS00205 (SanJ4206_0019) pcsB 25449..26672 (+) 1224 WP_003028745.1 peptidoglycan hydrolase PcsB -
  SanJ4206_RS00210 (SanJ4206_0020) - 26805..27773 (+) 969 WP_022525464.1 ribose-phosphate diphosphokinase -
  SanJ4206_RS00215 (SanJ4206_0021) - 27928..29115 (+) 1188 WP_003028750.1 pyridoxal phosphate-dependent aminotransferase -
  SanJ4206_RS00220 (SanJ4206_0022) recO 29093..29866 (+) 774 WP_003028752.1 DNA repair protein RecO -
  SanJ4206_RS00225 (SanJ4206_0023) plsX 29863..30861 (+) 999 WP_003028754.1 phosphate acyltransferase PlsX -
  SanJ4206_RS00230 (SanJ4206_0024) - 30858..31103 (+) 246 WP_003028756.1 acyl carrier protein -
  SanJ4206_RS00235 (SanJ4206_0025) purC 31263..31970 (+) 708 WP_003028757.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SanJ4206_RS00240 (SanJ4206_0026) - 32022..35747 (+) 3726 WP_003028759.1 phosphoribosylformylglycinamidine synthase -
  SanJ4206_RS00245 (SanJ4206_0027) purF 35838..37301 (+) 1464 WP_037582645.1 amidophosphoribosyltransferase -
  SanJ4206_RS00250 (SanJ4206_0028) purM 37537..38556 (+) 1020 WP_003028761.1 phosphoribosylformylglycinamidine cyclo-ligase -
  SanJ4206_RS00255 (SanJ4206_0029) purN 38556..39107 (+) 552 WP_003028762.1 phosphoribosylglycinamide formyltransferase -
  SanJ4206_RS00265 (SanJ4206_0031) purH 39337..40884 (+) 1548 WP_003028764.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  SanJ4206_RS00270 (SanJ4206_0032c) - 40943..42877 (-) 1935 WP_022525462.1 GBS Bsp-like repeat-containing protein -
  SanJ4206_RS00275 (SanJ4206_0033) - 43300..44679 (+) 1380 WP_003028768.1 Eco57I restriction-modification methylase domain-containing protein -
  SanJ4206_RS00280 (SanJ4206_0034) - 44690..47083 (+) 2394 WP_003028771.1 ATP-binding protein -
  SanJ4206_RS00285 (SanJ4206_0035) - 47085..47720 (+) 636 WP_022525486.1 hypothetical protein -
  SanJ4206_RS00290 (SanJ4206_0036) - 47720..48328 (+) 609 WP_003028777.1 HNH endonuclease signature motif containing protein -
  SanJ4206_RS00295 (SanJ4206_0037) - 48447..49310 (+) 864 WP_037607457.1 IS982 family transposase -
  SanJ4206_RS00305 (SanJ4206_0040) purD 51007..52272 (+) 1266 WP_003027967.1 phosphoribosylamine--glycine ligase -
  SanJ4206_RS00310 (SanJ4206_0041) - 52262..52696 (+) 435 WP_003027966.1 DUF523 domain-containing protein -
  SanJ4206_RS00315 (SanJ4206_0042) purE 52935..53423 (+) 489 WP_022525246.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  SanJ4206_RS00320 (SanJ4206_0043) purK 53410..54498 (+) 1089 WP_003027964.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  SanJ4206_RS00325 (SanJ4206_0044) - 54510..54731 (+) 222 WP_003027963.1 hypothetical protein -
  SanJ4206_RS00330 (SanJ4206_0045) - 54737..56047 (+) 1311 WP_003027962.1 RNA-directed DNA polymerase -

Sequence

Protein


Download         Length: 157 a.a.        Molecular weight: 19345.19 Da        Isoelectric Point: 7.3491

>NTDB_id=156742 SanJ4206_RS00075 WP_022525268.1 15243..15716(+) (comR/comR2) [Streptococcus anginosus strain J4206]
MEFKELYAKVRGIVLKCRREYYVHLWELSDWEQEGMLVLYQLVSRYPQLVEEDHQLYVYYKTKFRNHILDILRKQESQKR
KLDRQAYEEVSEIGHKLSLKELYLDELVILRDQLKSYQAQLSPEKQEQYERLLADERFKGRQAMIRELRAYLKDYSD

Nucleotide


Download         Length: 474 bp        

>NTDB_id=156742 SanJ4206_RS00075 WP_022525268.1 15243..15716(+) (comR/comR2) [Streptococcus anginosus strain J4206]
ATGGAGTTCAAGGAGTTATATGCCAAGGTGAGAGGAATTGTGCTGAAGTGTCGGAGGGAATATTATGTCCACCTGTGGGA
ATTAAGCGATTGGGAACAAGAGGGCATGTTGGTGCTCTATCAGTTGGTGAGTCGCTATCCGCAGCTAGTAGAAGAAGATC
ATCAGCTTTATGTTTACTATAAGACCAAGTTTCGTAATCATATCTTGGACATCCTCCGTAAGCAGGAAAGTCAAAAACGC
AAACTTGATCGTCAAGCTTATGAAGAAGTGAGCGAGATTGGTCACAAGCTCAGCCTAAAAGAACTATATCTGGATGAATT
GGTGATTCTCCGAGACCAGCTAAAGAGCTATCAAGCTCAACTGAGCCCAGAGAAACAGGAGCAGTACGAGCGCTTACTAG
CCGATGAACGGTTCAAAGGCCGCCAAGCCATGATTCGAGAATTAAGAGCCTACTTAAAGGACTATAGCGATTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

60.256

99.363

0.599
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

60.256

99.363

0.599
  comX/comX2 Streptococcus pneumoniae TIGR4

54.545

98.089

0.535
  comX/comX1 Streptococcus pneumoniae TIGR4

54.545

98.089

0.535
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

54.545

98.089

0.535
  comX/comX1 Streptococcus pneumoniae R6

53.896

98.089

0.529
  comX/comX2 Streptococcus pneumoniae D39

53.896

98.089

0.529
  comX/comX2 Streptococcus pneumoniae Rx1

53.896

98.089

0.529
  comX/comX1 Streptococcus pneumoniae Rx1

53.896

98.089

0.529
  comX/comX1 Streptococcus pneumoniae D39

53.896

98.089

0.529
  comX/comX2 Streptococcus pneumoniae R6

53.896

98.089

0.529
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

53.896

98.089

0.529
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

53.247

98.089

0.522
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

52.597

98.089

0.516
  comX/sigX Streptococcus mutans UA159

49.359

99.363

0.49
  comX/sigX Streptococcus suis D9

49.032

98.726

0.484
  comX/sigX Streptococcus suis isolate S10

49.032

98.726

0.484
  comX/sigX Streptococcus suis P1/7

49.032

98.726

0.484
  comX Streptococcus salivarius SK126

45.455

98.089

0.446
  comX/sigX Streptococcus salivarius strain HSISS4

44.805

98.089

0.439
  comX Streptococcus thermophilus LMG 18311

44.805

98.089

0.439
  comX Streptococcus thermophilus LMD-9

44.805

98.089

0.439
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

42.308

99.363

0.42
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

42.308

99.363

0.42
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

42.308

99.363

0.42
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

42.308

99.363

0.42
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

42.308

99.363

0.42
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

42.308

99.363

0.42
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

37.821

99.363

0.376
  comX Streptococcus sobrinus strain NIDR 6715-7

38.562

97.452

0.376

Multiple sequence alignment