Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR/comR2   Type   Regulator
Locus tag   DQM54_RS10695 Genome accession   NZ_LS483375
Coordinates   2136810..2137292 (-) Length   160 a.a.
NCBI ID   WP_045772576.1    Uniprot ID   A0A0F3HQT1
Organism   Streptococcus gordonii strain NCTC3165     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2106071..2139803 2136810..2137292 within 0


Gene organization within MGE regions


Location: 2106071..2139803
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM54_RS10450 (NCTC3165_02080) comA 2106071..2108224 (-) 2154 WP_111724245.1 peptide cleavage/export ABC transporter ComA Regulator
  DQM54_RS10455 (NCTC3165_02081) - 2108926..2109135 (-) 210 WP_111724246.1 hypothetical protein -
  DQM54_RS10465 (NCTC3165_02083) - 2109997..2110500 (-) 504 WP_111724247.1 hypothetical protein -
  DQM54_RS10470 (NCTC3165_02084) - 2110573..2111097 (-) 525 WP_111724248.1 hypothetical protein -
  DQM54_RS10475 (NCTC3165_02085) - 2111462..2112901 (-) 1440 WP_111724323.1 phage/plasmid primase, P4 family -
  DQM54_RS10480 (NCTC3165_02086) - 2112981..2113841 (-) 861 WP_111724249.1 primase alpha helix C-terminal domain-containing protein -
  DQM54_RS10485 (NCTC3165_02087) - 2113982..2114258 (-) 277 Protein_2012 XRE family transcriptional regulator -
  DQM54_RS10490 (NCTC3165_02088) - 2114251..2114592 (-) 342 WP_111724250.1 DNA-binding protein -
  DQM54_RS10495 (NCTC3165_02089) - 2114589..2114804 (-) 216 WP_111724251.1 hypothetical protein -
  DQM54_RS10500 (NCTC3165_02090) - 2114806..2115009 (-) 204 WP_111724252.1 hypothetical protein -
  DQM54_RS10505 (NCTC3165_02091) - 2115291..2115917 (-) 627 WP_111724253.1 Rha family transcriptional regulator -
  DQM54_RS10510 (NCTC3165_02092) - 2115932..2116129 (-) 198 WP_111724254.1 helix-turn-helix domain-containing protein -
  DQM54_RS10515 (NCTC3165_02093) - 2116293..2117066 (+) 774 WP_111724255.1 helix-turn-helix domain-containing protein -
  DQM54_RS10520 (NCTC3165_02094) - 2117110..2118099 (+) 990 WP_084849558.1 DUF3644 domain-containing protein -
  DQM54_RS10525 (NCTC3165_02095) - 2118445..2119611 (+) 1167 WP_111724256.1 tyrosine-type recombinase/integrase -
  DQM54_RS10530 (NCTC3165_02096) rpsD 2119700..2120311 (-) 612 WP_008810013.1 30S ribosomal protein S4 -
  DQM54_RS10535 (NCTC3165_02097) - 2120577..2121299 (-) 723 WP_111724257.1 ABC transporter ATP-binding protein -
  DQM54_RS10540 (NCTC3165_02098) - 2121299..2122300 (-) 1002 WP_111724258.1 ABC transporter substrate-binding protein -
  DQM54_RS10545 (NCTC3165_02099) - 2122341..2123093 (-) 753 WP_060554273.1 ABC transporter permease -
  DQM54_RS10550 (NCTC3165_02100) - 2123056..2123346 (-) 291 WP_045504760.1 MTH1187 family thiamine-binding protein -
  DQM54_RS10555 (NCTC3165_02102) - 2123686..2124345 (-) 660 WP_061597425.1 HAD family hydrolase -
  DQM54_RS10560 (NCTC3165_02103) srtB 2124424..2125281 (-) 858 WP_045504765.1 class B sortase, LPKTxAVK-specific -
  DQM54_RS10565 (NCTC3165_02104) abpA 2125369..2125956 (-) 588 WP_045504766.1 amylase-binding adhesin AbpA -
  DQM54_RS10570 (NCTC3165_02105) - 2126173..2127138 (-) 966 WP_111724259.1 ribose-phosphate diphosphokinase -
  DQM54_RS10575 (NCTC3165_02106) pcsB 2127298..2128488 (-) 1191 WP_111724260.1 peptidoglycan hydrolase PcsB -
  DQM54_RS10580 (NCTC3165_02107) mreD 2128588..2129088 (-) 501 WP_111724261.1 rod shape-determining protein MreD -
  DQM54_RS10585 (NCTC3165_02108) mreC 2129090..2129905 (-) 816 WP_111724262.1 rod shape-determining protein MreC -
  DQM54_RS10695 (NCTC3165_02130) comR/comR2 2136810..2137292 (-) 483 WP_045772576.1 sigma-70 family RNA polymerase sigma factor Regulator
  DQM54_RS10710 (NCTC3165_02133) ftsH 2137821..2139803 (-) 1983 WP_046164766.1 ATP-dependent zinc metalloprotease FtsH -

Sequence

Protein


Download         Length: 160 a.a.        Molecular weight: 19931.87 Da        Isoelectric Point: 9.4703

>NTDB_id=1139162 DQM54_RS10695 WP_045772576.1 2136810..2137292(-) (comR/comR2) [Streptococcus gordonii strain NCTC3165]
MKFEDVYKQVEGIVKRCYKDYYLHLWEYADWRQEGMLVLYELLKSHPNLLEDHPRLYRYFKTKFRNRIHDLIRRQESQKR
KLDRQPYEEVSEIGHRLRMKELYLDELVAFRSAMAEYRSQLSPEESKQYERLMADERFKGRKAMLKDLSYHLRDFNPRLD

Nucleotide


Download         Length: 483 bp        

>NTDB_id=1139162 DQM54_RS10695 WP_045772576.1 2136810..2137292(-) (comR/comR2) [Streptococcus gordonii strain NCTC3165]
ATGAAGTTTGAGGACGTATACAAACAAGTTGAAGGGATAGTCAAGCGCTGTTATAAAGATTATTATCTGCACTTATGGGA
GTATGCAGATTGGAGGCAGGAAGGAATGTTGGTGTTGTACGAATTATTAAAAAGTCATCCCAACCTACTGGAAGATCATC
CACGCCTGTACCGTTACTTCAAGACCAAGTTTCGGAACAGAATTCATGATTTGATTCGTCGCCAAGAGAGTCAAAAGCGG
AAATTGGACAGGCAACCCTATGAAGAGGTCAGCGAGATAGGTCATCGTTTAAGAATGAAAGAGCTGTATCTGGATGAATT
GGTAGCTTTTAGAAGTGCAATGGCAGAGTATAGAAGTCAGCTCAGTCCAGAAGAATCAAAACAATATGAGCGCCTGATGG
CAGATGAAAGATTCAAAGGACGTAAGGCAATGCTCAAAGATTTGTCCTATCACTTAAGGGATTTCAATCCCCGTTTAGAT
TAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F3HQT1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

97.5

100

0.975
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

97.5

100

0.975
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

50

97.5

0.488
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

49.359

97.5

0.481
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

49.359

97.5

0.481
  comX/comX1 Streptococcus pneumoniae Rx1

48.718

97.5

0.475
  comX/comX2 Streptococcus pneumoniae D39

48.718

97.5

0.475
  comX/comX1 Streptococcus pneumoniae D39

48.718

97.5

0.475
  comX/comX2 Streptococcus pneumoniae R6

48.718

97.5

0.475
  comX/comX1 Streptococcus pneumoniae R6

48.718

97.5

0.475
  comX/comX1 Streptococcus pneumoniae TIGR4

48.718

97.5

0.475
  comX/comX2 Streptococcus pneumoniae Rx1

48.718

97.5

0.475
  comX/comX2 Streptococcus pneumoniae TIGR4

48.718

97.5

0.475
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

48.077

97.5

0.469
  comX/sigX Streptococcus suis P1/7

48.387

96.875

0.469
  comX/sigX Streptococcus suis D9

48.387

96.875

0.469
  comX/sigX Streptococcus suis isolate S10

48.387

96.875

0.469
  comX/sigX Streptococcus mutans UA159

47.436

97.5

0.463
  comX Streptococcus thermophilus LMG 18311

43.871

96.875

0.425
  comX Streptococcus thermophilus LMD-9

43.871

96.875

0.425
  comX/sigX Streptococcus salivarius strain HSISS4

43.226

96.875

0.419
  comX Streptococcus salivarius SK126

43.226

96.875

0.419
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

42.208

96.25

0.406
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

42.208

96.25

0.406
  comX Streptococcus sobrinus strain NIDR 6715-7

42.208

96.25

0.406
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

40.506

98.75

0.4
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

41.558

96.25

0.4
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

41.558

96.25

0.4
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

41.558

96.25

0.4
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

41.558

96.25

0.4

Multiple sequence alignment