Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/sigX   Type   Regulator
Locus tag   FGL16_RS00080 Genome accession   NZ_LR594043
Coordinates   15940..16410 (+) Length   156 a.a.
NCBI ID   WP_014735269.1    Uniprot ID   -
Organism   Streptococcus suis strain NCTC10237     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 13614..61952 15940..16410 within 0


Gene organization within MGE regions


Location: 13614..61952
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL16_RS00075 (NCTC10237_00014) ftsH 13614..15584 (+) 1971 WP_014735204.1 ATP-dependent zinc metalloprotease FtsH -
  FGL16_RS00080 (NCTC10237_00015) comX/sigX 15940..16410 (+) 471 WP_014735269.1 sigma-70 family RNA polymerase sigma factor Regulator
  FGL16_RS00190 (NCTC10237_00036) mreC 23704..24540 (+) 837 WP_014735206.1 rod shape-determining protein MreC -
  FGL16_RS00195 (NCTC10237_00037) mreD 24542..25045 (+) 504 WP_228380208.1 rod shape-determining protein MreD -
  FGL16_RS00200 (NCTC10237_00038) - 25130..26386 (+) 1257 WP_014735207.1 CHAP domain-containing protein -
  FGL16_RS00205 (NCTC10237_00039) - 26451..27677 (-) 1227 WP_197733566.1 ISL3 family transposase -
  FGL16_RS00210 (NCTC10237_00040) - 27911..28879 (+) 969 WP_014735209.1 ribose-phosphate diphosphokinase -
  FGL16_RS00215 (NCTC10237_00041) - 28966..30144 (+) 1179 WP_014735210.1 pyridoxal phosphate-dependent aminotransferase -
  FGL16_RS00220 (NCTC10237_00042) recO 30131..30913 (+) 783 WP_014735211.1 DNA repair protein RecO -
  FGL16_RS00225 (NCTC10237_00043) plsX 30910..31917 (+) 1008 WP_014735212.1 phosphate acyltransferase PlsX -
  FGL16_RS00230 (NCTC10237_00044) - 31910..32158 (+) 249 WP_014637254.1 phosphopantetheine-binding protein -
  FGL16_RS00235 tnpA 32329..32792 (+) 464 Protein_25 IS200/IS605-like element ISSsu4 family transposase -
  FGL16_RS00245 (NCTC10237_00047) purC 33031..33738 (+) 708 WP_014735214.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  FGL16_RS00250 (NCTC10237_00048) - 33751..37470 (+) 3720 WP_024405312.1 phosphoribosylformylglycinamidine synthase -
  FGL16_RS00255 (NCTC10237_00049) purF 37473..38927 (+) 1455 WP_014735216.1 amidophosphoribosyltransferase -
  FGL16_RS00265 tnpA 39132..39645 (-) 514 Protein_29 IS200/IS605 family transposase -
  FGL16_RS00270 (NCTC10237_00051) purM 39792..40811 (+) 1020 WP_024405246.1 phosphoribosylformylglycinamidine cyclo-ligase -
  FGL16_RS00275 (NCTC10237_00052) purN 40808..41359 (+) 552 WP_014735219.1 phosphoribosylglycinamide formyltransferase -
  FGL16_RS00280 (NCTC10237_00053) purH 41369..42916 (+) 1548 WP_014735220.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  FGL16_RS00285 (NCTC10237_00054) - 43015..43866 (+) 852 WP_014735221.1 hypothetical protein -
  FGL16_RS00290 (NCTC10237_00055) purD 44001..45266 (+) 1266 WP_014735222.1 phosphoribosylamine--glycine ligase -
  FGL16_RS00295 (NCTC10237_00056) - 45256..45702 (+) 447 WP_014735223.1 DUF523 domain-containing protein -
  FGL16_RS00300 (NCTC10237_00057) purE 45699..46187 (+) 489 WP_014735224.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  FGL16_RS00305 (NCTC10237_00058) purK 46174..47268 (+) 1095 WP_014735225.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  FGL16_RS00310 (NCTC10237_00059) - 47283..49805 (+) 2523 WP_014735226.1 DEAD/DEAH box helicase -
  FGL16_RS00315 (NCTC10237_00060) purB 50200..51492 (+) 1293 WP_014735227.1 adenylosuccinate lyase -
  FGL16_RS00320 (NCTC10237_00061) tnpA 51683..52147 (+) 465 WP_002939996.1 IS200/IS605-like element ISSsu4 family transposase -
  FGL16_RS00330 (NCTC10237_00062) - 52571..53395 (+) 825 WP_014735229.1 ABC transporter ATP-binding protein -
  FGL16_RS00335 (NCTC10237_00063) - 53388..54131 (+) 744 WP_014735230.1 ABC transporter permease -
  FGL16_RS00340 (NCTC10237_00064) - 54457..55185 (+) 729 WP_014735232.1 hypothetical protein -
  FGL16_RS00345 (NCTC10237_00066) - 55195..55773 (+) 579 Protein_44 CPBP family intramembrane glutamic endopeptidase -
  FGL16_RS00350 (NCTC10237_00067) - 55788..56216 (+) 429 WP_024405339.1 Msa family membrane protein -
  FGL16_RS00355 (NCTC10237_00068) - 56209..57081 (+) 873 WP_014735236.1 ABC transporter ATP-binding protein -
  FGL16_RS00360 (NCTC10237_00069) - 57087..57861 (+) 775 Protein_47 hypothetical protein -
  FGL16_RS00370 tnpA 58129..58642 (+) 514 Protein_48 IS200/IS605 family transposase -
  FGL16_RS00380 (NCTC10237_00071) - 58780..60381 (+) 1602 WP_014735239.1 ABC transporter ATP-binding protein -
  FGL16_RS10890 (NCTC10237_00072) - 60483..60656 (+) 174 WP_014735240.1 hypothetical protein -
  FGL16_RS00385 (NCTC10237_00073) ruvB 60951..61952 (+) 1002 WP_014735241.1 Holliday junction branch migration DNA helicase RuvB -

Sequence

Protein


Download         Length: 156 a.a.        Molecular weight: 19043.97 Da        Isoelectric Point: 9.2926

>NTDB_id=1127603 FGL16_RS00080 WP_014735269.1 15940..16410(+) (comX/sigX) [Streptococcus suis strain NCTC10237]
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKR
KFDRMPHEDIHELSHAIQSPGLINDELLMLRGALRDYQKNLSNDQLDKYEKLISGQCFNGRRKMIRDLQIHLKDFR

Nucleotide


Download         Length: 471 bp        

>NTDB_id=1127603 FGL16_RS00080 WP_014735269.1 15940..16410(+) (comX/sigX) [Streptococcus suis strain NCTC10237]
ATGGAATTCGAAAAAGTGTACGCAAGCGTCAAAGGTATTGTAAACAAGGCTCGAAAAGAGTTTTACATTAAACTATGGGA
TCGAGATGATTGGGAACAAGAAGGAATGATGACCTTGTTTGAATTATTGGAAGCTCAACCGTGGCTAGTTGATGAACAAG
TTCAATTATATTGTTATTTTAAAGTCAAGTTCAGAAATCGAATCAAGGATCGTATCCGCAAACAGGAAAGTCAAAAACGC
AAGTTTGACCGTATGCCACATGAAGATATTCACGAATTATCTCACGCAATACAATCACCGGGATTGATAAACGATGAACT
ATTAATGCTAAGAGGTGCCTTGAGAGATTATCAAAAAAATCTGAGTAATGATCAACTTGATAAATATGAAAAATTAATTA
GCGGACAATGTTTTAATGGTCGCCGTAAAATGATACGTGATTTACAAATTCATTTGAAAGACTTTCGCTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/sigX Streptococcus suis D9

98.718

100

0.987
  comX/sigX Streptococcus suis isolate S10

98.077

100

0.981
  comX/sigX Streptococcus suis P1/7

98.077

100

0.981
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

48.387

99.359

0.481
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

48.387

99.359

0.481
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

45.098

98.077

0.442
  comX/comX2 Streptococcus pneumoniae TIGR4

45.695

96.795

0.442
  comX/comX1 Streptococcus pneumoniae TIGR4

45.695

96.795

0.442
  comX/comX2 Streptococcus pneumoniae R6

45.033

96.795

0.436
  comX/comX2 Streptococcus pneumoniae Rx1

45.033

96.795

0.436
  comX/comX1 Streptococcus pneumoniae Rx1

45.033

96.795

0.436
  comX/comX2 Streptococcus pneumoniae D39

45.033

96.795

0.436
  comX/comX1 Streptococcus pneumoniae D39

45.033

96.795

0.436
  comX/comX1 Streptococcus pneumoniae R6

45.033

96.795

0.436
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

44.444

98.077

0.436
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

44.444

98.077

0.436
  comX/sigX Streptococcus mutans UA159

43.226

99.359

0.429
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

43.791

98.077

0.429
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

40.645

99.359

0.404
  comX Streptococcus sobrinus strain NIDR 6715-7

40.523

98.077

0.397
  comX Streptococcus thermophilus LMG 18311

40.523

98.077

0.397
  comX Streptococcus thermophilus LMD-9

40.523

98.077

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

99.359

0.397
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

99.359

0.397
  comX Streptococcus salivarius SK126

39.869

98.077

0.391
  comX/sigX Streptococcus salivarius strain HSISS4

39.869

98.077

0.391
  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.217

100

0.385

Multiple sequence alignment