Detailed information    

insolico Bioinformatically predicted

Overview


Name   comR/comR2   Type   Regulator
Locus tag   ABKA15_RS09275 Genome accession   NZ_CP157941
Coordinates   1868447..1868920 (-) Length   157 a.a.
NCBI ID   WP_192208621.1    Uniprot ID   A0A7L8W6X1
Organism   Streptococcus sp. KHUD_010     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1840474..1883376 1868447..1868920 within 0


Gene organization within MGE regions


Location: 1840474..1883376
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABKA15_RS09070 (ABKA15_09060) - 1840474..1841493 (+) 1020 WP_192208559.1 IS30 family transposase -
  ABKA15_RS09075 (ABKA15_09065) - 1841505..1841747 (-) 243 WP_049514295.1 hypothetical protein -
  ABKA15_RS09080 (ABKA15_09070) - 1841777..1841992 (-) 216 WP_049514293.1 hypothetical protein -
  ABKA15_RS09085 (ABKA15_09075) - 1842349..1844283 (+) 1935 WP_049514291.1 GBS Bsp-like repeat-containing protein -
  ABKA15_RS09090 (ABKA15_09080) purH 1844342..1845889 (-) 1548 WP_049514289.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  ABKA15_RS09095 (ABKA15_09085) - 1845897..1846064 (-) 168 WP_350015350.1 phosphoribosylaminoimidazolecarboxamide formyltransferase -
  ABKA15_RS09100 (ABKA15_09090) purN 1846116..1846667 (-) 552 WP_049514285.1 phosphoribosylglycinamide formyltransferase -
  ABKA15_RS09105 (ABKA15_09095) purM 1846667..1847686 (-) 1020 WP_049514284.1 phosphoribosylformylglycinamidine cyclo-ligase -
  ABKA15_RS09110 (ABKA15_09100) purF 1847922..1849385 (-) 1464 WP_049514282.1 amidophosphoribosyltransferase -
  ABKA15_RS09115 (ABKA15_09105) - 1849476..1853201 (-) 3726 WP_186832633.1 phosphoribosylformylglycinamidine synthase -
  ABKA15_RS09120 (ABKA15_09110) purC 1853248..1853955 (-) 708 WP_186832632.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  ABKA15_RS09125 (ABKA15_09115) - 1854115..1854360 (-) 246 WP_186832631.1 acyl carrier protein -
  ABKA15_RS09130 (ABKA15_09120) plsX 1854357..1855355 (-) 999 WP_186832630.1 phosphate acyltransferase PlsX -
  ABKA15_RS09135 (ABKA15_09125) recO 1855352..1856125 (-) 774 WP_186832629.1 DNA repair protein RecO -
  ABKA15_RS09140 (ABKA15_09130) - 1856103..1857290 (-) 1188 WP_049533227.1 pyridoxal phosphate-dependent aminotransferase -
  ABKA15_RS09145 (ABKA15_09135) - 1857445..1858413 (-) 969 WP_003027164.1 ribose-phosphate diphosphokinase -
  ABKA15_RS09150 (ABKA15_09140) - 1858546..1859766 (-) 1221 WP_186832628.1 CHAP domain-containing protein -
  ABKA15_RS09155 (ABKA15_09145) mreD 1859876..1860376 (-) 501 WP_106387792.1 rod shape-determining protein MreD -
  ABKA15_RS09160 (ABKA15_09150) mreC 1860378..1861184 (-) 807 WP_186832627.1 rod shape-determining protein MreC -
  ABKA15_RS09275 (ABKA15_09265) comR/comR2 1868447..1868920 (-) 474 WP_192208621.1 sigma-70 family RNA polymerase sigma factor Regulator
  ABKA15_RS09280 (ABKA15_09270) ftsH 1869125..1871095 (-) 1971 WP_186832585.1 ATP-dependent zinc metalloprotease FtsH -
  ABKA15_RS09285 (ABKA15_09275) hpt 1871116..1871658 (-) 543 WP_049512741.1 hypoxanthine phosphoribosyltransferase -
  ABKA15_RS09290 (ABKA15_09280) tilS 1871664..1872941 (-) 1278 WP_049512740.1 tRNA lysidine(34) synthetase TilS -
  ABKA15_RS09295 (ABKA15_09285) - 1872938..1874218 (-) 1281 WP_049512737.1 serine hydrolase -
  ABKA15_RS09300 (ABKA15_09290) - 1874211..1874339 (-) 129 WP_152907026.1 SP_0009 family protein -
  ABKA15_RS09305 (ABKA15_09295) - 1874342..1874710 (-) 369 WP_003026832.1 septum formation initiator family protein -
  ABKA15_RS09310 (ABKA15_09300) - 1874703..1874969 (-) 267 WP_049512735.1 RNA-binding S4 domain-containing protein -
  ABKA15_RS09315 (ABKA15_09305) mfd 1875049..1878555 (-) 3507 WP_152907025.1 transcription-repair coupling factor -
  ABKA15_RS09320 (ABKA15_09310) pth 1878548..1879117 (-) 570 WP_003032454.1 aminoacyl-tRNA hydrolase -
  ABKA15_RS09325 (ABKA15_09315) ychF 1879190..1880305 (-) 1116 WP_049512731.1 redox-regulated ATPase YchF -
  ABKA15_RS09330 (ABKA15_09320) - 1880451..1880951 (+) 501 WP_049512729.1 YehR family protein -
  ABKA15_RS09335 (ABKA15_09325) - 1880975..1881172 (-) 198 WP_049512728.1 DUF951 family protein -
  ABKA15_RS09340 (ABKA15_09330) dnaN 1881172..1882308 (-) 1137 WP_049512726.1 DNA polymerase III subunit beta -

Sequence


Protein


Download         Length: 157 a.a.        Molecular weight: 19253.09 Da        Isoelectric Point: 7.9719

>NTDB_id=1009145 ABKA15_RS09275 WP_192208621.1 1868447..1868920(-) (comR/comR2) [Streptococcus sp. KHUD_010]
MEFKELYGKVRGIVLKCRREYYVHLWELSDWDQEGMLVLYQLVSRYPQLVETESQLYVYYKTKFRNHILDILRKQESQKR
KLDRQAYEEVSEIGHKLSLKELYLDELVILRDQLKSYQAQLSPEKQEQYERLLADERFKGRQAMIRELRAYLKDYSD

Nucleotide


Download         Length: 474 bp        

>NTDB_id=1009145 ABKA15_RS09275 WP_192208621.1 1868447..1868920(-) (comR/comR2) [Streptococcus sp. KHUD_010]
ATGGAGTTCAAGGAGTTGTATGGGAAGGTAAGGGGGATTGTATTAAAGTGCCGTCGGGAATATTATGTCCACCTGTGGGA
ATTAAGCGATTGGGACCAAGAGGGCATGTTAGTACTCTATCAGTTGGTAAGTCGCTATCCGCAGCTGGTAGAGACAGAAA
GTCAGCTCTATGTTTACTATAAGACCAAGTTCCGCAATCATATCCTGGACATCCTCCGTAAACAGGAAAGCCAAAAACGC
AAACTCGATCGTCAAGCTTATGAAGAAGTGAGCGAGATAGGTCACAAGCTCAGCCTGAAAGAGTTGTATCTGGATGAATT
GGTGATTCTCCGAGACCAGCTAAAGAGCTATCAAGCTCAACTGAGTCCAGAGAAACAAGAGCAGTACGAGCGCTTACTAG
CTGATGAACGTTTCAAAGGCCGCCAAGCCATGATTCGAGAATTAAGAGCCTACTTAAAGGACTATAGCGATTAA

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A7L8W6X1

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

60.256

99.363

0.599

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

60.256

99.363

0.599

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

55.195

98.089

0.541

  comX/comX2 Streptococcus pneumoniae D39

54.545

98.089

0.535

  comX/comX1 Streptococcus pneumoniae D39

54.545

98.089

0.535

  comX/comX1 Streptococcus pneumoniae R6

54.545

98.089

0.535

  comX/comX2 Streptococcus pneumoniae R6

54.545

98.089

0.535

  comX/comX2 Streptococcus pneumoniae Rx1

54.545

98.089

0.535

  comX/comX1 Streptococcus pneumoniae Rx1

54.545

98.089

0.535

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

54.545

98.089

0.535

  comX/comX2 Streptococcus pneumoniae TIGR4

53.896

98.089

0.529

  comX/comX1 Streptococcus pneumoniae TIGR4

53.896

98.089

0.529

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

53.896

98.089

0.529

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

53.247

98.089

0.522

  comX/sigX Streptococcus mutans UA159

48.718

99.363

0.484

  comX/sigX Streptococcus suis D9

47.097

98.726

0.465

  comX/sigX Streptococcus suis isolate S10

47.097

98.726

0.465

  comX/sigX Streptococcus suis P1/7

47.097

98.726

0.465

  comX Streptococcus salivarius SK126

44.156

98.089

0.433

  comX/sigX Streptococcus salivarius strain HSISS4

43.506

98.089

0.427

  comX Streptococcus thermophilus LMG 18311

43.506

98.089

0.427

  comX Streptococcus thermophilus LMD-9

43.506

98.089

0.427

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

42.308

99.363

0.42

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

42.308

99.363

0.42

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

42.308

99.363

0.42

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

42.308

99.363

0.42

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

42.308

99.363

0.42

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

42.308

99.363

0.42

  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

38.462

99.363

0.382

  comX Streptococcus sobrinus strain NIDR 6715-7

39.216

97.452

0.382


Multiple sequence alignment