Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2345534..2346189 Replicon chromosome
Accession NC_009085
Organism Acinetobacter baumannii ATCC 17978

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A1S_2020 Protein ID YP_001085049.1
Coordinates 2346031..2346189 (-) Length 53 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A1S_2019 Protein ID YP_001085048.1
Coordinates 2345534..2345968 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1S_2019 2345534..2345968 - 435 YP_001085048.1 hypothetical protein Antitoxin
A1S_2020 2346031..2346189 - 159 YP_001085049.1 hypothetical protein Toxin
A1S_2021 2347124..2347900 - 777 YP_001085050.1 hypothetical protein -
A1S_2022 2348094..2349194 - 1101 YP_001085051.1 tail fiber -
A1S_2023 2350572..2350982 - 411 YP_001085052.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2330900..2386278 55378


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-51)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(13-136)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5798.71 Da        Isoelectric Point: 10.4850

>T3593 YP_001085049.1 NC_009085:c2346189-2346031 [Acinetobacter baumannii ATCC 17978]
MIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 159 bp

>T3593 NC_009085:c2346189-2346031 [Acinetobacter baumannii ATCC 17978]
ATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTTTAAACACCCAACCAAAAAGGGGTT
AGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTTTGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 15883.18 Da        Isoelectric Point: 4.4596

>AT3593 YP_001085048.1 NC_009085:c2345968-2345534 [Acinetobacter baumannii ATCC 17978]
MFMPRAWSVEMLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDD
PEYKGMIWAVTEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 435 bp

>AT3593 NC_009085:c2345968-2345534 [Acinetobacter baumannii ATCC 17978]
ATGTTTATGCCAAGGGCATGGAGTGTTGAGATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGG
TGTCACTGTTCCTGATATTCCAGGTTGTTTTAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTA
TTTCAGGCCATTTAGAAATATTGGCTGAAGATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGAT
CCTGAATATAAAGGAATGATCTGGGCGGTTACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGT
TACTTTACCAAGCCGTTTGATTCGTAAAATTGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCT
TGGCTGCTGGTGCTGAAAAACTTTTACATGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
T6107 Burkholderia pseudomallei K96243

78.431

98.077

0.769
T875 Sinorhizobium meliloti 1021

62.745

98.077

0.615
T1325 Thermotoga maritima MSB8

35.417

92.308

0.327
T1039 Escherichia coli str. K-12 substr. MG1655

31.481

100

0.327
T10189 Escherichia coli strain DH5alpha

31.481

100

0.327
T10122 Paracoccus phage vB_PbeS_Pben1

33.333

91.111

0.304

Multiple sequence alignment    


Protein Organism Identities (%) Coverage (%) Ha-value
AT6107 Burkholderia pseudomallei K96243

45.522

97.101

0.442

Multiple sequence alignment    




Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References

(1) Shruti Kashyap et al. (2022) Tobramycin Stress Induced Differential Gene Expression in Acinetobacter baumannii. Current Microbiology 79(3):88. [PubMed:35129693] experimental


experimental experimental literature