265361

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1780644..1781323 Replicon chromosome
Accession NZ_CP113074
Organism Acinetobacter baumannii strain ATCC17978 TnAraC-H0N27_12600

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag OSH15_RS08525 Protein ID WP_000838146.1
Coordinates 1780644..1780826 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag OSH15_RS08530 Protein ID WP_000966688.1
Coordinates 1780919..1781323 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSH15_RS08490 (OSH15_08495) 1775887..1776285 + 399 WP_001251846.1 phage tail terminator-like protein -
OSH15_RS08495 (OSH15_08500) 1776287..1776505 + 219 WP_001277696.1 hypothetical protein -
OSH15_RS08500 (OSH15_08505) 1776614..1777135 + 522 WP_000749906.1 SH3 domain-containing protein -
OSH15_RS08505 (OSH15_08510) 1777232..1777585 + 354 WP_000064603.1 hypothetical protein -
OSH15_RS08510 (OSH15_08515) 1777585..1778763 + 1179 WP_000002414.1 hypothetical protein -
OSH15_RS08515 (OSH15_08520) 1778816..1779733 + 918 WP_000094261.1 phage tail tube protein -
OSH15_RS08520 (OSH15_08525) 1779803..1780318 + 516 WP_001185604.1 hypothetical protein -
OSH15_RS08525 (OSH15_08530) 1780644..1780826 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
OSH15_RS08530 (OSH15_08535) 1780919..1781323 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OSH15_RS08535 (OSH15_08540) 1781423..1781599 + 177 WP_074031683.1 hypothetical protein -
OSH15_RS08540 (OSH15_08545) 1781608..1781931 + 324 WP_000523932.1 DUF4236 domain-containing protein -
OSH15_RS08545 (OSH15_08550) 1781965..1782354 + 390 WP_031977960.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1746620..1795958 49338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T265361 WP_000838146.1 NZ_CP113074:1780644-1780826 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT265361 WP_000966688.1 NZ_CP113074:1780919-1781323 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References