Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3763663..3764342 Replicon chromosome
Accession NZ_CP018664
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag AUO97_RS18050 Protein ID WP_000838146.1
Coordinates 3764160..3764342 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag AUO97_RS18045 Protein ID WP_000966688.1
Coordinates 3763663..3764067 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUO97_RS18030 (AUO97_18030) 3762632..3763021 - 390 WP_031977960.1 hypothetical protein -
AUO97_RS18035 (AUO97_18035) 3763055..3763378 - 324 WP_000523932.1 DUF4236 domain-containing protein -
AUO97_RS18040 (AUO97_18040) 3763387..3763563 - 177 WP_074031683.1 hypothetical protein -
AUO97_RS18045 (AUO97_18045) 3763663..3764067 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AUO97_RS18050 (AUO97_18050) 3764160..3764342 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
AUO97_RS18060 (AUO97_18060) 3764668..3765183 - 516 WP_001185604.1 hypothetical protein -
AUO97_RS18065 (AUO97_18065) 3765253..3766170 - 918 WP_000094261.1 hypothetical protein -
AUO97_RS18070 (AUO97_18070) 3766223..3767401 - 1179 WP_000002414.1 hypothetical protein -
AUO97_RS18075 (AUO97_18075) 3767401..3767754 - 354 WP_000064603.1 hypothetical protein -
AUO97_RS18080 (AUO97_18080) 3767851..3768372 - 522 WP_000749906.1 SH3 domain-containing protein -
AUO97_RS18085 (AUO97_18085) 3768481..3768699 - 219 WP_001277696.1 hypothetical protein -
AUO97_RS18090 (AUO97_18090) 3768701..3769099 - 399 WP_001251846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3749028..3798366 49338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T70152 WP_000838146.1 NZ_CP018664:c3764342-3764160 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T70152 NZ_CP018664:c3764342-3764160 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT70152 WP_000966688.1 NZ_CP018664:c3764067-3763663 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT70152 NZ_CP018664:c3764067-3763663 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References