Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1623958..1624637 Replicon chromosome
Accession NZ_CP033108
Organism Acinetobacter baumannii ATCC 17978

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag EAE94_RS07705 Protein ID WP_000838146.1
Coordinates 1623958..1624140 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag EAE94_RS07710 Protein ID WP_000966688.1
Coordinates 1624233..1624637 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAE94_RS07670 (EAE94_07690) 1619201..1619599 + 399 WP_001251846.1 phage tail terminator-like protein -
EAE94_RS07675 (EAE94_07695) 1619601..1619819 + 219 WP_001277696.1 hypothetical protein -
EAE94_RS07680 (EAE94_07700) 1619928..1620449 + 522 WP_000749906.1 SH3 domain-containing protein -
EAE94_RS07685 (EAE94_07705) 1620546..1620899 + 354 WP_000064603.1 hypothetical protein -
EAE94_RS07690 (EAE94_07710) 1620899..1622077 + 1179 WP_000002414.1 hypothetical protein -
EAE94_RS07695 (EAE94_07715) 1622130..1623047 + 918 WP_000094261.1 phage tail tube protein -
EAE94_RS07700 (EAE94_07720) 1623117..1623632 + 516 WP_001185604.1 hypothetical protein -
EAE94_RS07705 (EAE94_07730) 1623958..1624140 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
EAE94_RS07710 (EAE94_07735) 1624233..1624637 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EAE94_RS07715 (EAE94_07740) 1624737..1624913 + 177 WP_074031683.1 hypothetical protein -
EAE94_RS07720 (EAE94_07745) 1624922..1625245 + 324 WP_000523932.1 DUF4236 domain-containing protein -
EAE94_RS07725 (EAE94_07750) 1625279..1625668 + 390 WP_031977960.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1592422..1639272 46850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T113183 WP_000838146.1 NZ_CP033108:1623958-1624140 [Acinetobacter baumannii ATCC 17978]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T113183 NZ_CP033108:1623958-1624140 [Acinetobacter baumannii ATCC 17978]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT113183 WP_000966688.1 NZ_CP033108:1624233-1624637 [Acinetobacter baumannii ATCC 17978]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT113183 NZ_CP033108:1624233-1624637 [Acinetobacter baumannii ATCC 17978]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References