Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1623958..1624637 | Replicon | chromosome |
Accession | NZ_CP033108 | ||
Organism | Acinetobacter baumannii ATCC 17978 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | S3TWT7 |
Locus tag | EAE94_RS07705 | Protein ID | WP_000838146.1 |
Coordinates | 1623958..1624140 (+) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | N9L2H6 |
Locus tag | EAE94_RS07710 | Protein ID | WP_000966688.1 |
Coordinates | 1624233..1624637 (+) | Length | 135 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EAE94_RS07670 (EAE94_07690) | 1619201..1619599 | + | 399 | WP_001251846.1 | phage tail terminator-like protein | - |
EAE94_RS07675 (EAE94_07695) | 1619601..1619819 | + | 219 | WP_001277696.1 | hypothetical protein | - |
EAE94_RS07680 (EAE94_07700) | 1619928..1620449 | + | 522 | WP_000749906.1 | SH3 domain-containing protein | - |
EAE94_RS07685 (EAE94_07705) | 1620546..1620899 | + | 354 | WP_000064603.1 | hypothetical protein | - |
EAE94_RS07690 (EAE94_07710) | 1620899..1622077 | + | 1179 | WP_000002414.1 | hypothetical protein | - |
EAE94_RS07695 (EAE94_07715) | 1622130..1623047 | + | 918 | WP_000094261.1 | phage tail tube protein | - |
EAE94_RS07700 (EAE94_07720) | 1623117..1623632 | + | 516 | WP_001185604.1 | hypothetical protein | - |
EAE94_RS07705 (EAE94_07730) | 1623958..1624140 | + | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
EAE94_RS07710 (EAE94_07735) | 1624233..1624637 | + | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
EAE94_RS07715 (EAE94_07740) | 1624737..1624913 | + | 177 | WP_074031683.1 | hypothetical protein | - |
EAE94_RS07720 (EAE94_07745) | 1624922..1625245 | + | 324 | WP_000523932.1 | DUF4236 domain-containing protein | - |
EAE94_RS07725 (EAE94_07750) | 1625279..1625668 | + | 390 | WP_031977960.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1592422..1639272 | 46850 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T113183 WP_000838146.1 NZ_CP033108:1623958-1624140 [Acinetobacter baumannii ATCC 17978]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T113183 NZ_CP033108:1623958-1624140 [Acinetobacter baumannii ATCC 17978]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT113183 WP_000966688.1 NZ_CP033108:1624233-1624637 [Acinetobacter baumannii ATCC 17978]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT113183 NZ_CP033108:1624233-1624637 [Acinetobacter baumannii ATCC 17978]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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