Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2223968..2224647 Replicon chromosome
Accession NZ_CP053098
Organism Acinetobacter baumannii ATCC 17978

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag HKO16_RS10610 Protein ID WP_000838146.1
Coordinates 2224465..2224647 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag HKO16_RS10605 Protein ID WP_000966688.1
Coordinates 2223968..2224372 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKO16_RS10590 2222937..2223326 - 390 WP_031977960.1 hypothetical protein -
HKO16_RS10595 2223360..2223683 - 324 WP_000523932.1 DUF4236 domain-containing protein -
HKO16_RS10600 2223692..2223868 - 177 WP_074031683.1 hypothetical protein -
HKO16_RS10605 2223968..2224372 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKO16_RS10610 2224465..2224647 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
HKO16_RS10615 2224973..2225488 - 516 WP_001185604.1 hypothetical protein -
HKO16_RS10620 2225558..2226475 - 918 WP_000094261.1 hypothetical protein -
HKO16_RS10625 2226528..2227706 - 1179 WP_000002414.1 hypothetical protein -
HKO16_RS10630 2227706..2228059 - 354 WP_000064603.1 hypothetical protein -
HKO16_RS10635 2228156..2228677 - 522 WP_000749906.1 SH3 domain-containing protein -
HKO16_RS10640 2228786..2229004 - 219 WP_001277696.1 hypothetical protein -
HKO16_RS10645 2229006..2229404 - 399 WP_001251846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2209333..2264716 55383


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T156085 WP_000838146.1 NZ_CP053098:c2224647-2224465 [Acinetobacter baumannii ATCC 17978]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T156085 NZ_CP068826:3828968-3829186 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT156085 WP_000966688.1 NZ_CP053098:c2224372-2223968 [Acinetobacter baumannii ATCC 17978]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT156085 NZ_CP068826:3828568-3828942 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References