Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 395139..395818 Replicon chromosome
Accession NZ_CP091335
Organism Acinetobacter baumannii strain ATCC17978-VUB

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag L2Z42_RS01945 Protein ID WP_000838146.1
Coordinates 395139..395321 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag L2Z42_RS01950 Protein ID WP_000966688.1
Coordinates 395414..395818 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z42_RS01910 (L2Z42_01910) 390382..390780 + 399 WP_001251846.1 phage tail terminator-like protein -
L2Z42_RS01915 (L2Z42_01915) 390782..391000 + 219 WP_001277696.1 hypothetical protein -
L2Z42_RS01920 (L2Z42_01920) 391109..391630 + 522 WP_000749906.1 SH3 domain-containing protein -
L2Z42_RS01925 (L2Z42_01925) 391727..392080 + 354 WP_000064603.1 hypothetical protein -
L2Z42_RS01930 (L2Z42_01930) 392080..393258 + 1179 WP_000002414.1 hypothetical protein -
L2Z42_RS01935 (L2Z42_01935) 393311..394228 + 918 WP_000094261.1 phage tail tube protein -
L2Z42_RS01940 (L2Z42_01940) 394298..394813 + 516 WP_001185604.1 hypothetical protein -
L2Z42_RS01945 (L2Z42_01945) 395139..395321 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
L2Z42_RS01950 (L2Z42_01950) 395414..395818 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L2Z42_RS01955 (L2Z42_01955) 395918..396094 + 177 WP_074031683.1 hypothetical protein -
L2Z42_RS01960 (L2Z42_01960) 396103..396426 + 324 WP_000523932.1 DUF4236 domain-containing protein -
L2Z42_RS01965 (L2Z42_01965) 396460..396849 + 390 WP_031977960.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 361115..410453 49338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T233190 WP_000838146.1 NZ_CP091335:395139-395321 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T233190 NZ_FO704550:c545334-544945 [Xenorhabdus doucetiae]
ATGTACATGTTGGATACCAATATCGTCAGTTACATTTTTCGGCAACATCCGACAGTCATAGCCAAATTACGCACCGTATC
ACCCTCAGAAATAGGGATATCCTCCATTACTGAGGCCGAGTTGCGTTATGGCCTGGCCAGACGCCAAAACAGTACCCTTG
AGCATATCGTAAACACATTTATTGATTCGATTACAGTTTACGATTGGGATCAAAATGCGGCAAAAGTCTATGGGACGTTA
CGCGCCGGAATGGAAAAAACGGGCAGAACAATGGGAACAATGGATCAGTTGATTGCCGCTCACGCCCTGAGCCGGGGATT
AACTCTTGTTACCAGCGATTCAGCGTTTGGAATGGTGTCTGATTTAACTATCGAGGACTGGACAAAATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT233190 WP_000966688.1 NZ_CP091335:395414-395818 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT233190 NZ_FO704550:c545594-545334 [Xenorhabdus doucetiae]
ATGGAACGAGTCGCAAAAATATTCAAAAATGGCCGTAATCAGGCTGTGAGGCTGCCTGTTGCATTTGAATTCGACACTGA
TCATGTTTATATCCGAAAAAATGAAAACGGGGACGTTATTCTCTCTAAAAACAAATCAACTGATAATTGGGACAGTTTTC
TCAATATGTTACACACATTGTCCGTTCCTGATGATTTTTTAAATATAAATGAACGCAATCAGGAGATTACACAGCGTGAC
CCATTTGGAGACATTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References