Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1623956..1624635 Replicon chromosome
Accession NZ_CP033110
Organism Acinetobacter baumannii ATCC 17978

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag EAV54_RS07710 Protein ID WP_000838146.1
Coordinates 1623956..1624138 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag EAV54_RS07715 Protein ID WP_000966688.1
Coordinates 1624231..1624635 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAV54_RS07675 (EAV54_07695) 1619199..1619597 + 399 WP_001251846.1 phage tail terminator-like protein -
EAV54_RS07680 (EAV54_07700) 1619599..1619817 + 219 WP_001277696.1 hypothetical protein -
EAV54_RS07685 (EAV54_07705) 1619926..1620447 + 522 WP_000749906.1 SH3 domain-containing protein -
EAV54_RS07690 (EAV54_07710) 1620544..1620897 + 354 WP_000064603.1 hypothetical protein -
EAV54_RS07695 (EAV54_07715) 1620897..1622075 + 1179 WP_000002414.1 hypothetical protein -
EAV54_RS07700 (EAV54_07720) 1622128..1623045 + 918 WP_000094261.1 phage tail tube protein -
EAV54_RS07705 (EAV54_07725) 1623115..1623630 + 516 WP_001185604.1 hypothetical protein -
EAV54_RS07710 (EAV54_07735) 1623956..1624138 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
EAV54_RS07715 (EAV54_07740) 1624231..1624635 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EAV54_RS07720 (EAV54_07745) 1624735..1624911 + 177 WP_074031683.1 hypothetical protein -
EAV54_RS07725 (EAV54_07750) 1624920..1625243 + 324 WP_000523932.1 DUF4236 domain-containing protein -
EAV54_RS07730 (EAV54_07755) 1625277..1625666 + 390 WP_031977960.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1588570..1639270 50700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T113186 WP_000838146.1 NZ_CP033110:1623956-1624138 [Acinetobacter baumannii ATCC 17978]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T113186 NZ_CP033110:1623956-1624138 [Acinetobacter baumannii ATCC 17978]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT113186 WP_000966688.1 NZ_CP033110:1624231-1624635 [Acinetobacter baumannii ATCC 17978]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT113186 NZ_CP033110:1624231-1624635 [Acinetobacter baumannii ATCC 17978]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References