Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3720585..3721264 Replicon chromosome
Accession NZ_CP043910
Organism Acinetobacter baumannii strain AB043

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag AT571_RS17835 Protein ID WP_000838146.1
Coordinates 3721082..3721264 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag AT571_RS17830 Protein ID WP_000966688.1
Coordinates 3720585..3720989 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT571_RS17815 3719554..3719943 - 390 WP_031977960.1 hypothetical protein -
AT571_RS17820 3719977..3720300 - 324 WP_000523932.1 DUF4236 domain-containing protein -
AT571_RS17825 3720309..3720485 - 177 WP_074031683.1 hypothetical protein -
AT571_RS17830 3720585..3720989 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AT571_RS17835 3721082..3721264 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
AT571_RS17845 3721590..3722105 - 516 WP_001185604.1 hypothetical protein -
AT571_RS17850 3722175..3723092 - 918 WP_000094261.1 hypothetical protein -
AT571_RS17855 3723145..3724323 - 1179 WP_000002414.1 hypothetical protein -
AT571_RS17860 3724323..3724676 - 354 WP_000064603.1 hypothetical protein -
AT571_RS17865 3724773..3725294 - 522 WP_000749906.1 SH3 domain-containing protein -
AT571_RS17870 3725403..3725621 - 219 WP_001277696.1 hypothetical protein -
AT571_RS17875 3725623..3726021 - 399 WP_001251846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3705950..3755288 49338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T139462 WP_000838146.1 NZ_CP043910:c3721264-3721082 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T139462 NZ_CP058690:c1196366-1196040 [Paracoccus pantotrophus]
ATGACGCGCGGCGATCTGGTGGCGGTTGCGCTGCAAGGGGATCATGGCAAGCCGCGTCCTGCACTGATCATCCAGGCGGA
CCAATTCCCCGGCACTGCCACGGTTACGGTACTGCTGGTTACATCAACGCTGGTCGATGCCCCGTTGTTGCGGCTGACGG
TCGAGCCGTCGCCCGAAAACGGGCTGCGAAAACCGTCCCAGATCATGATCGACAAACCGATGACCGTGCGGATCGACAAG
ATCGGTGCCGCCTTCGGCAGGCTGGACGACGCCGCGCTGGTCAGCGTGAACAGGTCGCTGGCGCTGTTTCTGGGGCTGGC
GGGTTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT139462 WP_000966688.1 NZ_CP043910:c3720989-3720585 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT139462 NZ_CP058690:c1196697-1196479 [Paracoccus pantotrophus]
ATGCCAACCCCCGTTTCGGAACGTGTGCAAAGGCGGCGCGATGCCCTGCGGGCCGCAGGTCTGCGGCCTGTACAGATCTG
GGTGCCAGACACCCGCCGTCCCGGCTTTGCCGATGAGTGCCGCCGTCAGGCCGCTCTGGTCGCGCAGGCGGATCGTCGCG
ATGCCGGTCTGGATGATTTCATGGATGCTGCCCTATTCGATATGGATGACTGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References