Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 3720585..3721264 | Replicon | chromosome |
Accession | NZ_CP043910 | ||
Organism | Acinetobacter baumannii strain AB043 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | S3TWT7 |
Locus tag | AT571_RS17835 | Protein ID | WP_000838146.1 |
Coordinates | 3721082..3721264 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | N9L2H6 |
Locus tag | AT571_RS17830 | Protein ID | WP_000966688.1 |
Coordinates | 3720585..3720989 (-) | Length | 135 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AT571_RS17815 | 3719554..3719943 | - | 390 | WP_031977960.1 | hypothetical protein | - |
AT571_RS17820 | 3719977..3720300 | - | 324 | WP_000523932.1 | DUF4236 domain-containing protein | - |
AT571_RS17825 | 3720309..3720485 | - | 177 | WP_074031683.1 | hypothetical protein | - |
AT571_RS17830 | 3720585..3720989 | - | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
AT571_RS17835 | 3721082..3721264 | - | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
AT571_RS17845 | 3721590..3722105 | - | 516 | WP_001185604.1 | hypothetical protein | - |
AT571_RS17850 | 3722175..3723092 | - | 918 | WP_000094261.1 | hypothetical protein | - |
AT571_RS17855 | 3723145..3724323 | - | 1179 | WP_000002414.1 | hypothetical protein | - |
AT571_RS17860 | 3724323..3724676 | - | 354 | WP_000064603.1 | hypothetical protein | - |
AT571_RS17865 | 3724773..3725294 | - | 522 | WP_000749906.1 | SH3 domain-containing protein | - |
AT571_RS17870 | 3725403..3725621 | - | 219 | WP_001277696.1 | hypothetical protein | - |
AT571_RS17875 | 3725623..3726021 | - | 399 | WP_001251846.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 3705950..3755288 | 49338 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T139462 WP_000838146.1 NZ_CP043910:c3721264-3721082 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T139462 NZ_CP058690:c1196366-1196040 [Paracoccus pantotrophus]
ATGACGCGCGGCGATCTGGTGGCGGTTGCGCTGCAAGGGGATCATGGCAAGCCGCGTCCTGCACTGATCATCCAGGCGGA
CCAATTCCCCGGCACTGCCACGGTTACGGTACTGCTGGTTACATCAACGCTGGTCGATGCCCCGTTGTTGCGGCTGACGG
TCGAGCCGTCGCCCGAAAACGGGCTGCGAAAACCGTCCCAGATCATGATCGACAAACCGATGACCGTGCGGATCGACAAG
ATCGGTGCCGCCTTCGGCAGGCTGGACGACGCCGCGCTGGTCAGCGTGAACAGGTCGCTGGCGCTGTTTCTGGGGCTGGC
GGGTTAG
ATGACGCGCGGCGATCTGGTGGCGGTTGCGCTGCAAGGGGATCATGGCAAGCCGCGTCCTGCACTGATCATCCAGGCGGA
CCAATTCCCCGGCACTGCCACGGTTACGGTACTGCTGGTTACATCAACGCTGGTCGATGCCCCGTTGTTGCGGCTGACGG
TCGAGCCGTCGCCCGAAAACGGGCTGCGAAAACCGTCCCAGATCATGATCGACAAACCGATGACCGTGCGGATCGACAAG
ATCGGTGCCGCCTTCGGCAGGCTGGACGACGCCGCGCTGGTCAGCGTGAACAGGTCGCTGGCGCTGTTTCTGGGGCTGGC
GGGTTAG
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT139462 WP_000966688.1 NZ_CP043910:c3720989-3720585 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT139462 NZ_CP058690:c1196697-1196479 [Paracoccus pantotrophus]
ATGCCAACCCCCGTTTCGGAACGTGTGCAAAGGCGGCGCGATGCCCTGCGGGCCGCAGGTCTGCGGCCTGTACAGATCTG
GGTGCCAGACACCCGCCGTCCCGGCTTTGCCGATGAGTGCCGCCGTCAGGCCGCTCTGGTCGCGCAGGCGGATCGTCGCG
ATGCCGGTCTGGATGATTTCATGGATGCTGCCCTATTCGATATGGATGACTGGGAATGA
ATGCCAACCCCCGTTTCGGAACGTGTGCAAAGGCGGCGCGATGCCCTGCGGGCCGCAGGTCTGCGGCCTGTACAGATCTG
GGTGCCAGACACCCGCCGTCCCGGCTTTGCCGATGAGTGCCGCCGTCAGGCCGCTCTGGTCGCGCAGGCGGATCGTCGCG
ATGCCGGTCTGGATGATTTCATGGATGCTGCCCTATTCGATATGGATGACTGGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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