55407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1625432..1626111 Replicon chromosome
Accession NZ_CP012004
Organism Acinetobacter baumannii strain ATCC 17978-mff

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag ACX60_RS07635 Protein ID WP_000838146.1
Coordinates 1625432..1625614 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag ACX60_RS07640 Protein ID WP_000966688.1
Coordinates 1625707..1626111 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACX60_RS07600 1620675..1621073 + 399 WP_001251846.1 hypothetical protein -
ACX60_RS07605 1621075..1621293 + 219 WP_001277696.1 hypothetical protein -
ACX60_RS07610 1621402..1621923 + 522 WP_000749906.1 SH3 domain-containing protein -
ACX60_RS07615 1622020..1622373 + 354 WP_000064603.1 hypothetical protein -
ACX60_RS07620 1622373..1623551 + 1179 WP_000002414.1 hypothetical protein -
ACX60_RS07625 1623604..1624521 + 918 WP_000094261.1 hypothetical protein -
ACX60_RS07630 1624591..1625106 + 516 WP_001185604.1 hypothetical protein -
ACX60_RS07635 1625432..1625614 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
ACX60_RS07640 1625707..1626111 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ACX60_RS19115 1626211..1626387 + 177 WP_074031683.1 hypothetical protein -
ACX60_RS07645 1626396..1626719 + 324 WP_000523932.1 DUF4236 domain-containing protein -
ACX60_RS07650 1626753..1627142 + 390 WP_031977960.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1591408..1640746 49338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T55407 WP_000838146.1 NZ_CP012004:1625432-1625614 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T55407 NZ_CP012004:1625432-1625614 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT55407 WP_000966688.1 NZ_CP012004:1625707-1626111 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT55407 NZ_CP012004:1625707-1626111 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References