Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2225272..2225951 Replicon chromosome
Accession NZ_CP059041
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag H0N28_RS10605 Protein ID WP_000838146.1
Coordinates 2225769..2225951 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag H0N28_RS10600 Protein ID WP_000966688.1
Coordinates 2225272..2225676 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0N28_RS10585 2224241..2224630 - 390 WP_031977960.1 hypothetical protein -
H0N28_RS10590 2224664..2224987 - 324 WP_000523932.1 DUF4236 domain-containing protein -
H0N28_RS10595 2224996..2225172 - 177 WP_074031683.1 hypothetical protein -
H0N28_RS10600 2225272..2225676 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H0N28_RS10605 2225769..2225951 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
H0N28_RS10610 2226277..2226792 - 516 WP_001185604.1 hypothetical protein -
H0N28_RS10615 2226862..2227779 - 918 WP_000094261.1 hypothetical protein -
H0N28_RS10620 2227832..2229010 - 1179 WP_000002414.1 hypothetical protein -
H0N28_RS10625 2229010..2229363 - 354 WP_000064603.1 hypothetical protein -
H0N28_RS10630 2229460..2229981 - 522 WP_000749906.1 SH3 domain-containing protein -
H0N28_RS10635 2230090..2230308 - 219 WP_001277696.1 hypothetical protein -
H0N28_RS10640 2230310..2230708 - 399 WP_001251846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2210637..2261336 50699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T168105 WP_000838146.1 NZ_CP059041:c2225951-2225769 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T168105 NZ_CP075632:4914603-4915001 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT168105 WP_000966688.1 NZ_CP059041:c2225676-2225272 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT168105 NZ_CP075632:4914376-4914603 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References