Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2225272..2225951 Replicon chromosome
Accession NZ_CP059041
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag H0N28_RS10605 Protein ID WP_000838146.1
Coordinates 2225769..2225951 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag H0N28_RS10600 Protein ID WP_000966688.1
Coordinates 2225272..2225676 (-) Length 135 a.a.

Genomic Context

H0N28_RS10585H0N28_RS10590H0N28_RS10595H0N28_RS10600H0N28_RS10605H0N28_RS10610H0N28_RS10615H0N28_RS10620H0N28_RS10625H0N28_RS10630H0N28_RS10635H0N28_RS10640
Location: 2224241..2224630 (390 bp)
Type: Others
Protein ID: WP_031977960.1
Location: 2224664..2224987 (324 bp)
Type: Others
Protein ID: WP_000523932.1
Location: 2224996..2225172 (177 bp)
Type: Others
Protein ID: WP_074031683.1
Location: 2225272..2225676 (405 bp)
Type: Antitoxin
Protein ID: WP_000966688.1
Location: 2225769..2225951 (183 bp)
Type: Toxin
Protein ID: WP_000838146.1
Location: 2226277..2226792 (516 bp)
Type: Others
Protein ID: WP_001185604.1
Location: 2226862..2227779 (918 bp)
Type: Others
Protein ID: WP_000094261.1
Location: 2227832..2229010 (1179 bp)
Type: Others
Protein ID: WP_000002414.1
Location: 2229010..2229363 (354 bp)
Type: Others
Protein ID: WP_000064603.1
Location: 2229460..2229981 (522 bp)
Type: Others
Protein ID: WP_000749906.1
Location: 2230090..2230308 (219 bp)
Type: Others
Protein ID: WP_001277696.1
Location: 2230310..2230708 (399 bp)
Type: Others
Protein ID: WP_001251846.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H0N28_RS105852224241..2224630-390WP_031977960.1hypothetical protein-
H0N28_RS105902224664..2224987-324WP_000523932.1DUF4236 domain-containing protein-
H0N28_RS105952224996..2225172-177WP_074031683.1hypothetical protein-
H0N28_RS106002225272..2225676-405WP_000966688.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
H0N28_RS106052225769..2225951-183WP_000838146.1type II toxin-antitoxin system HicA family toxinToxin
H0N28_RS106102226277..2226792-516WP_001185604.1hypothetical protein-
H0N28_RS106152226862..2227779-918WP_000094261.1hypothetical protein-
H0N28_RS106202227832..2229010-1179WP_000002414.1hypothetical protein-
H0N28_RS106252229010..2229363-354WP_000064603.1hypothetical protein-
H0N28_RS106302229460..2229981-522WP_000749906.1SH3 domain-containing protein-
H0N28_RS106352230090..2230308-219WP_001277696.1hypothetical protein-
H0N28_RS106402230310..2230708-399WP_001251846.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--2210637..226133650699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T168105 WP_000838146.1 NZ_CP059041:c2225951-2225769 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T168105 NZ_CP075632:4914603-4915001 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT168105 WP_000966688.1 NZ_CP059041:c2225676-2225272 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT168105 NZ_CP075632:4914376-4914603 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS3TWT7

Antitoxin

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Source
ID
Structure
AlphaFold DBN9L2H6

References