Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1888291..1888970 Replicon chromosome
Accession NZ_CP074710
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag KIP77_RS10025 Protein ID WP_000838146.1
Coordinates 1888291..1888473 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag KIP77_RS10030 Protein ID WP_000966688.1
Coordinates 1888566..1888970 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIP77_RS09990 (KIP77_09955) 1883534..1883932 + 399 WP_001251846.1 phage tail terminator-like protein -
KIP77_RS09995 (KIP77_09960) 1883934..1884152 + 219 WP_001277696.1 hypothetical protein -
KIP77_RS10000 (KIP77_09965) 1884261..1884782 + 522 WP_000749906.1 SH3 domain-containing protein -
KIP77_RS10005 (KIP77_09970) 1884879..1885232 + 354 WP_000064603.1 hypothetical protein -
KIP77_RS10010 (KIP77_09975) 1885232..1886410 + 1179 WP_000002414.1 hypothetical protein -
KIP77_RS10015 (KIP77_09980) 1886463..1887380 + 918 WP_000094261.1 phage tail tube protein -
KIP77_RS10020 (KIP77_09985) 1887450..1887965 + 516 WP_001185604.1 hypothetical protein -
KIP77_RS10025 (KIP77_09990) 1888291..1888473 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
KIP77_RS10030 (KIP77_09995) 1888566..1888970 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KIP77_RS10035 (KIP77_10000) 1889070..1889246 + 177 WP_074031683.1 hypothetical protein -
KIP77_RS10040 (KIP77_10005) 1889255..1889578 + 324 WP_000523932.1 DUF4236 domain-containing protein -
KIP77_RS10045 (KIP77_10010) 1889612..1890001 + 390 WP_031977960.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1854267..1903605 49338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T202698 WP_000838146.1 NZ_CP074710:1888291-1888473 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T202698 NZ_CP099590:183644-183751 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT202698 WP_000966688.1 NZ_CP074710:1888566-1888970 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT202698 NZ_CP099590:c183595-183532 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References