Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3763590..3764269 Replicon chromosome
Accession NZ_CP019034
Organism Acinetobacter baumannii strain AB042

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag AT570_RS18050 Protein ID WP_000838146.1
Coordinates 3764087..3764269 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag AT570_RS18045 Protein ID WP_000966688.1
Coordinates 3763590..3763994 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT570_RS18030 3762559..3762948 - 390 WP_031977960.1 hypothetical protein -
AT570_RS18035 3762982..3763305 - 324 WP_000523932.1 DUF4236 domain-containing protein -
AT570_RS18040 3763314..3763490 - 177 WP_074031683.1 hypothetical protein -
AT570_RS18045 3763590..3763994 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AT570_RS18050 3764087..3764269 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
AT570_RS18060 3764595..3765110 - 516 WP_001185604.1 hypothetical protein -
AT570_RS18065 3765180..3766097 - 918 WP_000094261.1 hypothetical protein -
AT570_RS18070 3766150..3767328 - 1179 WP_000002414.1 hypothetical protein -
AT570_RS18075 3767328..3767681 - 354 WP_000064603.1 hypothetical protein -
AT570_RS18080 3767778..3768299 - 522 WP_000749906.1 SH3 domain-containing protein -
AT570_RS18085 3768408..3768626 - 219 WP_001277696.1 hypothetical protein -
AT570_RS18090 3768628..3769026 - 399 WP_001251846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3748955..3798293 49338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T71576 WP_000838146.1 NZ_CP019034:c3764269-3764087 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T71576 NZ_CP019034:c3764269-3764087 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT71576 WP_000966688.1 NZ_CP019034:c3763994-3763590 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT71576 NZ_CP019034:c3763994-3763590 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References