Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   Q7621_RS11010 Genome accession   NZ_CP131712
Coordinates   2204137..2204262 (-) Length   41 a.a.
NCBI ID   WP_000799694.1    Uniprot ID   Q9WW44
Organism   Streptococcus pneumoniae strain 2008C09-280     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2199137..2209262
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7621_RS10980 (Q7621_10965) - 2199476..2201078 (-) 1603 Protein_2125 YhgE/Pip domain-containing protein -
  Q7621_RS10985 (Q7621_10970) - 2201257..2201799 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  Q7621_RS11000 (Q7621_10985) comE 2202042..2202794 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  Q7621_RS11005 (Q7621_10990) comD/comD2 2202791..2204116 (-) 1326 WP_341966604.1 competence system sensor histidine kinase ComD Regulator
  Q7621_RS11010 (Q7621_10995) comC/comC2 2204137..2204262 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  Q7621_RS11020 (Q7621_11005) rlmH 2204544..2205023 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  Q7621_RS11025 (Q7621_11010) htrA 2205206..2206387 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  Q7621_RS11030 (Q7621_11015) spo0J 2206445..2207203 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4892.93 Da        Isoelectric Point: 10.9061

>NTDB_id=864315 Q7621_RS11010 WP_000799694.1 2204137..2204262(-) (comC/comC2) [Streptococcus pneumoniae strain 2008C09-280]
MKNTVKLEQFVALKEKDLQNIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=864315 Q7621_RS11010 WP_000799694.1 2204137..2204262(-) (comC/comC2) [Streptococcus pneumoniae strain 2008C09-280]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAATATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9WW44

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

97.561

100

0.976
  comC/comC2 Streptococcus pneumoniae TIGR4

97.561

100

0.976
  comC/comC1 Streptococcus pneumoniae R6

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae G54

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae D39

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae Rx1

78.049

100

0.78
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

60

97.561

0.585