Detailed information    

insolico Bioinformatically predicted

Overview


Name   comR/comR2   Type   Regulator
Locus tag   SITYG_RS00080 Genome accession   NZ_AP014880
Coordinates   18940..19413 (+) Length   157 a.a.
NCBI ID   WP_096362333.1    Uniprot ID   -
Organism   Streptococcus intermedius strain TYG1620     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 203..47563 18940..19413 within 0


Gene organization within MGE regions


Location: 203..47563
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SITYG_RS00005 (SITYG_00010) dnaA 203..1546 (+) 1344 WP_096362325.1 chromosomal replication initiator protein DnaA -
  SITYG_RS00010 (SITYG_00020) dnaN 1702..2838 (+) 1137 WP_003075500.1 DNA polymerase III subunit beta -
  SITYG_RS00015 (SITYG_00030) - 2838..3035 (+) 198 WP_003075608.1 DUF951 domain-containing protein -
  SITYG_RS00020 (SITYG_00040) - 3058..3558 (-) 501 WP_003075599.1 DUF1307 domain-containing protein -
  SITYG_RS00025 (SITYG_00050) ychF 3704..4819 (+) 1116 WP_096362326.1 redox-regulated ATPase YchF -
  SITYG_RS00030 (SITYG_00060) pth 4891..5460 (+) 570 WP_021002259.1 aminoacyl-tRNA hydrolase -
  SITYG_RS00035 (SITYG_00070) mfd 5453..8959 (+) 3507 WP_096362327.1 transcription-repair coupling factor -
  SITYG_RS00040 (SITYG_00080) - 9039..9305 (+) 267 WP_096362328.1 RNA-binding S4 domain-containing protein -
  SITYG_RS00045 (SITYG_00090) - 9298..9666 (+) 369 WP_003075514.1 septum formation initiator family protein -
  SITYG_RS10725 (SITYG_00100) - 9669..9797 (+) 129 WP_096362329.1 SP_0009 family protein -
  SITYG_RS00055 (SITYG_00110) - 9790..11070 (+) 1281 WP_096362330.1 serine hydrolase -
  SITYG_RS00060 (SITYG_00120) tilS 11067..12344 (+) 1278 WP_009569755.1 tRNA lysidine(34) synthetase TilS -
  SITYG_RS00065 (SITYG_00130) hpt 12350..12892 (+) 543 WP_096362331.1 hypoxanthine phosphoribosyltransferase -
  SITYG_RS00070 (SITYG_00140) ftsH 12913..14883 (+) 1971 WP_003075525.1 ATP-dependent zinc metalloprotease FtsH -
  SITYG_RS00075 (SITYG_00150) - 15857..18619 (+) 2763 WP_096362332.1 sialidase domain-containing protein -
  SITYG_RS00080 (SITYG_00160) comR/comR2 18940..19413 (+) 474 WP_096362333.1 transcriptional regulator Regulator
  SITYG_RS00190 (SITYG_00170) mreC 26375..27181 (+) 807 WP_096362334.1 rod shape-determining protein MreC -
  SITYG_RS00195 (SITYG_00180) mreD 27183..27683 (+) 501 WP_003075140.1 rod shape-determining protein MreD -
  SITYG_RS00200 (SITYG_00190) pcsB 27793..28974 (+) 1182 WP_003077627.1 peptidoglycan hydrolase PcsB -
  SITYG_RS00205 (SITYG_00200) - 29108..30076 (+) 969 WP_048785444.1 ribose-phosphate diphosphokinase -
  SITYG_RS00210 (SITYG_00210) - 30240..31427 (+) 1188 WP_009567704.1 pyridoxal phosphate-dependent aminotransferase -
  SITYG_RS00215 (SITYG_00220) recO 31405..32178 (+) 774 WP_096362335.1 DNA repair protein RecO -
  SITYG_RS00220 (SITYG_00230) plsX 32175..33173 (+) 999 WP_096362336.1 phosphate acyltransferase PlsX -
  SITYG_RS00225 (SITYG_00240) - 33170..33415 (+) 246 WP_003075134.1 acyl carrier protein -
  SITYG_RS00230 (SITYG_00250) purC 33560..34267 (+) 708 WP_096362337.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SITYG_RS00235 (SITYG_00260) - 34277..38002 (+) 3726 WP_096362338.1 phosphoribosylformylglycinamidine synthase -
  SITYG_RS00240 (SITYG_00270) - 38024..38644 (+) 621 WP_096362339.1 DNA alkylation repair protein -
  SITYG_RS00245 (SITYG_00280) purF 38670..40109 (+) 1440 WP_096362340.1 amidophosphoribosyltransferase -
  SITYG_RS00250 (SITYG_00290) purM 40356..41378 (+) 1023 WP_096363309.1 phosphoribosylformylglycinamidine cyclo-ligase -
  SITYG_RS00255 (SITYG_00300) purN 41378..41935 (+) 558 WP_096362341.1 phosphoribosylglycinamide formyltransferase -
  SITYG_RS00260 (SITYG_00310) - 41968..42867 (+) 900 WP_096362342.1 exonuclease domain-containing protein -
  SITYG_RS00270 (SITYG_00320) purH 43203..44753 (+) 1551 WP_096362343.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  SITYG_RS00275 (SITYG_00330) - 44805..46727 (-) 1923 WP_096362344.1 GBS Bsp-like repeat-containing protein -

Sequence


Protein


Download         Length: 157 a.a.        Molecular weight: 19402.35 Da        Isoelectric Point: 8.9104

>NTDB_id=67231 SITYG_RS00080 WP_096362333.1 18940..19413(+) (comR/comR2) [Streptococcus intermedius strain TYG1620]
MDFKELYEKVRGIVLKSRREYYVHLWELSDWDQEGMMVLYELVSRHPYLVEEEAHLYVYYKTKFRNHIKDILRKQESQKR
KLDRQVYEEVSEIGHKLSLKGLYLDELVILRDQLKSYQKQLSPAKQEQYERLLADERFKGRQAMLRELRTYLKDYEM

Nucleotide


Download         Length: 474 bp        

>NTDB_id=67231 SITYG_RS00080 WP_096362333.1 18940..19413(+) (comR/comR2) [Streptococcus intermedius strain TYG1620]
ATGGATTTCAAGGAGTTATATGAGAAAGTAAGGGGAATTGTGCTGAAGAGTCGACGGGAATATTATGTCCATCTGTGGGA
GCTAAGCGATTGGGACCAAGAAGGGATGATGGTCTTGTATGAGTTGGTAAGTCGCCACCCCTATTTGGTAGAGGAAGAAG
CCCATCTCTATGTCTACTATAAGACAAAGTTTCGGAATCACATAAAGGATATTCTGCGCAAACAAGAAAGTCAAAAGCGC
AAACTGGATCGCCAAGTGTATGAAGAGGTAAGTGAGATTGGGCACAAGTTAAGTCTGAAAGGTCTGTATCTAGACGAGTT
GGTAATACTCCGCGATCAATTAAAGTCCTATCAAAAGCAACTGAGTCCCGCCAAGCAAGAGCAGTATGAGCGGTTACTGG
CAGATGAAAGGTTCAAAGGCCGCCAAGCGATGCTTCGAGAGTTACGAACCTACTTAAAAGACTATGAGATGTAG

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

60

98.726

0.592

  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

60

98.726

0.592

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

56.129

98.726

0.554

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

55.484

98.726

0.548

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

54.839

98.726

0.541

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

54.839

98.726

0.541

  comX/comX1 Streptococcus pneumoniae Rx1

54.194

98.726

0.535

  comX/comX2 Streptococcus pneumoniae D39

54.194

98.726

0.535

  comX/comX1 Streptococcus pneumoniae D39

54.194

98.726

0.535

  comX/comX2 Streptococcus pneumoniae R6

54.194

98.726

0.535

  comX/comX1 Streptococcus pneumoniae R6

54.194

98.726

0.535

  comX/comX2 Streptococcus pneumoniae Rx1

54.194

98.726

0.535

  comX/comX1 Streptococcus pneumoniae TIGR4

53.548

98.726

0.529

  comX/comX2 Streptococcus pneumoniae TIGR4

53.548

98.726

0.529

  comX/sigX Streptococcus mutans UA159

50.649

98.089

0.497

  comX/sigX Streptococcus suis D9

49.032

98.726

0.484

  comX/sigX Streptococcus suis isolate S10

49.032

98.726

0.484

  comX/sigX Streptococcus suis P1/7

49.032

98.726

0.484

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

43.226

98.726

0.427

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

43.226

98.726

0.427

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

43.226

98.726

0.427

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

43.226

98.726

0.427

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

43.226

98.726

0.427

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

43.226

98.726

0.427

  comX Streptococcus salivarius SK126

42.857

98.089

0.42

  comX/sigX Streptococcus salivarius strain HSISS4

42.208

98.089

0.414

  comX Streptococcus thermophilus LMG 18311

42.208

98.089

0.414

  comX Streptococcus thermophilus LMD-9

42.208

98.089

0.414

  comX/sigX Streptococcus infantarius subsp. infantarius ATCC BAA-102

39.744

99.363

0.395


Multiple sequence alignment