Detailed information NTG0490190

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ILP78_RS05125
• Genome accession: NZ_CP062465
• Coordinates: 1029546..1030589 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MRSA - AMRF 6
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1024546..1035589

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ILP78_RS05095 (ILP78_05095)	-	1025031..1025141 (+)	111	WP_001790257.1	hypothetical protein	-
ILP78_RS05100 (ILP78_05100)	-	1025170..1025583 (+)	414	WP_025175030.1	hypothetical protein	-
ILP78_RS05105 (ILP78_05105)	-	1026014..1027000 (-)	987	WP_000999713.1	FUSC family protein	-
ILP78_RS05110 (ILP78_05110)	map	1027472..1028230 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ILP78_RS05115 (ILP78_05115)	-	1028447..1028833 (+)	387	WP_001110179.1	hypothetical protein	-
ILP78_RS05120 (ILP78_05120)	liaF	1028848..1029549 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ILP78_RS05125 (ILP78_05125)	vraS	1029546..1030589 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ILP78_RS05130 (ILP78_05130)	vraR	1030579..1031208 (+)	630	WP_000153532.1	two-component system response regulator VraR	Regulator
ILP78_RS05135 (ILP78_05135)	-	1031320..1032537 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
ILP78_RS05140 (ILP78_05140)	-	1032815..1033090 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ILP78_RS05145 (ILP78_05145)	-	1033097..1033561 (-)	465	WP_000567539.1	low molecular weight protein-tyrosine-phosphatase	-
ILP78_RS05150 (ILP78_05150)	-	1033708..1033908 (+)	201	WP_000180460.1	DUF1128 family protein	-
ILP78_RS05155 (ILP78_05155)	-	1033911..1035167 (+)	1257	WP_072398252.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=490190 ILP78_RS05125 WP_001017131.1 1029546..1030589(+) (vraS) [Staphylococcus aureus strain MRSA - AMRF 6]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=490190 ILP78_RS05125 WP_001017131.1 1029546..1030589(+) (vraS) [Staphylococcus aureus strain MRSA - AMRF 6]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTGAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1