Detailed information NTG0337665

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: EQH31_RS04625
• Genome accession: NZ_CP035249
• Coordinates: 906224..906874 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387352.1
• Uniprot ID: A0A4J1SCX2
• Organism: Streptococcus pneumoniae strain TVO_1901938
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 901224..911874

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH31_RS04595 (EQH31_04890)	-	901720..901935 (+)	216	WP_001232078.1	YozE family protein	-
EQH31_RS04600 (EQH31_04895)	-	902021..902989 (+)	969	WP_000658181.1	PhoH family protein	-
EQH31_RS04605 (EQH31_04900)	-	903169..903669 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
EQH31_RS04610 (EQH31_04905)	-	903672..903998 (+)	327	Protein_927	TfoX/Sxy family protein	-
EQH31_RS04615 (EQH31_04910)	ald	904299..905410 (-)	1112	Protein_928	alanine dehydrogenase	-
EQH31_RS04620 (EQH31_04915)	-	905587..906156 (+)	570	WP_000443745.1	GNAT family N-acetyltransferase	-
EQH31_RS04625 (EQH31_04920)	comEA/celA/cilE	906224..906874 (+)	651	WP_000387352.1	helix-hairpin-helix domain-containing protein	Machinery gene
EQH31_RS04630 (EQH31_04925)	comEC/celB	906858..909098 (+)	2241	WP_000942422.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
EQH31_RS04635 (EQH31_04930)	-	909278..909466 (+)	189	WP_010976492.1	hypothetical protein	-
EQH31_RS04640 (EQH31_04935)	-	909498..910085 (+)	588	WP_000933542.1	ATP-binding cassette domain-containing protein	-
EQH31_RS04645 (EQH31_04940)	-	910089..911264 (+)	1176	WP_000655940.1	hypothetical protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23085.30 Da
• Isoelectric Point: 6.0661

>NTDB_id=337665 EQH31_RS04625 WP_000387352.1 906224..906874(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain TVO_1901938]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTSVKETNLQAEVAAVSKDSSTGKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=337665 EQH31_RS04625 WP_000387352.1 906224..906874(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain TVO_1901938]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACATCTGTCAAAGAGACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGACT
CATCGACCGGAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACCATAGAAAAACTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (151-214)

• SLBB domain (SLBB) (76-126)

3D structure

• AlphaFold DB: A0A4J1SCX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus pneumoniae Rx1	95.833	100	0.958
comEA/celA/cilE	Streptococcus pneumoniae D39	95.833	100	0.958
comEA/celA/cilE	Streptococcus pneumoniae R6	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.37	100	0.954
comEA/celA/cilE	Streptococcus mitis SK321	92.593	100	0.926
comEA	Lactococcus lactis subsp. cremoris KW2	44.053	100	0.463
comEA	Latilactobacillus sakei subsp. sakei 23K	34.335	100	0.37