Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CXX08_RS07435 Genome accession   NZ_CP025869
Coordinates   1531733..1532392 (-) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain 503829     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1526733..1537392
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CXX08_RS07410 parE 1526824..1528716 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  CXX08_RS07415 ygiN 1528764..1529078 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  CXX08_RS07420 mdaB 1529109..1529690 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  CXX08_RS07425 ygiZ 1530009..1530341 (+) 333 WP_000912120.1 DUF2645 family protein -
  CXX08_RS07430 qseC 1530387..1531736 (-) 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
  CXX08_RS07435 ciaR 1531733..1532392 (-) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  CXX08_RS07440 ygiW 1532544..1532936 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CXX08_RS07445 ygiV 1532989..1533471 (+) 483 WP_000183494.1 GyrI-like domain-containing protein -
  CXX08_RS07450 parC 1534017..1536275 (+) 2259 WP_001281894.1 DNA topoisomerase IV subunit A -
  CXX08_RS07455 plsC 1536509..1537246 (+) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=220671 CXX08_RS07435 WP_001221502.1 1531733..1532392(-) (ciaR) [Escherichia coli strain 503829]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=220671 CXX08_RS07435 WP_001221502.1 1531733..1532392(-) (ciaR) [Escherichia coli strain 503829]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365

Multiple sequence alignment