Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   SD89_RS00330 Genome accession   NZ_CP010449
Coordinates   53112..54023 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS322     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 48112..59023
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SD89_RS00310 (SD89_00310) purE 48697..49188 (+) 492 WP_041174354.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  SD89_RS00315 (SD89_00315) purK 49175..50248 (+) 1074 WP_053308138.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  SD89_RS00320 (SD89_00320) - 50250..51668 (+) 1419 WP_011888524.1 hypothetical protein -
  SD89_RS00325 (SD89_00325) purB 51689..52981 (+) 1293 WP_014407197.1 adenylosuccinate lyase -
  SD89_RS00330 (SD89_00330) comR 53112..54023 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  SD89_RS10650 comS 54107..54202 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  SD89_RS00335 (SD89_00335) ruvB 54249..55247 (+) 999 WP_053308139.1 Holliday junction branch migration DNA helicase RuvB -
  SD89_RS00340 (SD89_00340) - 55385..55822 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  SD89_RS00345 (SD89_00345) - 55845..56246 (+) 402 WP_012560369.1 MORN repeat-containing protein -
  SD89_RS00350 (SD89_00350) - 56243..58018 (+) 1776 WP_053308140.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=137307 SD89_RS00330 WP_002986681.1 53112..54023(+) (comR) [Streptococcus pyogenes strain NGAS322]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=137307 SD89_RS00330 WP_002986681.1 53112..54023(+) (comR) [Streptococcus pyogenes strain NGAS322]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATTATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment