Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 1873473..1874062 | Replicon | chromosome |
Accession | NC_013971 | ||
Organism | Erwinia amylovora ATCC 49946 |
Toxin (Protein)
Gene name | doc | Uniprot ID | D4I2L7 |
Locus tag | EAM_RS08440 | Protein ID | WP_004157545.1 |
Coordinates | 1873691..1874062 (+) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | D4I2L6 |
Locus tag | EAM_RS08435 | Protein ID | WP_004157544.1 |
Coordinates | 1873473..1873694 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EAM_RS18300 (EAM_1733) | 1869450..1869659 | + | 210 | WP_004157539.1 | glycine zipper 2TM domain-containing protein | - |
EAM_RS08420 (EAM_1734) | 1869772..1870248 | + | 477 | WP_004157540.1 | GNAT family N-acetyltransferase | - |
EAM_RS08425 (EAM_1735) | 1870372..1871121 | + | 750 | WP_004157541.1 | 5'-nucleotidase, lipoprotein e(P4) family | - |
EAM_RS08430 (EAM_1736) | 1871208..1872680 | - | 1473 | WP_004157542.1 | catalase | - |
EAM_RS08435 (EAM_1737) | 1873473..1873694 | + | 222 | WP_004157544.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
EAM_RS08440 (EAM_1738) | 1873691..1874062 | + | 372 | WP_004157545.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
EAM_RS08445 (EAM_1741) | 1874946..1876886 | + | 1941 | WP_004157559.1 | methyl-accepting chemotaxis protein | - |
EAM_RS08450 (EAM_1742) | 1877012..1877647 | + | 636 | WP_004157562.1 | carbonic anhydrase | - |
EAM_RS08455 (EAM_1743) | 1877732..1878181 | - | 450 | WP_004157563.1 | DUF4385 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1858737..1876886 | 18149 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13667.70 Da Isoelectric Point: 7.4182
>T24688 WP_004157545.1 NC_013971:1873691-1874062 [Erwinia amylovora ATCC 49946]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST
Download Length: 372 bp
>T24688 NC_013971:1873691-1874062 [Erwinia amylovora ATCC 49946]
ATGATTTATTTTCTATCCAGTCAAGACATCATCGGCATTCATCAGCGTATGATCGTCGCTTACGGCGGTCTTGCCGGTTA
TGCCGATCCTGGTCGGATAGAAAGTATGGCAACACGGATTCTGAACCGCCACATCTACGAAGGTGAGGATGATATCTATA
TTCTGGCAGCTGCATATCTGCTGGCCATTGCGCGCGGGCATTGTTTCAATGATGCAAATAAGAGAACCGCATTTGCTTCA
ACTGCTTTATTCCTGCGCCGTAATGGCATTCTTCTTCGCTTTTCCCCAATCCATGAACAGCTGACTGTCTCAGCAGCACA
GGGGAGCCTGGATGTGTGGCACATTGCTGAAGCACTGAAACAGTCGACATAA
ATGATTTATTTTCTATCCAGTCAAGACATCATCGGCATTCATCAGCGTATGATCGTCGCTTACGGCGGTCTTGCCGGTTA
TGCCGATCCTGGTCGGATAGAAAGTATGGCAACACGGATTCTGAACCGCCACATCTACGAAGGTGAGGATGATATCTATA
TTCTGGCAGCTGCATATCTGCTGGCCATTGCGCGCGGGCATTGTTTCAATGATGCAAATAAGAGAACCGCATTTGCTTCA
ACTGCTTTATTCCTGCGCCGTAATGGCATTCTTCTTCGCTTTTCCCCAATCCATGAACAGCTGACTGTCTCAGCAGCACA
GGGGAGCCTGGATGTGTGGCACATTGCTGAAGCACTGAAACAGTCGACATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8173.24 Da Isoelectric Point: 4.9861
>AT24688 WP_004157544.1 NC_013971:1873473-1873694 [Erwinia amylovora ATCC 49946]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR
Download Length: 222 bp
>AT24688 NC_013971:1873473-1873694 [Erwinia amylovora ATCC 49946]
ATGCAAGCTATAAACTTTACTACCGCCCGTAACGAACTGGCATCAGTTCTTGATAGCGTTGCCAGCGGTGAGCCAGTTAT
GATCACCCGCAGATCGGCCAAATCCGTGGTTGTGGTTGATGCCGCGCAGTATGAAAAAATGCAAAAAATTCAGGCAGAAT
CGGACTTTGATTGGTTGTTTACAGAACATGGCCAGACGCTTGAAGCTCTTAAAAACCGATGA
ATGCAAGCTATAAACTTTACTACCGCCCGTAACGAACTGGCATCAGTTCTTGATAGCGTTGCCAGCGGTGAGCCAGTTAT
GATCACCCGCAGATCGGCCAAATCCGTGGTTGTGGTTGATGCCGCGCAGTATGAAAAAATGCAAAAAATTCAGGCAGAAT
CGGACTTTGATTGGTTGTTTACAGAACATGGCCAGACGCTTGAAGCTCTTAAAAACCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | D4I2L7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831A2K1 |