Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1929495..1930084 Replicon chromosome
Accession NZ_CP104022
Organism Erwinia amylovora strain Ea102

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag MTP49_RS08525 Protein ID WP_004157545.1
Coordinates 1929495..1929866 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag MTP49_RS08530 Protein ID WP_004157544.1
Coordinates 1929863..1930084 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP49_RS08510 (MTP49_08510) 1925376..1925825 + 450 WP_004157563.1 DUF4385 domain-containing protein -
MTP49_RS08515 (MTP49_08515) 1925910..1926545 - 636 WP_004157562.1 carbonic anhydrase -
MTP49_RS08520 (MTP49_08520) 1926671..1928611 - 1941 WP_004157559.1 methyl-accepting chemotaxis protein -
MTP49_RS08525 (MTP49_08525) 1929495..1929866 - 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MTP49_RS08530 (MTP49_08530) 1929863..1930084 - 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTP49_RS08535 (MTP49_08535) 1930877..1932349 + 1473 WP_004157542.1 catalase -
MTP49_RS08540 (MTP49_08540) 1932436..1933185 - 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
MTP49_RS08545 (MTP49_08545) 1933309..1933785 - 477 WP_004157540.1 GNAT family N-acetyltransferase -
MTP49_RS08550 (MTP49_08550) 1933898..1934107 - 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1929495..1945756 16261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T257028 WP_004157545.1 NZ_CP104022:c1929866-1929495 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT257028 WP_004157544.1 NZ_CP104022:c1930084-1929863 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References