294489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/-
Location 2039450..2040039 Replicon chromosome
Accession NZ_NQJO01000001
Organism Erwinia amylovora strain CTBT3-1 tig00000000

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag CS942_RS09540 Protein ID WP_004157545.1
Coordinates 2039450..2039821 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag CS942_RS09545 Protein ID WP_004157544.1
Coordinates 2039818..2040039 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS942_RS09520 2035331..2035780 + 450 WP_004157563.1 DUF4385 domain-containing protein -
CS942_RS09525 2035865..2036500 - 636 WP_004157562.1 carbonic anhydrase -
CS942_RS09530 2036626..2038566 - 1941 WP_004157559.1 methyl-accepting chemotaxis protein -
CS942_RS09540 2039450..2039821 - 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CS942_RS09545 2039818..2040039 - 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CS942_RS09550 2040341..2041813 + 1473 WP_004157542.1 catalase -
CS942_RS09555 2041900..2042649 - 750 WP_099258145.1 5'-nucleotidase, lipoprotein e(P4) family -
CS942_RS09560 2042773..2043249 - 477 WP_004157540.1 GNAT family N-acetyltransferase -
CS942_RS09565 2043362..2043571 - 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2039450..2055220 15770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T294489 WP_004157545.1 NZ_NQJO01000001:c2039821-2039450 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

>T294489 NZ_NQJO01000001:c2039821-2039450 [Erwinia amylovora]
ATGATTTATTTTCTATCCAGTCAAGACATCATCGGCATTCATCAGCGTATGATCGTCGCTTACGGCGGTCTTGCCGGTTA
TGCCGATCCTGGTCGGATAGAAAGTATGGCAACACGGATTCTGAACCGCCACATCTACGAAGGTGAGGATGATATCTATA
TTCTGGCAGCTGCATATCTGCTGGCCATTGCGCGCGGGCATTGTTTCAATGATGCAAATAAGAGAACCGCATTTGCTTCA
ACTGCTTTATTCCTGCGCCGTAATGGCATTCTTCTTCGCTTTTCCCCAATCCATGAACAGCTGACTGTCTCAGCAGCACA
GGGGAGCCTGGATGTGTGGCACATTGCTGAAGCACTGAAACAGTCGACATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT294489 WP_004157544.1 NZ_NQJO01000001:c2040039-2039818 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp

>AT294489 NZ_NQJO01000001:c2040039-2039818 [Erwinia amylovora]
ATGCAAGCTATAAACTTTACTACCGCCCGTAACGAACTGGCATCAGTTCTTGATAGCGTTGCCAGCGGTGAGCCAGTTAT
GATCACCCGCAGATCGGCCAAATCCGTGGTTGTGGTTGATGCCGCGCAGTATGAAAAAATGCAAAAAATTCAGGCAGAAT
CGGACTTTGATTGGTTGTTTACAGAACATGGCCAGACGCTTGAAGCTCTTAAAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References