Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 252991..253580 | Replicon | chromosome |
Accession | NZ_CP076595 | ||
Organism | Erwinia amylovora isolate CP20130202 |
Toxin (Protein)
Gene name | doc | Uniprot ID | D4I2L7 |
Locus tag | KQH34_RS01150 | Protein ID | WP_004157545.1 |
Coordinates | 252991..253362 (-) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | D4I2L6 |
Locus tag | KQH34_RS01155 | Protein ID | WP_004157544.1 |
Coordinates | 253359..253580 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQH34_RS01135 (KQH34_01145) | 248872..249321 | + | 450 | WP_004157563.1 | DUF4385 domain-containing protein | - |
KQH34_RS01140 (KQH34_01150) | 249406..250041 | - | 636 | WP_004157562.1 | carbonic anhydrase | - |
KQH34_RS01145 (KQH34_01155) | 250167..252107 | - | 1941 | WP_004157559.1 | methyl-accepting chemotaxis protein | - |
KQH34_RS01150 (KQH34_01160) | 252991..253362 | - | 372 | WP_004157545.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
KQH34_RS01155 (KQH34_01165) | 253359..253580 | - | 222 | WP_004157544.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KQH34_RS01160 (KQH34_01170) | 254373..255845 | + | 1473 | WP_004157542.1 | catalase | - |
KQH34_RS01165 (KQH34_01175) | 255932..256681 | - | 750 | WP_004157541.1 | 5'-nucleotidase, lipoprotein e(P4) family | - |
KQH34_RS01170 (KQH34_01180) | 256805..257281 | - | 477 | WP_004157540.1 | GNAT family N-acetyltransferase | - |
KQH34_RS01175 (KQH34_01185) | 257394..257603 | - | 210 | WP_004157539.1 | glycine zipper 2TM domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 252991..269252 | 16261 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13667.70 Da Isoelectric Point: 7.4182
>T206013 WP_004157545.1 NZ_CP076595:c253362-252991 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST
Download Length: 372 bp
>T206013 NZ_CP102065:c2692662-2692321 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
TTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
TTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8173.24 Da Isoelectric Point: 4.9861
>AT206013 WP_004157544.1 NZ_CP076595:c253580-253359 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR
Download Length: 222 bp
>AT206013 NZ_CP102065:c2692892-2692662 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | D4I2L7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831A2K1 |