Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 1750402..1750991 | Replicon | chromosome |
Accession | NZ_CP076594 | ||
Organism | Erwinia amylovora isolate CP20086202 |
Toxin (Protein)
Gene name | doc | Uniprot ID | D4I2L7 |
Locus tag | KQH36_RS07775 | Protein ID | WP_004157545.1 |
Coordinates | 1750402..1750773 (-) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | D4I2L6 |
Locus tag | KQH36_RS07780 | Protein ID | WP_004157544.1 |
Coordinates | 1750770..1750991 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQH36_RS07760 (KQH36_07780) | 1746283..1746732 | + | 450 | WP_004157563.1 | DUF4385 domain-containing protein | - |
KQH36_RS07765 (KQH36_07785) | 1746817..1747452 | - | 636 | WP_004157562.1 | carbonic anhydrase | - |
KQH36_RS07770 (KQH36_07790) | 1747578..1749518 | - | 1941 | WP_004157559.1 | methyl-accepting chemotaxis protein | - |
KQH36_RS07775 (KQH36_07795) | 1750402..1750773 | - | 372 | WP_004157545.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
KQH36_RS07780 (KQH36_07800) | 1750770..1750991 | - | 222 | WP_004157544.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KQH36_RS07785 (KQH36_07805) | 1751784..1753256 | + | 1473 | WP_004157542.1 | catalase | - |
KQH36_RS07790 (KQH36_07810) | 1753343..1754092 | - | 750 | WP_004157541.1 | 5'-nucleotidase, lipoprotein e(P4) family | - |
KQH36_RS07795 (KQH36_07815) | 1754216..1754692 | - | 477 | WP_004157540.1 | GNAT family N-acetyltransferase | - |
KQH36_RS07800 (KQH36_07820) | 1754805..1755014 | - | 210 | WP_004157539.1 | glycine zipper 2TM domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1750402..1766663 | 16261 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13667.70 Da Isoelectric Point: 7.4182
>T206007 WP_004157545.1 NZ_CP076594:c1750773-1750402 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST
Download Length: 372 bp
>T206007 NZ_CP102061:c5065048-5064941 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8173.24 Da Isoelectric Point: 4.9861
>AT206007 WP_004157544.1 NZ_CP076594:c1750991-1750770 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR
Download Length: 222 bp
>AT206007 NZ_CP102061:5065096-5065162 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | D4I2L7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831A2K1 |