Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1929498..1930087 Replicon chromosome
Accession NZ_CP104025
Organism Erwinia amylovora strain Ea915

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag MTP51_RS08540 Protein ID WP_004157545.1
Coordinates 1929498..1929869 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag MTP51_RS08545 Protein ID WP_004157544.1
Coordinates 1929866..1930087 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP51_RS08525 (MTP51_08525) 1925379..1925828 + 450 WP_004157563.1 DUF4385 domain-containing protein -
MTP51_RS08530 (MTP51_08530) 1925913..1926548 - 636 WP_004157562.1 carbonic anhydrase -
MTP51_RS08535 (MTP51_08535) 1926674..1928614 - 1941 WP_004157559.1 methyl-accepting chemotaxis protein -
MTP51_RS08540 (MTP51_08540) 1929498..1929869 - 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MTP51_RS08545 (MTP51_08545) 1929866..1930087 - 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTP51_RS08550 (MTP51_08550) 1930880..1932352 + 1473 WP_004157542.1 catalase -
MTP51_RS08555 (MTP51_08555) 1932439..1933188 - 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
MTP51_RS08560 (MTP51_08560) 1933312..1933788 - 477 WP_004157540.1 GNAT family N-acetyltransferase -
MTP51_RS08565 (MTP51_08565) 1933901..1934110 - 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1929498..1945759 16261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T257037 WP_004157545.1 NZ_CP104025:c1929869-1929498 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT257037 WP_004157544.1 NZ_CP104025:c1930087-1929866 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References